Association Between Prolonged Operative Time and Postoperative Adverse Events in Patients Undergoing Spine Surgery in Pakistan
DOI:
https://doi.org/10.61919/jhrr.v6i9.2046Keywords:
Adverse events; operative duration; Pakistan; spine surgery; postoperative complications; SAVES-V2Abstract
Background: Longer operative duration has been associated with complications following spinal procedures, but locally reported evidence from Pakistan remains limited. Objective: To examine the association between operative duration of at least 3 hours and adverse events among patients undergoing spine surgery. Methods: This prospective observational cohort study included 60 patients undergoing spine surgery at Johar Child Poly Clinic, Lahore, Pakistan. Age, sex, Charlson Comorbidity Index (CCI), operative duration, and adverse events classified using the Spinal Adverse Events Severity System, version 2 (SAVES-V2), were recorded. Operative time was categorized as <3 hours or ≥3 hours. The primary outcome was occurrence of at least one intraoperative or postoperative adverse event. Group comparisons and crude logistic regression were used. Results: Mean age was 55.8 ± 10.6 years, and 42 participants (70.0%) were male. Operations lasted <3 hours in 26 patients and ≥3 hours in 34. At least one adverse event occurred in 21 patients (35.0%): 5/26 (19.2%) in the shorter-duration group versus 16/34 (47.1%) in the longer-duration group (Fisher's exact p = 0.031). The crude odds ratio (OR) was 3.73 (95% confidence interval [CI] 1.14–12.21). The reported crude associations were OR 3.21 (95% CI 1.01–10.24) for early postoperative events and OR 2.68 (95% CI 0.72–9.93) for late postoperative events. Conclusion: Operative duration of at least 3 hours was associated with a greater occurrence of perioperative adverse events in this cohort. The association may partly reflect procedural complexity and other unmeasured factors. Keywords: Adverse events; operative duration; Pakistan; spine surgery; postoperative complications; SAVES-V2.
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Cheng H, Clymer JW, Chen BP, Sadeghirad B, Ferko NC, Cameron CG, et al. Prolonged operative duration is associated with complications: a systematic review and meta-analysis. J Surg Res. 2018;229:134–144. doi:10.1016/j.jss.2018.03.022.
Kim BD, Hsu WK, De Oliveira GS Jr, Saha S, Kim JYS. Operative duration as an independent risk factor for postoperative complications in single-level lumbar fusion: an analysis of 4588 surgical cases. Spine (Phila Pa 1976). 2014;39(6):510–520. doi:10.1097/BRS.0000000000000163.
Hersey AE, Durand WM, Eltorai AEM, DePasse JM, Daniels AH. Longer operative time in elderly patients undergoing posterior lumbar fusion is independently associated with increased complication rate. Global Spine J. 2019;9(2):179–184. doi:10.1177/2192568218789117.
Ondeck NT, Bohl DD, McLynn RP, Cui JJ, Bovonratwet P, Singh K, et al. Longer operative time is associated with increased adverse events after anterior cervical diskectomy and fusion: 15-minute intervals matter. Orthopedics. 2018;41(4):e483–e488. doi:10.3928/01477447-20180424-02.
Monetta A, Griffoni C, Falzetti L, Evangelisti G, Noli LE, Tedesco G, et al. Prolonged operative time significantly impacts on the incidence of complications in spinal surgery. J Orthop Surg Res. 2024;19(1):567. doi:10.1186/s13018-024-05066-3.
Pull ter Gunne AF, Cohen DB. Incidence, prevalence, and analysis of risk factors for surgical site infection following adult spinal surgery. Spine (Phila Pa 1976). 2009;34(13):1422–1428. doi:10.1097/BRS.0b013e3181a03013.
Veeravagu A, Patil CG, Lad SP, Boakye M. Risk factors for postoperative spinal wound infections after spinal decompression and fusion surgeries. Spine (Phila Pa 1976). 2009;34(17):1869–1872. doi:10.1097/BRS.0b013e3181adc989.
Elgafy H, Bransford RJ, McGuire RA, Dettori JR, Fischer D. Blood loss in major spine surgery: are there effective measures to decrease massive hemorrhage in major spine fusion surgery? Spine (Phila Pa 1976). 2010;35(9 Suppl):S47–S56. doi:10.1097/BRS.0b013e3181d833f6.
Camino-Willhuber G, Cabrera JP, Carazzo C, Guiroy A, Gagliardi M, Terrasa S, et al. Reporting complications in spinal surgery—a systematic literature review. World Neurosurg. 2021;150:e765–e770. doi:10.1016/j.wneu.2021.03.143.
Rampersaud YR, Anderson PA, Dimar JR 2nd, Fisher CG. Spinal Adverse Events Severity System, version 2 (SAVES-V2): inter- and intraobserver reliability assessment. J Neurosurg Spine. 2016;25(2):256–263. doi:10.3171/2016.1.SPINE14808.
Falzetti L, Griffoni C, Carretta E, Pezzi A, Monetta A, Cavallari C, et al. Factors associated with increased length of stay and risk of complications in 336 patients submitted to spine surgery: the role of a validated capture system (SAVES v2) as a first-line tool to properly face the problem. Eur Spine J. 2024;33(3):1028–1043. doi:10.1007/s00586-023-08036-1.
Lange N, Stadtmüller T, Scheibel S, Reischer G, Wagner A, Meyer B, et al. Analysis of risk factors for perioperative complications in spine surgery. Sci Rep. 2022;12(1):14350. doi:10.1038/s41598-022-18417-z.
Whitmore RG, Stephen JH, Vernick C, Campbell PG, Yadla S, Ghobrial GM, et al. ASA grade and Charlson Comorbidity Index of spinal surgery patients: correlation with complications and societal costs. Spine J. 2014;14(1):31–38. doi:10.1016/j.spinee.2013.03.011.
Kothari P, Lee NJ, Lakomkin N, Leven DM, Shin JI, Guzman JZ, et al. Impact of resident involvement on morbidity in adult patients undergoing fusion for spinal deformity. Spine (Phila Pa 1976). 2016;41(16):1296–1302. doi:10.1097/BRS.0000000000001522.
Pugely AJ, Gao Y, Martin CT, Callagh JJ, Weinstein SL, Marsh JL. The effect of resident participation on short-term outcomes after orthopaedic surgery. Clin Orthop Relat Res. 2014;472(7):2290–2300. doi:10.1007/s11999-014-3567-0.
Althausen PL, Kauk JR, Shannon S, Lu M, O'Mara TJ, Bray TJ. Operating room efficiency: benefits of an orthopaedic traumatologist at a level II trauma center. J Orthop Trauma. 2014;28(5):e101–e106. doi:10.1097/BOT.0b013e3182a59d6b.
Moiz B, Taghlabi KM, Somawardana I, Nanda R, Bhenderu LS, Guerrero J, et al. Identification of an operative time threshold for substantially increased postoperative complications following thoracolumbar spine surgery: a nationwide retrospective cohort analysis. World Neurosurg. 2025. doi:10.1016/j.wneu.2025.123897.
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