Medication Adherence And Its Associated Factors Among Patients With Type 2 Diabetes Mellitus In Pakistan
DOI:
https://doi.org/10.61919/jhrr.v6i6.2013Keywords:
Keywords: Type 2 diabetes mellitus; medication adherence; non-adherence; Pakistan; diabetes knowledge; treatment satisfaction; cross-sectional study.Abstract
Background: Medication adherence is essential for glycemic control and prevention of complications among patients with type 2 diabetes mellitus, yet non-adherence remains common in outpatient clinical settings. Objective: To assess medication adherence and identify factors associated with adherence among patients with type 2 diabetes mellitus attending Lahore General Hospital, Lahore, Pakistan. Methods: This hospital-based analytical cross-sectional study included 347 adult patients with type 2 diabetes mellitus receiving oral antidiabetic drugs, insulin, or both. Data were collected using a structured questionnaire covering demographic, socioeconomic, clinical, behavioral, and treatment-related characteristics. Medication adherence was assessed using a standardized adherence assessment tool. Associations were evaluated using bivariate analysis and binary logistic regression, with adjusted odds ratios reported for independent predictors. Results: Good or high adherence ranged from 28.4% to 55.6%, poor or low adherence from 34.7% to 48.5%, and non-adherence from 42.7% to 62.0%. Mean age ranged from 48.8 to 56.6 years, and diabetes duration ranged from 5.58 to 8.40 years. Age below 50 years, married status, and non-smoking status were associated with adherence, with adjusted odds ratios of 1.88, 4.118, and 12.98, respectively. Education level, socioeconomic status, multiple daily dosing, diabetes knowledge, and treatment satisfaction were also associated with adherence. Conclusion: Medication adherence among patients with type 2 diabetes mellitus was suboptimal and influenced by demographic, behavioral, socioeconomic, and treatment-related factors.
Downloads
References
Shakya P, Shrestha A, Karmacharya BM, Morisky DE, Kulseng BE. Factors associated with medication adherence among patients with type 2 diabetes mellitus: a hospital-based cross-sectional study in Nepal. Int J Environ Res Public Health. 2023;20(2):1537. doi:10.3390/ijerph20021537.
Hassan-Gillani A, Saeed A, Khanum F, Uz-Zaman MQ, Akbar J. Evaluation of factors associated with medication adherence and hypertension among diabetic patients in Pakistan. Rev Med Univ. 2020;22(1). doi:10.24875/rmu.19000130.
Ihsan N, Yasir S, Gilani H, Hussain N, Haq ZU, Ullah A, et al. Factors associated with poor compliance in type 2 diabetic patients presenting to Ayub Teaching Hospital. J Health Wellness Community Res. 2025. doi:10.61919/dwqhat32.
Huang YM, Shiyanbola O, Chan HY, Smith PD. Patient factors associated with diabetes medication adherence at different health literacy levels: a cross-sectional study at a family medicine clinic. Postgrad Med. 2020. doi:10.1080/00325481.2020.1749499.
Ishaq R, Haider S, Saleem F, Bashir S, Tareen A, Mengal MA, et al. Diabetes-related knowledge, medication adherence, and health-related quality of life: a correlation analysis. Altern Ther Health Med. 2020.
Majeed A, Rehman M, Hussain I, Imran I, Saleem MU, Saeed H, et al. The impact of treatment adherence on quality of life among type 2 diabetes mellitus patients: findings from a cross-sectional study. Patient Prefer Adherence. 2021. doi:10.2147/PPA.S295012.
Skriver LKL, Nielsen MW, Walther S, Nørlev J, Hangaard S. Factors associated with adherence or nonadherence to insulin therapy among adults with type 2 diabetes mellitus: a scoping review. J Diabetes Complications. 2023. doi:10.1016/j.jdiacomp.2023.108596.
Alsaidan A, Alotaibi SF, Thirunavukkarasu A, Alruwaili B, Alharbi R, Arnous MM, et al. Medication adherence and its associated factors among patients with type 2 diabetes mellitus attending primary health centers of Eastern Province, Saudi Arabia. Medicina. 2023. doi:10.3390/medicina59050989.
