Comparing Efficacy of Intravenous Versus Oral Iron Therapy in Iron Deficiency Anaemia: A Comparative Prospective Study IV vs Oral Iron Therapy in IDA
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Abstract
Background: Iron deficiency anaemia (IDA) is a prevalent global health problem associated with significant morbidity. Traditional oral iron therapy is often limited by gastrointestinal side effects and poor absorption. Intravenous (IV) iron may provide a faster and more effective alternative.
Objective: This study aims to compare the efficacy and safety of IV iron replacement with oral iron supplementation in patients with IDA.
Methods: A randomized, single-centre, prospective interventional study was conducted with 200 adult patients diagnosed with IDA. Patients were randomized into two groups: IV iron (ferric carboxymaltose) or oral iron (ferrous sulphate) for 12 weeks. Haemoglobin and ferritin levels were measured at baseline, 6 weeks, and 12 weeks. Treatment adherence and adverse effects were also monitored.
Results: The IV iron group showed a significantly higher mean increase in haemoglobin (4.3 ± 1.1 g/dL) compared to the oral iron group (2.7 ± 1.4 g/dL, p < 0.001). Ferritin levels improved by 69.6 ± 14.2 ng/mL in the IV group versus 29.5 ± 10.8 ng/mL in the oral group (p < 0.001).
Conclusion: IV iron is more effective and better tolerated than oral iron for IDA management, particularly in scenarios requiring rapid correction.
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