Prevalence of Diabetes Mellitus II and Usefulness of HbA1c as a Diagnostic Criterion

Prevalence of T2DM and HbA1c Diagnostic Utility

Authors

  • Sadam Hussain Shaikh Immunology Laboratory, Center of Hematology and Bone Marrow Transplant, Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences, Gambat, Pakistan
  • Farhaz Ahmed Khuhro Institute of Microbiology, Faculty of Natural Science, Shah Abdul Latif University, Khairpur Mir’s 66020, Sindh, Pakistan
  • Javed Ali Zardari Center of Hematology and Bone Marrow Transplant, Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences, Gambat, Pakistan
  • Rooma Khuhro Institute of Microbiology, Faculty of Natural Science, Shah Abdul Latif University, Khairpur Mir’s 66020, Sindh, Pakistan
  • Syed Ahmed Saeed Zaidi Department of Pathology - Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences, Gambat, Pakistan
  • Javed Ali Solangi Immunology Laboratory, Center of Hematology and Bone Marrow Transplant, Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences, Gambat, Pakistan
  • Iftakhar Ahmed Center of Hematology and Bone Marrow Transplant, Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences, Gambat, Pakistan
  • Mohsin Raza Gambhir Institute of Microbiology, Faculty of Natural Science, Shah Abdul Latif University, Khairpur Mir’s 66020, Sindh, Pakistan.
  • Majid Ali Mailto Institute of Microbiology, Faculty of Natural Science, Shah Abdul Latif University, Khairpur Mir’s 66020, Sindh, Pakistan

DOI:

https://doi.org/10.61919/jhrr.v4i3.1136

Keywords:

Prevalence, Diabetes Mellitus, Glycated Hemoglobin, Lipid Profile

Abstract

Background: Background: Type 2 Diabetes Mellitus (T2DM) is a significant global health challenge, with rising prevalence and associated complications. Hemoglobin A1c (HbA1c) is increasingly used as a diagnostic tool for long-term glycemic control.
Objective: To assess the prevalence of T2DM and evaluate the efficacy of HbA1c as a diagnostic criterion, while exploring its correlation with lipid profiles.
Methods: This cross-sectional study included 1,054 participants aged 25 years and above at Gambat Institute of Medical Sciences. Data collection involved demographic information, BMI calculation, random blood glucose (RBS) testing, and HbA1c measurement using the Advia 1800 Siemens analyzer. Lipid profiles were assessed, and the correlation between HbA1c levels and lipid abnormalities was analyzed using Pearson’s correlation coefficient. Data analysis was conducted using SPSS version 25.
Results: T2DM prevalence was 9.1% using HbA1c, with higher prevalence in males (4.7%) than females (4.4%). Significant correlations were observed between HbA1c levels and total cholesterol (p=0.0001), triglycerides (p=0.0057), and LDL (p=0.0012).
Conclusion: HbA1c is an effective diagnostic tool for T2DM and correlates significantly with lipid abnormalities, emphasizing its role in comprehensive diabetes management.

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References

Hameed I, Masoodi SR, Mir SA, Nabi M, Ghazanfar K, Ganai BA. Type 2 Diabetes Mellitus: From A Metabolic Disorder To An Inflammatory Condition. World J Diabetes. 2015;6(4):598-612.

Kumar R, Saha P, Kumar Y, Sahana S, Dubey A, Prakash O. A Review On Diabetes Mellitus: Type 1 & Type 2. World J Pharm Pharm Sci. 2020;9(10):838-50.

Wondmkun YT. Obesity, Insulin Resistance, And Type 2 Diabetes: Associations And Therapeutic Implications. Diabetes Metab Syndr Obes. 2020;13:3611-6.

Liu HY, Cao SY, Hong T, Han J, Liu Z, Cao W. Insulin Is A Stronger Inducer Of Insulin Resistance Than Hyperglycemia In Mice With Type 1 Diabetes Mellitus (T1DM). J Biol Chem. 2009;284(40):27090-100.

Balakumar P, Maung-U K, Jagadeesh G. Prevalence And Prevention Of Cardiovascular Disease And Diabetes Mellitus. Pharmacol Res. 2016;113:600-9.

Bommer C, Sagalova V, Heesemann E, Manne-Goehler J, Atun R, Bärnighausen T, et al. Global Economic Burden Of Diabetes In Adults: Projections From 2015 To 2030. Diabetes Care. 2018;41(5):963-70.

Kharroubi AT, Darwish HM. Diabetes Mellitus: The Epidemic Of The Century. World J Diabetes. 2015;6(6):850-67.

Ahmad SI, editor. Diabetes: An Old Disease, A New Insight. Springer Science & Business Media; 2013.

Blaslov K, Naranđa FS, Kruljac I, Renar IP. Treatment Approach To Type 2 Diabetes: Past, Present And Future. World J Diabetes. 2018;9(12):209-19.

