The Effect of Laser-Assisted in Situ Keratomileusis on Endothelial Cell Count LASIK and Endothelial Cell Count

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Published: Sep 17, 2024
DOI: https://doi.org/10.61919/jhrr.v4i3.1398
Keywords:
LASIK, endothelial cell count, myopia, refractive surgery, corneal thickness, visual acuity, corneal health, specular microscopy, ophthalmology, patient outcomes.

Main Article Content

Khola Khan
Department of Ophthalmology, Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi, Pakistan
Abdul Rauf
Department of Ophthalmology, Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi, Pakistan
Ijlal Taimoor
Department of Ophthalmology, Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi, Pakistan
Teyyeb Azeem Janjua
Department of Ophthalmology, Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi, Pakistan
Umar Ijaz
Department of Ophthalmology, Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi, Pakistan
Farheen
Department of Ophthalmology, Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi, Pakistan
Muhammad Farrukh Habib
Department of Management Sciences, Shifa Tameer E Millat University, Islamabad, Pakistan.

Abstract

Background: LASIK is a popular refractive surgery for correcting myopia, but its impact on endothelial cell count (ECC) remains uncertain, with potential implications for corneal health.
Objective: To determine the effect of LASIK on ECC in myopic patients.
Methods: A cross-sectional study was conducted at Military Hospital, Rawalpindi, from January to July 2023. A total of 178 myopic patients (38.76% males, 61.24% females; mean age 25.21 ± 8.19 years) underwent LASIK. Baseline and post-procedural ECC were measured using specular microscopy at one week, one month, and three months post-LASIK. Central corneal thickness (CCT) and best corrected visual acuity (BCVA) were also assessed. Data analysis was performed using SPSS version 25, with paired t-tests for comparisons and significance set at p ≤ 0.05.
Results: Mean ECC decreased from 2897.49 ± 93.52 cells/mm² at baseline to 2892.36 ± 94.21 cells/mm² at one week, 2846.65 ± 93.80 cells/mm² at one month, and 2811.10 ± 90.66 cells/mm² at three months post-LASIK (p < 0.001). Mean CCT also significantly decreased at all time points (p < 0.001).
Conclusion: LASIK significantly reduces ECC, highlighting the need for careful postoperative monitoring of corneal health.

Article Details

How to Cite
Khola Khan, Abdul Rauf, Ijlal Taimoor, Teyyeb Azeem Janjua, Umar Ijaz, Farheen, & Muhammad Farrukh Habib. (2024). The Effect of Laser-Assisted in Situ Keratomileusis on Endothelial Cell Count: LASIK and Endothelial Cell Count. Journal of Health and Rehabilitation Research, 4(3), 1–4. https://doi.org/10.61919/jhrr.v4i3.1398
Issue
Vol. 4 No. 3 (2024): Volume 4, Issue 3 - July to September 2024
Section
Articles
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This work is licensed under a Creative Commons Attribution 4.0 International License.

References

Rajabpour M, Kangari H, Pesudovs K, Khorrami-Nejad M, Rahmani S, Mohaghegh S, et al. Refractive error and vision related quality of life. BMC Ophthalmol. 2024;24(1):83. https://doi.org/10.1186/s12886-024-03350-8.

Mohammed Dhaiban TS, Ummer FP, Khudadad H, Veettil ST. Types and presentation of refractive error among individuals aged 0-30 years: Hospital-based cross-sectional study, Yemen. Adv Med. 2021;2021:5557761. https://doi.org/10.1155/2021/5557761.

Latif MZ, Khan MA, Afzal S, Gillani SA, Chouhadry MA. Prevalence of refractive errors; an evidence from the public high schools of Lahore, Pakistan. J Pak Med Assoc. 2019;69(4):464-467.

Leske DA, Hatt SR, Castañeda YS, Wernimont SM, Liebermann L, Cheng-Patel CS, et al. Eye-related quality of life and functional vision in children wearing glasses. J AAPOS. 2020;24(2):91.e1-91.e6. https://doi.org/10.1016/j.jaapos.2019.12.010.

Wallerstein A, Kam JWK, Gauvin M, Adiguzel E, Bashour M, Kalevar A, et al. Refractive, visual, and subjective quality of vision outcomes for very high myopia LASIK from - 10.00 to - 13.50 diopters. BMC Ophthalmol. 2020;20(1):234. https://doi.org/10.1186/s12886-020-01481-2.

Sahay P, Bafna RK, Reddy JC, Vajpayee RB, Sharma N. Complications of laser-assisted in situ keratomileusis. Indian J Ophthalmol. 2021;69(7):1658-1669. https://doi.org/10.4103/ijo.IJO_1872_20.

