Comparative Study of Carotid Artery Disease in Hypertensive Versus Non-Hypertensive Patients Using Color Doppler Flow Imaging Gestational Carotid Disease in Hypertensive Patients

Main Article Content

Areeba Mahmood
Syed Muhammad Yousaf Farooq
Ume Kalsoom Attique
Hamna Areej
Haq Nawaz Khan
Muhammad Usama Tahir

Abstract

Background: Carotid artery disease is common in patients with hypertension, leading to thickened intima-media layers and narrowed arteries, increasing the risk of stroke and myocardial infarction.


Objective: This study compared Color Doppler findings in hypertensive and non-hypertensive patients, focusing on intima-media thickness (IMT) and Doppler indices.


Methods: A cross-sectional study was conducted on 120 patients at the University of Lahore, including 72 hypertensive and 48 non-hypertensive individuals. Doppler ultrasonography was performed using a Toshiba XARIO XG machine with a 5-7.5 MHz linear probe. Data on age, hypertension, diabetes status, gender, and IMT were collected. Doppler indices including Resistive Index (RI), Pulsatility Index (PI), End Diastolic Velocity (EDV), and Peak Systolic Velocity (PSV) were analyzed using SPSS version 25.0. An independent t-test compared Doppler indices between groups, with p < 0.05 considered significant.


Results: IMT was significantly higher in hypertensive patients (0.63 ± 0.16 mm right, 0.62 ± 0.14 mm left) compared to non-hypertensive patients (0.56 ± 0.14 mm right, 0.57 ± 0.14 mm left) with p-values of 0.013 and 0.048, respectively. No significant differences were found in other Doppler indices.


Conclusion: Hypertension is linked to increased carotid IMT, indicating a higher risk for plaque formation. Doppler ultrasound can help in early detection and prevention of cardiovascular diseases.

Article Details

How to Cite
Mahmood, A., Syed Muhammad Yousaf Farooq, Ume Kalsoom Attique, Hamna Areej, Haq Nawaz Khan, & Muhammad Usama Tahir. (2024). Comparative Study of Carotid Artery Disease in Hypertensive Versus Non-Hypertensive Patients Using Color Doppler Flow Imaging: Gestational Carotid Disease in Hypertensive Patients. Journal of Health and Rehabilitation Research, 4(3), 1–6. https://doi.org/10.61919/jhrr.v4i3.1254
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Articles
Author Biographies

Syed Muhammad Yousaf Farooq, University Institute of Radiological Sciences and Medical Imaging Technology, Faculty of Allied Health Sciences, University of Lahore, Pakistan

Assistant professor,University Institute of Radiological Sciences and Medical Imaging Technology, Faculty of Allied Health Sciences, University of Lahore, Pakistan.

Ume Kalsoom Attique, University Institute of Radiological Sciences and Medical Imaging Technology, Faculty of Allied Health Sciences, University of Lahore, Pakistan

Student, University Institute of Radiological Sciences and Medical Imaging Technology, Faculty of Allied Health Sciences, University of Lahore, Pakistan.

Hamna Areej, University Institute of Radiological Sciences and Medical Imaging Technology, Faculty of Allied Health Sciences, University of Lahore, Pakistan

Student, University Institute of Radiological Sciences and Medical Imaging Technology, Faculty of Allied Health Sciences, University of Lahore, Pakistan.

Haq Nawaz Khan, University Institute of Radiological Sciences and Medical Imaging Technology, Faculty of Allied Health Sciences, University of Lahore, Pakistan

Student, University Institute of Radiological Sciences and Medical Imaging Technology, Faculty of Allied Health Sciences, University of Lahore, Pakistan.

Muhammad Usama Tahir, University Institute of Radiological Sciences and Medical Imaging Technology, Faculty of Allied Health Sciences, University of Lahore, Pakistan

Student, University Institute of Radiological Sciences and Medical Imaging Technology, Faculty of Allied Health Sciences, University of Lahore, Pakistan.

References

Porcu M, Mannelli L, Melis M, Suri JS, Gerosa C, Cerrone G, et al. Carotid Plaque Imaging Profiling in Subjects with Risk Factors (Diabetes and Hypertension). Cardiovascular Diagnosis and Therapy. 2020;10(4):1005-13.

Salonen R, Salonen JT. Carotid Atherosclerosis in Relation to Systolic and Diastolic Blood Pressure: Kuopio Ischaemic Heart Disease Risk Factor Study. Annals of Medicine. 1991;23(1):23-7.

Harrison MJ, Wilson LA. Effect of Blood Pressure on Prevalence of Carotid Atheroma. Stroke. 1983;14(4):550-1.

