Association Between Iron Deficiency Anemia and Chronic Daily Headache
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Abstract
Background: Chronic daily headache (CDH) and iron deficiency anemia (IDA) are prevalent health issues with significant impact on individuals' quality of life. Understanding the relationship between these conditions is essential for developing effective treatment strategies.
Objective: This study aims to investigate the association between iron deficiency anemia and chronic daily headache.
Methods: A case-control study was conducted at Pak Emirates Military Hospital, Rawalpindi, Pakistan, from February to July 2023. The study included 140 patients diagnosed with CDH and 140 age- and sex-matched controls without a history of CDH. Demographic data (age, gender, location, education, marital status) were collected along with clinical characteristics (headache frequency, intensity, duration) and hematological parameters (hemoglobin level, serum ferritin level, red blood cell count, mean corpuscular volume, mean corpuscular hemoglobin, platelet count, white blood cell count, hematocrit level, mean corpuscular hemoglobin concentration). Statistical analysis was performed using chi-square tests and ANOVA.
Results: There were no significant differences in demographic characteristics between the CDH and control groups. CDH patients exhibited higher headache frequency (57.14% experienced headaches 10-15 times per month), intensity (64.43% reported NRS score of 5-8), and duration (87.15% reported headache duration of over 4 hours) compared to controls. Hematological analysis revealed significantly lower mean hemoglobin (9.85±2.13 g/dL) and serum ferritin levels (30.72±7.65 ng/mL) in CDH patients compared to controls (13.1±2.70 g/dL and 65.09±12.82 ng/mL, respectively). A significant association between IDA and CDH was established (p<0.05).
Conclusion: The study demonstrates a significant association between iron deficiency anemia and chronic daily headache, highlighting the potential role of iron deficiency in the development of CDH.
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References
Singh RK, Kaushik RM, Goel D, Kaushik R. Association between iron deficiency anemia and chronic daily headache: A case-control study. Cephalalgia. 2023 Feb;43(2):3331024221143540. DOI: 10.1177/03331024221143540
Abbaspour N, Hurrell R, Kelishadi R. Review on iron and its importance for human health. J Res Med Sci. 2014 Feb;19(2):164-74.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999603/
Ahmed F, Parthasarathy R, Khalil M. Chronic daily headaches. Ann Indian Acad Neurol. 2012 Aug;15(Suppl 1):S40-50. doi: 10.4103/0972-2327.100002
Miller JL. Iron deficiency anemia: a common and curable disease. Cold Spring Harb Perspect Med. 2013 Jul 1;3(7):a011866. doi: 10.1101/cshperspect.a011866
Kumar SB, Arnipalli SR, Mehta P, Carrau S, Ziouzenkova O. Iron Deficiency Anemia: Efficacy and Limitations of Nutritional and Comprehensive Mitigation Strategies. Nutrients. 2022 Jul 20;14(14):2976. DOI: 10.3390/nu14142976
Cappellini MD, Musallam KM, Taher AT. Iron deficiency anaemia revisited. J Intern Med. 2020 Feb;287(2):153-170. DOI: 10.1111/joim.13004
Murphy C, Hameed S. Chronic Headaches. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022. Bookshelf ID: NBK559083
Cocores AN, Monteith TS. Headache as a Neurologic Manifestation of Systemic Disease. Curr Treat Options Neurol. 2022;24(1):17-40. DOI: 10.1007/s11940-022-00704-9
Jimenez K, Kulnigg-Dabsch S, Gasche C. Management of Iron Deficiency Anemia. Gastroenterol Hepatol (N Y). 2015 Apr;11(4):241-50. PMCID: PMC4836595; PMID: 27099596.
Domellöf M, Hernell O, Dewey KG, Lönnerdal BO, Roberta J. Cohen RJ. The Diagnostic Criteria for Iron Deficiency in Infants Should Be Reevaluated. J Nutr. 2002;132(12):3680-3686. DOI: 10.1093/jn/132.12.3680
Choi CW, Cho WR, Park KH, Choi IK, Seo JH, Kim BS, Shin SW, Kim YH, Kim JS, Lee J. The cutoff value of serum ferritin for the diagnosis of iron deficiency in community-residing older persons. Ann Hematol. 2005 Jun;84(6):358-61. DOI: 10.1007/s00277-005-1033-5
Krebs EE, Carey TS, Weinberger M. Accuracy of the pain numeric rating scale as a screening test in primary care. J Gen Intern Med. 2007 Oct;22(10):1453-8. DOI: 10.1007/s11606-007-0321-2
Aamodt AH, Borch-Iohnsen B, Hagen K, et al. Headache prevalence related to hemoglobin and ferritin. The HUNT Study. Cephalalgia. 2004;24:758–762. DOI: 10.1111/j.1468-2982.2004.00756.x
Gür-Özmen S, Karahan-Özcan R. Iron deficiency anemia is associated with menstrual migraine: A case-control study. Pain Med. 2016;17:596–605. DOI: 10.1093/pm/pnv029
Sarper N, Zengin E, Cakı Kılıç S, Tugay M, Aydoğan A, Kayabey O. Severe iron deficiency anemia due to late presentation of congenital diaphragmatic hernia in a toddler. Turk J Haematol. 2012 Dec;29(4):430-1. doi: 10.5505/tjh.2012.92609
Tayyebi A, Poursadeghfard M, Nazeri M, Pousadeghfard T. Is There Any Correlation between Migraine Attacks and Iron Deficiency Anemia? A Case-Control Study. Int J Hematol Oncol Stem Cell Res. 2019 Jul 1;13(3):164-171. PMCID: PMC6801325
Welch KM, Nagesh V, Aurora SK, et al. Periaqueductal gray matter dysfunction in migraine: cause or the burden of illness? Headache. 2001;41(7):629–37. DOI: 10.1046/j.1526-4610.2001.041007629.x
Meng SH, Bo ZH, Xin L, Xue WM, Xin KL, Ming FJ, Xia L, Ting LX, Shuang ZY. Association Between Dietary Iron Intake and Serum Ferritin and Severe Headache or Migraine. Front Nutr. 2021;8:685564. DOI: 10.3389/fnut.2021.685564
Rashid S, Nawaz HK, Athar HM, Fakhar A,Hakeem F, Manzoor N. Frequency of Iron Deficiency Anemia in Young Females with Migraine. Pak Armed Forces Med J. 2022;72(Suppl-2): S371-374. DOI: https://doi.org/10.51253/pafmj.v72iSUPPL-2.2977
Herekar AD, Herekar AA, Ahmad A,Uqaili UL, Ahmed B, Effendi J, et al. The burden of headache disorders in Pakistan: methodology of a population-based nationwide study, and questionnaire validation. J Headache Pain. 2013;14(1):73. DOI: 10.1186/1129-2377-14-73