Association of Serum Uric Acid with Renal Function Indicators in Patients with Chronic Kidney Disease: A Cross-Sectional Study
DOI:
https://doi.org/10.61919/jhrr.v5i12.1946Keywords:
Chronic kidney disease, serum uric acid, creatinine, hyperuricemia, renal dysfunction, biomarkers, cross-sectional study.Abstract
Background: Chronic kidney disease is a progressive disorder characterized by declining renal function and metabolic disturbances. Hyperuricemia frequently occurs in patients with impaired kidney function and may reflect or contribute to renal dysfunction. Understanding the relationship between serum uric acid and traditional renal biomarkers may provide additional insights into metabolic changes associated with chronic kidney disease. Objective: To evaluate the association between serum uric acid and serum creatinine levels among patients with chronic kidney disease. Methods: A cross-sectional survey was conducted among 90 patients diagnosed with chronic kidney disease. Serum uric acid and serum creatinine levels were obtained from routine biochemical laboratory measurements. Descriptive statistics were calculated for biochemical parameters, and Pearson’s correlation analysis was used to assess the association between serum uric acid and creatinine levels. Statistical analysis was performed using SPSS with a significance threshold of p < 0.05. Results: The mean serum uric acid level was 6.35 ± 1.42 mg/dL, while the mean serum creatinine concentration was 2.58 ± 1.36 mg/dL. Male patients constituted 57.8% of the study population. Stage 3 chronic kidney disease was the most prevalent stage (32.2%). Pearson correlation analysis demonstrated a statistically significant positive correlation between serum uric acid and serum creatinine levels (r = 0.214, p = 0.043). Conclusion: Serum uric acid levels showed a significant positive association with serum creatinine among patients with chronic kidney disease. These findings suggest that elevated uric acid may reflect metabolic alterations associated with declining renal function and may serve as a complementary biomarker in the clinical evaluation of CKD patients.
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