Comparative Study of Sonographic Evaluation of Common Carotid Intima-Media Thickness Among Obese and Non-Obese Type II Diabetic Patients Carotid IMT in Obese vs. Non-Obese Diabetic Patients
Main Article Content
Abstract
Background: Intima-media thickness (IMT) is a marker of cardiovascular risk and is influenced by factors such as obesity and type II diabetes. Assessing IMT in diabetic patients provides insights into their cardiovascular health.
Objective: To compare the common carotid intima-media thickness between obese and non-obese type II diabetic patients.
Methods: This case-control study was conducted at the Department of Radiology, Services Hospital, Lahore, over three months. A total of 86 type II diabetic patients aged 30-75 years were included, with 43 obese and 43 non-obese participants. Carotid IMT was measured using gray-scale B-mode ultrasound. Participants were positioned supine with the neck extended, and the common carotid arteries were scanned. Data analysis was performed using SPSS version 25.0, with independent t-tests to compare IMT between groups and Pearson correlation to assess the association with diabetes duration.
Results: The mean IMT for obese patients was 0.842 mm (SD = 0.152) for the left CCA and 0.858 mm (SD = 0.119) for the right CCA. In non-obese patients, mean IMT was 0.592 mm (SD = 0.134) for the left CCA and 0.616 mm (SD = 0.127) for the right CCA. Significant differences were observed between groups (p < 0.001).
Conclusion: Obese type II diabetic patients have significantly higher carotid IMT compared to non-obese patients, emphasizing the impact of obesity on cardiovascular risk.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
American Diabetes Association. Classification and diagnosis of diabetes: standards of medical care in diabetes—2019. Diabetes Care. 2019;42(Supplement_1).
Bulut A, Avci B. Carotid Intima-Media Thickness Values Are Significantly Higher in Patients with Prediabetes Compared to Normal Glucose Metabolism. Medicine. 2019;98(44).
Casella IB, Presti C, Porta RMP, Sabbag CRD, Bosch MA, Yamazaki Y. A Practical Protocol to Measure Common Carotid Artery Intima-Media Thickness. Clinics. 2008;63:515-520.
Corti R, Fuster V, Badimon JJ. Pathogenetic Concepts of Acute Coronary Syndromes. J Am Coll Cardiol. 2003;41(4S).
Homma S, Hirose N, Ishida H, Ishii T, Araki G. Carotid Plaque and Intima-Media Thickness Assessed by B-Mode Ultrasonography in Subjects Ranging from Young Adults to Centenarians. Stroke. 2001;32(4):830-835.
Hong SB, Lee JJ, Kim SH, Suh YJ, Han JY, Kim YS, et al. The Effects of Adiponectin and Inflammatory Cytokines on Diabetic Vascular Complications in Obese and Non-Obese Patients with Type 2 Diabetes Mellitus. Diabetes Res Clin Pract. 2016;111:58-65.
Kronenberg HM, Melmed S, Polonsky KS, Wilson JD, Foster DW. Williams Textbook of Endocrinology. 2002.
Liu KH, Chan YL, Chan JCN, Chan WB. Association of Carotid Intima-Media Thickness with Mesenteric, Preperitoneal and Subcutaneous Fat Thickness. Atherosclerosis. 2005;179(2):299-304.
Meijers A, Seller Oria C, Free J, Langendijk JA, Knopf AC, Both S. First Report on an In Vivo Range Probing Quality Control Procedure for Scanned Proton Beam Therapy in Head and Neck Cancer Patients. Med Phys. 2021;48(3):1372-1380.
Meo SA, Zia I, Bukhari IA, Arain SA. Type 2 Diabetes Mellitus in Pakistan: Current Prevalence and Future Forecast. J Pak Med Assoc. 2016;66(12):1637-1642.
Mendonça JA, de Andrade BB, de Aquino JLB, Leandro-Merhi VA, Damian GB. Spectral Doppler and Automated Software-Guided Ultrasound Assessment of Bilateral Common Carotid Intima-Media Thickness in Spondyloarthritis: Is There a Correlation with Clinical Findings?. Drugs Context. 2018;7.
Tranquart F, Bergès O, Koskas P, Arsene S, Rossazza C, Pisella PJ, et al. Color Doppler Imaging of Orbital Vessels: Personal Experience and Literature Review. J Clin Ultrasound. 2003;31(5):258-273.
Wang S, Sun Q, Zhai L, Bai Y, Wei W, Jia L. The Prevalence of Depression and Anxiety Symptoms among Overweight/Obese and Non-Overweight/Non-Obese Children/Adolescents in China: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2019;16(3):340.
Poredos P. Intima-Media Thickness: Indicator of Cardiovascular Risk and Measure of the Extent of Atherosclerosis. Vasc Med. 2004;9(1):46-54.
Nadeem B, Bacha R, Gilani SA. Correlation of Subcutaneous Fat Measured on Ultrasound with Body Mass Index. J Med Ultrasound. 2018;26(4):205.
Hollander M, Bots ML, Del Sol AI, Koudstaal PJ, Witteman JC, Grobbee DE, et al. Carotid Plaques Increase the Risk of Stroke and Subtypes of Cerebral Infarction in Asymptomatic Elderly: The Rotterdam Study. Circulation. 2002;105(24):2872-2877.
Mohan V, Ravikumar R, Shanthi Rani S, Deepa R. Intimal Medial Thickness of the Carotid Artery in South Indian Diabetic and Non-Diabetic Subjects: The Chennai Urban Population Study (CUPS). Diabetologia. 2000;43:494-499.
Alizadeh A, Roudbari A, Heidarzadeh A, Jandaghi AB, Jamali MB. Ultrasonic Measurement of Common Carotid Intima-Media Thickness in Type 2 Diabetic and Non-Diabetic Patients. Iran J Radiol. 2012;9(2):79.
Elshorbagy HH, Fouda ER, Kamal NM, Bassiouny MM, Fathi WM. Evaluation of Epicardial Fat and Carotid Intima-Media Thickness in Obese Children. Iran J Pediatr. 2016;26(1).
Reinehr T, Wunsch R. Intima Media Thickness – Related Risk Factors in Childhood Obesity. Int J Pediatr Obes. 2011;6(1):46-52.
Garcia MJ, McNamara PM, Gordon T, Kannell WB. Morbidity and Mortality in Diabetics in the Framingham Population: Sixteen-Year Follow-Up Study. Diabetes. 2008;23(2):105-111.