Immunohistochemical Expression of Signal Transducer and Activator of Transcription (STAT6) in Classic Hodgkin Lymphoma (CHL) STAT6 in Classic Hodgkin Lymphoma

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Published: Aug 28, 2024
DOI: https://doi.org/10.61919/jhrr.v4i3.1404
Keywords:
STAT 6 Hodgkin lymphoma Carcinoma

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Tabish Hassan
Department of Histopathology, PNS Shifa, Karachi, Pakistan
Nadeem Zafar
Department of Histopathology, CMH Lahore, Pakistan
Nighat Jamal
Department of Histopathology, PEMH Rawalpindi, Pakistan
Akhtar Ali Bajwa
Department of Histopathology, PNS Shifa, Karachi, Pakistan
Rabia Ahmad
Department of Histopathology, PNS Shifa, Karachi, Pakistan
Rabeea Zubair
Department of Dermatology, Jinnah Hospital, Lahore, Pakistan

Abstract

Background: Hodgkin lymphoma (HL) is a significant malignancy, with Classic Hodgkin Lymphoma (CHL) and Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL) being its main subtypes. STAT6, a transcription factor in the IL-4/IL-13 pathway, may aid in distinguishing between these subtypes through immunohistochemical analysis.
Objective: To evaluate the diagnostic utility of STAT6 immunohistochemical expression in differentiating CHL from NLPHL.
Methods: A comparative cross-sectional study was conducted on 94 lymphoma cases, including 53 CHL and 41 NLPHL cases. Tissue samples were fixed, processed, and stained with STAT6 antibody. Nuclear and cytoplasmic STAT6 expression was assessed in neoplastic cells. Statistical analysis was performed using SPSS version 25, with Fisher’s exact test applied.
Results: Nuclear STAT6 expression was observed in 100% of CHL cases (53/53) and in 24.39% of NLPHL cases (10/41). Combined nuclear and cytoplasmic STAT6 expression was present in all CHL cases (53/53) but absent in NLPHL cases (0/41).
Conclusion: STAT6 nuclear expression serves as a reliable marker to distinguish CHL from NLPHL, with a 100% negative predictive value for NLPHL.

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How to Cite
Tabish Hassan, Nadeem Zafar, Nighat Jamal, Akhtar Ali Bajwa, Rabia Ahmad, & Rabeea Zubair. (2024). Immunohistochemical Expression of Signal Transducer and Activator of Transcription (STAT6) in Classic Hodgkin Lymphoma (CHL): STAT6 in Classic Hodgkin Lymphoma . Journal of Health and Rehabilitation Research, 4(3), 1–4. https://doi.org/10.61919/jhrr.v4i3.1404
Issue
Vol. 4 No. 3 (2024): Volume 4, Issue 3 - July to September 2024
Section
Articles
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This work is licensed under a Creative Commons Attribution 4.0 International License.

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