Al-Amri AR. Clinical knowledge of post-LASIK corneal ectasia: A review. Bahrain Med Bull. 2021;43(1):390-394.

Hashmani S, Hashmani N, Kumar S, Kumar S, Dhomeja V, Razak S, et al. Reasons for refusing laser-assisted in situ keratomileusis in a Pakistani population. Cureus. 2017;9(6):e1391. https://doi.org/10.7759/cureus.1391.

Wan Q, Wang D, Ye H, Tang J, Han Y. A review and meta-analysis of corneal cross-linking for post-laser vision correction ectasia. J Curr Ophthalmol. 2017;29(3):145-153. https://doi.org/10.1016/j.joco.2017.02.008.

El-Din Mahmoud MS, Hassan EE, Abdelhalim AS. Evaluation of corneal endothelium after myopic laser-assisted in situ keratomileusis (LASIK) with accelerated cross-linking (CXL) in diabetic patients. Open Ophthalmol J. 2021;15:329-337. https://doi.org/10.2174/1874364102115010329.

Lang M, Cao KW, Liu T, Zhu Y, Ye J. Five-year results of refractive outcomes and vision-related quality of life after SMILE for the correction of high myopia. Int J Ophthalmol. 2021;14(9):1365-1370. https://doi.org/10.18240/ijo.2021.09.11.

Bamashmus MA, Hubaish K, Alawad M, Alakhlee H. Functional outcome and patient satisfaction after laser in situ keratomileusis for correction of myopia and myopic astigmatism. Middle East Afr J Ophthalmol. 2015;22(1):108-114. https://doi.org/10.4103/0974-9233.148359.

He G, Bala C. Ray-tracing-guided myopic LASIK: real-world clinical outcomes. J Cataract Refract Surg. 2023;49(11):1140-1146. https://doi.org/10.1097/j.jcrs.0000000000001286.

Li SM, Kang MT, Wang NL, Abariga SA. Wavefront excimer laser refractive surgery for adults with refractive errors. Cochrane Database Syst Rev. 2020;12(12):CD012687. https://doi.org/10.1002/14651858.CD012687.pub2.

Bullimore MA, Lee SS, Schmid KL, Rozema JJ, Leveziel N, Mallen EAH, et al. IMI-Onset and Progression of Myopia in Young Adults. Invest Ophthalmol Vis Sci. 2023;64(6):2. https://doi.org/10.1167/iovs.64.6.2.

Lee SS, Mackey DA. Prevalence and risk factors of myopia in young adults: review of findings from the Raine study. Front Public Health. 2022;10:861044. https://doi.org/10.3389/fpubh.2022.861044.

Czepita M, Czepita D, Safranow K. Role of gender in the prevalence of myopia among Polish schoolchildren. J Ophthalmol. 2019;2019:9748576. https://doi.org/10.1155/2019/9748576.

Gessesse SA, Teshome AW. Prevalence of myopia among secondary school students in Welkite town: South-Western Ethiopia. BMC Ophthalmol. 2020;20(1):176. https://doi.org/10.1186/s12886-020-01457-2.

Moshirfar M, Durnford K, Megerdichian A, Thomson A, Martheswaran T, West W Jr, et al. Refractive outcomes after LASIK for the treatment of mixed astigmatism with the Allegretto WaveLight EX500. Ophthalmol Ther. 2022;11(2):785-795. https://doi.org/10.1007/s40123-022-00472-4.

Kubravi SH, Qureshi ST, Nawaz S, Nazir A, Kawoosa K. Changes in central corneal thickness and endothelial cell count after LASIK. Brit J Med Med Res. 2017;19(3):1-8. https://doi.org/10.9734/BJMMR/2017/29973.

Baig MJ, Mahmood K, Khan T, Qazi ZA. Effect of Lasik on endothelial cell count in patients treated for myopia. Pak J Ophthalmol. 2010;26(1):39-43.

Simaroj P, Kosalprapai K, Chuckpaiwong V. Effect of laser in situ keratomileusis on the corneal endothelium. J Refract Surg. 2003;19(2 Suppl):S237-S240. https://doi.org/10.3928/1081-597X-20030302-13.

Muñoz G, Albarrán-Diego C, Sakla HF, Ferrer-Blasco T, Javaloy J. Effects of LASIK on corneal endothelium using the 15-kHz IntraLase femtosecond laser. J Refract Surg. 2011;27(9):672-627. https://doi.org/10.3928/1081597X-20110415-02

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