Body Mass Index and In-Hospital Management and Outcome of Acute Myocardial Infarction BMI and In-Hospital Outcomes in AMI
Main Article Content
Abstract
Background: The association between body mass index (BMI) and the management and in-hospital outcomes of patients hospitalized for acute myocardial infarction (AMI) is unclear.
Objectives: We sought to determine the effect of BMI on the clinical presentation, management, and in-hospital outcomes of AMI patients.
Methods: This prospective cohort study included patients admitted with AMI at the Department of Cardiology, PIMS, Islamabad, between 1st March 2024 and 31st July 2024. Adult (aged ≥ 18 years) male and female patients with AMI confirmed by symptoms, electrocardiographic changes, and elevated cardiac biomarkers were included. Patients with incomplete medical records or those who left against medical advice were excluded.
Results: A total of 1,200 patients with AMI were included in this study and divided into four groups according to BMI: underweight (n=60), normal-weight (n=480), overweight (n=420), and obese (n=240). The baseline characteristics of the obese group indicated they were relatively younger than those in the other three groups (p=0.045). In multivariate logistic regression analysis, age (OR 1.05, 95% CI: 1.02-1.08, p=0.001) and obesity (OR 1.35, 95% CI 1.01-1.79, p=0.042) were significant factors.
Conclusion: These results indicate that although BMI may not affect the utilization of in-hospital treatments for AMI, it does influence the length of hospital stay and complications.
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References
World Health Organization. Cardiovascular Diseases (CVDs). Available at: https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds).
Khera R, Dharmarajan K, Wang Y, Lin Z, Bernheim SM, Wang Y, et al. Association of the Hospital Readmissions Reduction Program With Mortality Among Medicare Beneficiaries Hospitalized for Acute Myocardial Infarction, Heart Failure, and Pneumonia. JAMA Netw Open. 2021;4(1). doi:10.1001/jamanetworkopen.2020.30985
Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, et al. 2017 ESC Guidelines for the Management of Acute Myocardial Infarction in Patients Presenting With ST-Segment Elevation. Eur Heart J. 2018;39(2):119-77. doi:10.1093/eurheartj/ehx393
Jebb SA, Wells JC. Measuring Body Composition in Adults and Children. In: Handbook of Obesity. CRC Press; 2007. p. 19-43. doi:10.1201/9781420016691
Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, et al. Obesity and Cardiovascular Disease: Pathophysiology, Evaluation, and Effect of Weight Loss. Arterioscler Thromb Vasc Biol. 2006;26(5):968-76. doi:10.1161/01.ATV.0000216787.85457.f
Nuttall FQ. Body Mass Index: Obesity, BMI, and Health: A Critical Review. Nutr Today. 2015;50(3):117. doi:10.1097/NT.0000000000000092
Huang Y, Cai X, Mai W, Li M, Hu Y, Xu D. Association Between Obesity and Short- and Long-Term Mortality in Patients With Acute Myocardial Infarction: A Systematic Review and Meta-Analysis. Clin Cardiol. 2021;44(5):590-602. doi:10.1002/clc.23577
Bozkurt B, Hershberger RE, Butler J, Grady KL, Heidenreich PA, Isler ML, et al. 2021 ACC/AHA Key Data Elements and Definitions for Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Clinical Data Standards for Heart Failure). J Am Coll Cardiol. 2021;77(17):2053-2150. doi:10.1016/j.jacc.2021.02.038
Powell-Wiley TM, Poirier P, Burke LE, Després JP, Gordon-Larsen P, Lavie CJ, et al. Obesity and Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation. 2021;143(21). doi:10.1161/CIR.0000000000000973
Romero-Corral A, Somers VK, Sierra-Johnson J, Thomas RJ, Collazo-Clavell ML, Korinek J, et al. Accuracy of Body Mass Index in Diagnosing Obesity in the Adult General Population. Int J Obes. 2008;32(6):959-66. doi:10.1038/ijo.2008.11
De Schutter A, Lavie CJ, Milani RV, Ventura HO. The Impact of Obesity on Outcomes in Heart Failure With Preserved Ejection Fraction: A Systematic Review and Meta-Analysis. Prog Cardiovasc Dis. 2021;68:64-70. doi:10.1016/j.pcad.2021.05.002
Khan SS, Ning H, Wilkins JT, Allen N, Carnethon M, Berry JD, et al. Association of Body Mass Index With Lifetime Risk of Cardiovascular Disease and Compression of Morbidity. JAMA Cardiol. 2021;6(3):343-50. doi:10.1001/jamacardio.2020.5262
Angerås O, Albertsson P, Karason K, Råmunddal T, Matejka G, James SK. Evidence for Obesity Paradox in Patients With Acute Coronary Syndromes: A Report From the Swedish Coronary Angiography and Angioplasty Registry. Eur Heart J. 2013;34(5):345-53. doi:10.1093/eurheartj/ehs217
Lavie CJ, Milani RV, Ventura HO. Obesity and Cardiovascular Disease: Risk Factor, Paradox, and Impact of Weight Loss. J Am Coll Cardiol. 2009;53(21):1925-32. doi:10.1016/j.jacc.2008.12.068
Chiolero A, Faeh D, Paccaud F, Cornuz J. Consequences of Smoking for Body Weight, Body Fat Distribution, and Insulin Resistance. Am J Clin Nutr. 2008;87(4):801-9. doi:10.1093/ajcn/87.4.801
Drewnowski A, Specter SE. Poverty and Obesity: The Role of Energy Density and Energy Costs. Am J Clin Nutr. 2004;79(1):6-16. doi:10.1093/ajcn/79.1.6
Drewnowski A. Obesity and the Food Environment: Dietary Energy Density and Diet Costs. Am J Prev Med. 2004;27(3):154-62. doi:10.1016/j.amepre.2004.06.011
Neeland IJ, Poirier P, Després JP. Cardiovascular and Metabolic Heterogeneity of Obesity: Clinical Challenges and Implications for Management. Circulation. 2018;137(13):1391-406. doi:10.1161/CIRCULATIONAHA.117.029617
Grassi G, Dell'Oro R, Quarti-Trevano F, Scopelliti F, Seravalle G, Mancia G. Neuroadrenergic and Reflex Abnormalities in Hypertension and Their Implications in Treatment. J Hypertens. 2004;22(9):1711-4. doi:10.1097/00004872-200409000-00002
Amsterdam EA, Wenger NK, Brindis RG, Casey DE Jr, Ganiats TG, Holmes DR Jr, et al. 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes. J Am Coll Cardiol. 2014;64(24). doi:10.1016/j.jacc.2014.09.017
Bucholz EM, Rathore SS, Gosch K, Schoenfeld A, Jones PG, Buchanan DM, et al. Effect of Obesity on Mortality and Procedural Complications in Percutaneous Coronary Intervention Among Patients With Acute Myocardial Infarction. J Am Coll Cardiol. 2014;64(11):1042-51. doi:10.1016/j.jacc.2014.06.1152
Oreopoulos A, Padwal R, Kalantar-Zadeh K, Fonarow GC, Norris CM, McAlister FA. Body Mass Index and Mortality in Heart Failure: A Meta-Analysis. Am Heart J. 2008;156(1):13-22. doi:10.1016/j.ahj.2008.02.014
Fox CS, Evans JC, Larson MG, Kannel WB, Levy D. The Association of Obesity With Cardiovascular Disease Mortality in the Framingham Heart Study. Ann Intern Med. 2004;140(1):24-32. doi:10.7326/0003-4819-140-1-200401060-00008