Porta M. Diabetes In Ancient Times: The Long And Winding Road To Insulin. In: Unveiling Diabetes-Historical Milestones In Diabetology. Karger Publishers; 2020. p. 1-13.

Adnan M, Aasim M. Prevalence Of Type 2 Diabetes Mellitus In Adult Population Of Pakistan: A Meta-Analysis Of Prospective Cross-Sectional Surveys. Ann Glob Health. 2020;86(1):7.

World Health Organization. Diabetes Country Profiles 2016. World Health Organization; 2016.

Kumari S, Kumar D, Mittal M. An Ensemble Approach For Classification And Prediction Of Diabetes Mellitus Using Soft Voting Classifier. Int J Cogn Comput Eng. 2021;2:40-6.

Maraschin JDF, Murussi N, Witter V, Silveiro SP. Diabetes Mellitus Classification. Arq Bras Cardiol. 2010;95:40-6.

American Diabetes Association. Diagnosis And Classification Of Diabetes Mellitus. Diabetes Care. 2014;37(Suppl 1).

Furdell EL. The Early History Of Diabetes From Classical Times To The Renaissance: Diagnoses And Descriptions. In: Fatal Thirst: Diabetes In Britain Until Insulin. Brill; 2009. p. 13-37.

Mohan V, Bhavadharini B, Mukhopadhyay S, Nallaperumal S, Tiwaskar M, Anjana RM, et al. Diabetes In Pre-Independence India: Rediscovering A Forgotten Era. J Assoc Physicians India. 2021;69:80-4.

Kesavadev J, Basanth A, Kalra S. Unproven Therapies For Diabetes. In: The Diabetes Textbook: Clinical Principles, Patient Management And Public Health Issues. Springer International Publishing; 2023. p. 1125-39.

Tripathi K, Saboo B. Sadikot's International Textbook Of Diabetes. Jaypee Brothers Medical Publishers; 2019.

Basit A, Fawwad A, Siddiqui SA, Baqa K. Current Management Strategies To Target The Increasing Incidence Of Diabetes Within Pakistan. Diabetes Metab Syndr Obes. 2018;11:85-96.

Baral P, Shrestha R, Shrestha RN, Banstola D, Prajapati R. A Study Of Height, Weight And Body Mass Index In Nepalese. J Gandaki Med Coll Nepal. 2021;14(2):88-92.

Mohajan D, Mohajan HK. Body Mass Index (BMI) Is A Popular Anthropometric Tool To Measure Obesity Among Adults. J Innov Med Res. 2023;2(4):25-33.

Kim J, Kim B, Kim MK, Baek KH, Song KH, Han K, et al. Weight Change In Patients With New-Onset Type 2 Diabetes Mellitus And Its Association With Remission: Comprehensive Real-World Data. Diabetes Obes Metab. 2024;26(2):567-75.

Yamada T, Kimura-Koyanagi M, Sakaguchi K, Ogawa W, Tamori Y. Obesity And Risk For Its Comorbidities Diabetes, Hypertension, And Dyslipidemia In Japanese Individuals Aged 65 Years. Sci Rep. 2023;13(1):2346.

Nathan DM, Turgeon H, Regan S. Relationship Between Glycated Haemoglobin Levels And Mean Glucose Levels Over Time. Diabetologia. 2007;50:2239-44.

Saleem T, Mohammad KH, Abdel-Fattah MM, Abbasi AH. Association Of Glycosylated Haemoglobin Level And Diabetes Mellitus Duration With The Severity Of Coronary Artery Disease. Diabetes Vasc Dis Res. 2008;5(3):184-9.

Xu X, Yang W, Deng Y, Liu L, Zhang X, Long C, et al. Association Of Socioeconomic Status With Glycated Haemoglobin Level And Risk Factors For Diabetic Retinopathy: A Cross-Sectional Study In Sichuan, Western China. BMJ Open. 2023;13(2).

El-Bab MF, Shawky N, Al-Sisi A, Akhtar M. Retinopathy And Risk Factors In Diabetic Patients From Al-Madinah Al-Munawarah In The Kingdom Of Saudi Arabia. Clin Ophthalmol. 2012;6:269-76.

Callaghan BC, Cheng HT, Stables CL, Smith AL, Feldman EL. Diabetic Neuropathy: Clinical Manifestations And Current Treatments. Lancet Neurol. 2012;11(6):521-34.

American Diabetes Association. 2. Classification And Diagnosis Of Diabetes: Standards Of Medical Care In Diabetes—2018. Diabetes Care. 2018;41(Suppl 1).

Karavanaki K, Rodolaki K, Soldatou A, Karanasios S, Kakleas K. Covid-19 Infection In Children And Adolescents And Its Association With Type 1 Diabetes Mellitus (T1D) Presentation And Management. Endocrine. 2023;80(2):237-52.