Studer C, Linder M, Pazzagli L. A global systematic overview of socioeconomic factors associated with antidiabetic medication adherence in individuals with type 2 diabetes. J Health Popul Nutr. 2023. doi:10.1186/s41043-023-00459-2.
Zairina E, Nugraheni G, Sulistyarini A, Mufarrihah, Setiawan CD, Kripalani S, et al. Factors related to barriers and medication adherence in patients with type 2 diabetes mellitus: a cross-sectional study. J Diabetes Metab Disord. 2022. doi:10.1007/s40200-021-00961-6.
Alshayban D, Naqvi A, Alhumaid O, Alqahtani AS, Islam MA, Ghori S, et al. Association of disease knowledge and medication adherence among out-patients with type 2 diabetes mellitus in Khobar, Saudi Arabia. Front Pharmacol. 2020. doi:10.3389/fphar.2020.00060.
Noreen N, Bashir F, Khan AW, Safi M, Lashari WA, Hering D. Determinants of adherence to antihypertension medications among patients at a tertiary care hospital in Islamabad, Pakistan, 2019. Prev Chronic Dis. 2023. doi:10.5888/pcd20.220231.
Bukhsh A, Goh BH, Zimbudzi E, Lo C, Zoungas S, Chan KG, et al. Type 2 diabetes patients’ perspectives, experiences, and barriers toward diabetes-related self-care: a qualitative study from Pakistan. Front Endocrinol. 2020;11. doi:10.3389/fendo.2020.534873.
Sahoo J, Mohanty S, Kundu A, Epari V. Medication adherence among patients of type II diabetes mellitus and its associated risk factors: a cross-sectional study in a tertiary care hospital of Eastern India. Cureus. 2022. doi:10.7759/cureus.33074.
Xie Z, Liu K, Or C, Chen J, Yan M, Wang H. An examination of the socio-demographic correlates of patient adherence to self-management behaviors and the mediating roles of health attitudes and self-efficacy among patients with coexisting type 2 diabetes and hypertension. BMC Public Health. 2020. doi:10.1186/s12889-020-09274-4.
Wibowo MINA, Yasin N, Kristina S, Prabandari Y. Exploring determinants of anti-diabetic medication adherence in several regions of Asia: a systematic review. Patient Prefer Adherence. 2022. doi:10.2147/PPA.S347079.
Mannan A, Hasan M, Akter F, Rana M, Chowdhury NA, Rawal LB, et al. Factors associated with low adherence to medication among patients with type 2 diabetes at different healthcare facilities in southern Bangladesh. Glob Health Action. 2021. doi:10.1080/16549716.2021.1872895.
Butt M, Ong SC, Rafiq A, Malik T, Sajjad A, Batool N, et al. An observational multi-center study on type 2 diabetes treatment prescribing pattern and patient adherence to treatment. Sci Rep. 2023. doi:10.1038/s41598-023-50517-2.
Mirahmadizadeh A, Khorshidsavar H, Seif M, Sharifi M. Adherence to medication, diet and physical activity and the associated factors amongst patients with type 2 diabetes. Diabetes Ther. 2020. doi:10.1007/s13300-019-00750-8.
Ekenberg M, Qvarnström M, Sundström A, Martinell M, Wettermark B. Socioeconomic factors associated with poor medication adherence in patients with type 2 diabetes. Eur J Clin Pharmacol. 2023. doi:10.1007/s00228-023-03571-8.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Qurba Kiran

This work is licensed under a Creative Commons Attribution 4.0 International License.
Public Licensing Terms
This work is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). Under this license:
- You are free to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material) for any purpose, including commercial use.
- Attribution must be given to the original author(s) and source in a manner that is reasonable and does not imply endorsement. If changes were made to the material, this must be indicated.
- No additional restrictions may be applied that conflict with the terms of this license.
For more details, visit: https://creativecommons.org/licenses/by/4.0/