Frequency of Need for Evacuation and Curettage Following Medical Termination by Misoprostol for Missed Miscarriage
DOI:
https://doi.org/10.61919/jhrr.v4i2.1113Keywords:
Missed miscarriage, misoprostol, surgical intervention, dilation and curettage, medical managementAbstract
Background: Missed miscarriage, characterized by the intrauterine death of an embryo or fetus without immediate expulsion, affects approximately 15% of clinically diagnosed pregnancies. While traditional management involves surgical evacuation, medical management using misoprostol has gained popularity as a less invasive alternative.
Objective: To evaluate the frequency of surgical intervention following medical management with misoprostol for missed miscarriage.
Materials and Methods: This descriptive study was conducted at Hayatabad Medical Complex, Peshawar, from January 9, 2021, to June 9, 2021. A total of 179 women aged 18 to 45 years with missed miscarriage were included. Patients were administered misoprostol and monitored for the need for subsequent surgical intervention. Data were collected and analyzed using SPSS version 23, with results presented in tables and graphs.
Results: Out of 179 participants, 60 (33.5%) required evacuation and curettage (D&C), while 119 (66.5%) did not. Ultrasound findings were the primary reason for D&C in 38 (63.3%) cases, with persistent bleeding accounting for the remaining 22 (36.7%). The mean endometrial thickness on ultrasound was 11.08 mm. The mean hospital stay was 48 hours. By the sixth week, 86.5% of women had resumed normal menstrual cycles.
Conclusion: Evacuation and curettage were required in 33.5% of patients following medical management with misoprostol for missed miscarriage, indicating that misoprostol effectively manages missed miscarriages in most cases, reducing the need for surgical intervention. Future studies with larger sample sizes and multicenter trials are recommended to confirm these findings and improve management protocols.
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References
Nybo Andersen AM, Wohlfahrt J, Christens P, Olsen J, Melbye M. Maternal Age and Fetal Loss: Population Based Register Linkage Study. BMJ. 2000;320(7251):1708-1712.
Bagratee JS, Khullar V, Regan L, Moodley J, Kagoro H. A Randomized Controlled Trial Comparing Medical and Expectant Management of First Trimester Miscarriage. Hum Reprod. 2004;19(2):266-271.
Hoveyda F, MacKenzie IZ. A Randomized Trial Comparing Medical and Surgical Treatment for Early Pregnancy Failure. BJOG. 2001;108(2):192-196.
Davis AR, Hendlish SK. Expectant Management for Early Pregnancy Failure: Effective, Safe, and Patient-Centered. Obstet Gynecol. 2004;104(4):845-846.
Weeks A. Misoprostol in Obstetrics and Gynaecology. BJOG. 2007;114(3):416-425.
Chung TK, Cheung LP, Leung TY, Haines CJ, Chang AM. Misoprostol in the Management of Spontaneous Abortion. BJOG. 1999;106(3):316-319.
Royal College of Obstetricians and Gynaecologists. The Management of Early Pregnancy Loss. Green-top Guideline No. 25. 2011. Available from: https://www.rcog.org.uk/en/guidelines-research-services/guidelines/gtg25/.
Trinder J, Brocklehurst P, Porter R, Read M, Vyas S, Smith L. Management of Miscarriage: Expectant, Medical, or Surgical? Results of Randomized Controlled Trial (Miscarriage Treatment [MIST] Trial). BMJ. 2006;332(7552):1235-1240.
Tang OS, Lau WN, Ng EH, Lee SW, Ho PC, Cheng L. A Prospective Randomized Study to Compare the Use of Mifepristone with Misoprostol and Misoprostol Alone in the Management of Missed Miscarriage. Hum Reprod. 2003;18(11):2315-2318.
Zhang J, Gilles JM, Barnhart K, Creinin MD, Westhoff C, Frederick MM. A Comparison of Medical Management with Misoprostol and Surgical Management for Early Pregnancy Failure. N Engl J Med. 2005;353(8):761-769.
Neilson JP, Gyte GM, Hickey M, Vazquez JC, Dou L. Medical Treatments for Incomplete Miscarriage. Cochrane Database Syst Rev. 2010;(1).
Wood SL, Brain PH. Medical Management of Missed Abortion: A Randomized Clinical Trial. Obstet Gynecol. 2002;99(4):563-566.
Graziosi GC, Mol BW, Ankum WM, Bruinse HW, Brolmann HA. Management of Early Pregnancy Loss. Int J Gynaecol Obstet. 2004;86(3):337-346.
Chu JJ, Devall AJ, Beeson LE, Hardy P, Cheed V, Coomarasamy A, Gallos ID. Quantifying the Risks of Using Misoprostol in the Treatment of Early Pregnancy Loss. BMJ Open. 2020;10(7).
Blanchard K, Clark S, Winikoff B, Gaines G, Kabani G, Shannon C. Misoprostol for Women's Health: A Review. Obstet Gynecol. 2002;99(2):316-332.
Ngoc NT, Blum J, Raghavan S, Nga NT, Dabash R, Diop A, Winikoff B. Comparing Two Early Medical Abortion Regimens: Mifepristone + Misoprostol vs. Misoprostol Alone. Contraception. 2011;83(5):410-417.
Shannon C, Brothers LP, Philip NM, Winikoff B, Blumenthal PD. Infection After Medical Abortion: A Review of the Literature. Contraception. 2004;70(3):183-190.
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