Sutton-Tyrrell K, Alcorn HG, Wolfson SK Jr, Kelsey SF, Kuller LH. Predictors of Carotid Stenosis in Older Adults with and without Isolated Systolic Hypertension. Stroke. 1993;24(3):355-61.

Umeh EO, Agunloye AM, Adekanmi AJ, Adeyinka AO. Ultrasound Evaluation of Intima-Media Thickness of Carotid Arteries in Adults with Primary Hypertension at Ibadan, Nigeria. West African Journal of Medicine. 2013;32(1):62-7.

Sharma P, Lohani B, Chataut SP. Ultrasonographic Evaluation of Carotid Intima-Media Thickness in Hypertensive and Normotensive Individuals. Nepal Medical College Journal. 2009;11(2):133-5.

Freitas PD, Piccinato CE, Martins WD, Mauad Filho F. Carotid Atherosclerosis Evaluated by Doppler Ultrasound: Association with Risk Factors and Systemic Arterial Disease. Jornal Vascular Brasileiro. 2008;7:298-307.

Howard G, Sharrett AR, Heiss G, Evans GW, Chambless LE, Riley WA, et al. Carotid Artery Intimal-Medial Thickness Distribution in General Populations as Evaluated by B-mode Ultrasound. Stroke. 1993;24(9):1297-304.

Intercollegiate Stroke Working Party. National Clinical Guideline for Stroke. 5th ed. London: Royal College of Physicians; 2016.

Sacco RL. Extracranial Carotid Stenosis. New England Journal of Medicine. 2001;345(15):1113-8.

Melidonis A, Kyriazis IA, Georgopali A, Vlassopoulos A, Protopapa V, Terzi K, et al. Prognostic Value of the Carotid Artery Intima-Media Thickness for the Presence and Severity of Coronary Artery Disease in Type 2 Diabetic Patients. Diabetes Care. 2003;26:3189-90.

Salonen JT, Salonen R. Ultrasonographically Assessed Carotid Morphology and the Risk of Coronary Heart Disease. Arteriosclerosis and Thrombosis. 1991;11:1245-9.

Packard RR, Libby P. Inflammation in Atherosclerosis: From Vascular Biology to Biomarker Discovery and Risk Prediction. Clinical Chemistry. 2008;54:24-38.

Baldassarre D, Amato M, Bondioli A, Sirtori CR, Tremoli E. Carotid Artery Intima-Media Thickness Measured by Ultrasonography in Normal Clinical Practice Correlates Well with Atherosclerosis Risk Factors. Stroke. 2000;31:2426-30.

Wofford JL, Kahl FR, Howard GR, McKinney WM, Toole JF, Crouse JR. Relation of Extent of Extracranial Carotid Artery Atherosclerosis as Measured by B-mode Ultrasound to the Extent of Coronary Atherosclerosis. Arteriosclerosis and Thrombosis. 1991;11:1786-94.

Göksan B, Erkol G, Bozluolcay M, Ince B. Diabetes as a Determinant of High-Grade Carotid Artery Stenosis: Evaluation of 1,058 Cases by Doppler Sonography. Journal of Stroke and Cerebrovascular Diseases. 2001;10(6):252-6.

Cantú-Brito C, Rodríguez-Saldaña J, Reynoso-Marenco MT, Marmolejo-Henderson R, Barinagarrementeria-Aldatz F. Cardiovascular Risk Factors and Carotid Atherosclerosis Detected by Ultrasonography. Salud Publica Mex. 1999;41:452-9.

Shah Ebrahim DM, Papacosta O, Whincup P, Wannamethee G, Walker M, Nicolaides AN, et al. Carotid Plaque, Intima Media Thickness, Cardiovascular Risk Factors, and Prevalent Cardiovascular Disease in Men and Women. Stroke. 1999;30(4):841-50.

Su TC, Chien KL, Jeng JS, Chen MF, Hsu HC, Torng PL, et al. Age- and Gender-Associated Determinants of Carotid Intima-Media Thickness: A Community-Based Study. Journal of Atherosclerosis and Thrombosis. 2012;19(9):872-80.

Tanaka H, Nishino M, Ishida M, Fukunaga R, Sueyoshi K. Progression of Carotid Atherosclerosis in Japanese Patients with Coronary Artery Disease. Stroke. 1992; 23:946-51.

Hollander W. Role of Hypertension in Atherosclerosis and Cardiovascular Disease. American Journal of Cardiology. 1976;38(6):786-800.

Crouse JR, Goldbourt U, Evans G, Pinsky J, Sharrett AR, Sorlie P, et al. Risk Factors and Segment-Specific Carotid Arterial Enlargement in the Atherosclerosis Risk in Communities (ARIC) Cohort. Stroke. 1996;27(1):69-75.