Percutaneous Revascularization for Ischemic Left Ventricular Dysfunction
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Abstract
Background:
Ischemic left ventricular (LV) dysfunction, characterized by reduced ejection fraction due to coronary artery disease (CAD), is associated with high morbidity and mortality. Percutaneous coronary intervention (PCI) aims to restore blood flow in ischemic myocardium, potentially improving outcomes in this high-risk population.
Objective:
To evaluate the effects and safety of PCI in managing patients with ischemic LV dysfunction.
Methods:
This prospective single-center study was conducted at the Department of Cardiology, PIMS, Islamabad, from March 1, 2024, to July 31, 2024. A total of 225 patients with ischemic LV dysfunction (EF < 40%) and significant CAD were enrolled and divided into PCI (n = 123) and medical therapy (MT) (n = 102) groups. Exclusion criteria included non-ischemic cardiomyopathy, severe comorbidities, and recent myocardial infarction. Primary outcomes were EF improvement and MACE rates. Secondary outcomes included NYHA class improvement and quality of life assessed by the Minnesota Living with Heart Failure Questionnaire (MLHFQ).
Results:
The PCI group showed a significant EF improvement (8.1% vs. 3.2%, p < 0.01) and lower MACE rates (13.8% vs. 24.5%, p = 0.03). Quality of life improved more in the PCI group (MLHFQ score reduction, p < 0.01).
Conclusion:
PCI significantly improves LV function, reduces MACE, and enhances quality of life in patients with ischemic LV dysfunction compared to MT.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
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