Mirabelli M, Tocci V, Donnici A, Giuliano S, Sarnelli P, Salatino A, et al. Maternal Preconception Body Mass Index Overtakes Age As A Risk Factor For Gestational Diabetes Mellitus. J Clin Med. 2023;12(8):2830.

Jobe M, Mactaggart I, Bell S, Kim MJ, Hydara A, Bascaran C, et al. Prevalence Of Hypertension, Diabetes, Obesity, Multimorbidity, And Related Risk Factors Among Adult Gambians: A Cross-Sectional Nationwide Study. Lancet Glob Health. 2024;12(1).

Ragu S. An Analytical Cross Sectional Study Of Vitamin D Levels In Newly Diagnosed Diabetic Patients When Compared With Non-Diabetics [Doctoral Dissertation]. Madras Medical College, Chennai; 2022.

Yahyavi SK, Snorgaard O, Knop FK, Schou M, Lee C, Selmer C, et al. Prediabetes Defined By First Measured HbA1c Predicts Higher Cardiovascular Risk Compared With HbA1c In The Diabetes Range: A Cohort Study Of Nationwide Registries. Diabetes Care. 2021;44(12):2767-74.

Sugimoto T, Sakurai T, Uchida K, Kuroda Y, Tokuda H, Omura T, et al. Impact Of Type 2 Diabetes And Glycated Hemoglobin Levels Within The Recommended Target Range On Mortality In Older Adults With Cognitive Impairment Receiving Care At A Memory Clinic: NCGG-STORIES. Diabetes Care. 2024;47(2).

Sherwani SI, Khan HA, Ekhzaimy A, Masood A, Sakharkar MK. Significance Of HbA1c Test In Diagnosis And Prognosis Of Diabetic Patients. Biomark Insights. 2016;11.

Abd El-Aal A, Abd El-Ghffar EA, Ghali AA, Zughbur MR, Sirdah MM. The Effect Of Vitamin C And/Or E Supplementations On Type 2 Diabetic Adult Males Under Metformin Treatment: A Single-Blinded Randomized Controlled Clinical Trial. Diabetes Metab Syndr Clin Res Rev. 2018;12(4):483-9.

Danese E, Montagnana M, Nouvenne A, Lippi G. Advantages And Pitfalls Of Fructosamine And Glycated Albumin In The Diagnosis And Treatment Of Diabetes. J Diabetes Sci Technol. 2015;9(2):169-76.

Al-Biltagi M, Tolba OARE, Rowisha MA, Mahfouz AES, Elewa MA. Speckle Tracking And Myocardial Tissue Imaging In Infant Of Diabetic Mother With Gestational And Pregestational Diabetes. Pediatr Cardiol. 2015;36(3):445-53.

Forbes A, Murrells T, Mulnier H, Sinclair AJ. Mean HbA1c, HbA1c Variability, And Mortality In People With Diabetes Aged 70 Years And Older: A Retrospective Cohort Study. Lancet Diabetes Endocrinol. 2018;6(6):476-85.

Chauhan S. A Mobile Platform For Non-Invasive Diabetes Screening [Doctoral Dissertation]. Massachusetts Institute Of Technology; 2019.

Lucha-López MO, Vidal-Peracho C, Hidalgo-García C, Rodríguez-Sanz J, Tricás-Vidal H, Hernández-Secorún M, et al. Anthropometric Measurements, Metabolic Profile And Physical Fitness In A Sample Of Spanish Women With Type 2 Diabetes. Int J Environ Res Public Health. 2021;18(22):11955.

Roan JN, Lin WH, Tsai MT, Kuo TH, Lin TW, Chen DY, et al. Rosuvastatin Failed To Improve Arteriovenous Fistula Patency For Hemodialysis In Diabetic Patients–A Randomized Clinical Trial. Acta Cardiol Sin. 2021;37(1):18.

Nowak C, Ärnlöv J. Kidney Disease Biomarkers Improve Heart Failure Risk Prediction In The General Population. Circ Heart Fail. 2020;13(8).

Constance A, Frederick R. Has Glycaemic Control In Diabetes Mellitus Improved Since The Introduction Of Point-Of-Care Glycated Haemoglobin A1c?. Wits J Clin Med. 2020;2(2):157-62.

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Published

2024-08-23

How to Cite

Sadam Hussain Shaikh, Farhaz Ahmed Khuhro, Javed Ali Zardari, Rooma Khuhro, Syed Ahmed Saeed Zaidi, Javed Ali Solangi, Iftakhar Ahmed, Mohsin Raza Gambhir, & Majid Ali Mailto. (2024). Prevalence of Diabetes Mellitus II and Usefulness of HbA1c as a Diagnostic Criterion: Prevalence of T2DM and HbA1c Diagnostic Utility. Journal of Health and Rehabilitation Research, 4(3), 1–6. https://doi.org/10.61919/jhrr.v4i3.1136