Hyperthermia in Patients Presented with Ischemic Stroke: Frequency and Clinical Presentation Hyperthermia and Stroke Severity

Main Article Content

Waleed Abbasi
Noor Ul Huda
Umar Azam Ali

Abstract

Background: Hyperthermia is a common complication in acute ischemic stroke and is associated with worsened outcomes due to increased metabolic demand, oxidative stress, and neuroinflammation.
Objective: This study aimed to determine the frequency of hyperthermia in acute ischemic stroke patients and explore its association with stroke severity and clinical presentation.
Methods: A prospective observational cohort study was conducted at Ayub Teaching Hospital from September 2023 to March 2024, including 150 adults diagnosed with acute ischemic stroke within 24 hours. Hyperthermia was defined as a body temperature >37.5°C, measured every 4 hours for 48 hours. Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS) and categorized into mild, moderate, or severe. Statistical analysis was performed using chi-square tests.
Results: Hyperthermia occurred in 14.7% (n=22) of patients. It was more frequent in severe strokes (50.0% vs. 18.2% in mild, p=0.001). Clinically, 40.9% had tachycardia, 36.4% had tachypnea, and 22.7% exhibited neurological deficits.
Conclusion: Hyperthermia is significantly associated with severe stroke presentations, underscoring the need for vigilant temperature management to improve outcomes.

Article Details

How to Cite
Waleed Abbasi, Noor Ul Huda, & Umar Azam Ali. (2024). Hyperthermia in Patients Presented with Ischemic Stroke: Frequency and Clinical Presentation: Hyperthermia and Stroke Severity. Journal of Health and Rehabilitation Research, 4(3), 1–4. https://doi.org/10.61919/jhrr.v4i3.1439
Section
Articles

References

Puthenpurakal A, Crussell J. Stroke 1: Definition, Burden, Risk Factors and Diagnosis. Nurs Times. 2017;113(11):43-7.

Hajat C, Hajat S, Sharma P. Effects of Poststroke Pyrexia on Stroke Outcome: A Meta-Analysis of Studies in Patients. Stroke. 2000;31(2):410-4.

Torres-Aguila NP, Carrera C, Muiño E, Cullell N, Cárcel-Márquez J, Gallego-Fabrega C, et al. Clinical Variables and Genetic Risk Factors Associated with the Acute Outcome of Ischemic Stroke: A Systematic Review. J Stroke. 2019;21(3):276-9.

Wu X, Zou Y, You S, Zhang Y. Distribution of Risk Factors of Ischemic Stroke in Chinese Young Adults and Its Correlation with Prognosis. BMC Neurol. 2022;22(1):26-31.

Hurwitz MD. Hyperthermia and Immunotherapy: Clinical Opportunities. Int J Hyperthermia. 2019;36(2):4-9.

Hopkins PM, Girard T, Dalay S, Jenkins B, Thacker A, Patteril M, et al. Malignant Hyperthermia 2020: Guideline from the Association of Anaesthetists. Anaesthesia. 2021;76(5):655-64.

Horseman M, Panahi L, Udeani G, Tenpas AS, Verduzco R, Patel PH, et al. Drug-Induced Hyperthermia Review. Cureus. 2022;14(7).

Nye EA, Edler JR, Eberman LE, Games KE. Optimizing Cold-Water Immersion for Exercise-Induced Hyperthermia: An Evidence-Based Paper. J Athl Train. 2016;51(6):500-1.

Phipps MS, Desai RA, Wira C, Bravata DM. Epidemiology and Outcomes of Fever Burden Among Patients with Acute Ischemic Stroke. Stroke. 2011;42(12):3357-62.

Zeb F, Qadir I, Zafar S, Qureshi SA, Khan A, Parveiz S. Frequency of Hyperthermia in Acute Ischemic Stroke Patients Presenting to Tertiary Care Hospital. Prof Med J. 2023;30(7):841-5.

Wood TR, Gundersen JK, Falck M, Maes E, Osredkar D, Løberg EM, et al. Variability and Sex-Dependence of Hypothermic Neuroprotection in a Rat Model of Neonatal Hypoxic–Ischaemic Brain Injury: A Single Laboratory Meta-Analysis. Sci Rep. 2020;10(1):10833.

Saini M, Saqqur M, Kamruzzaman A, Lees KR, Shuaib A. Effect of Hyperthermia on Prognosis After Acute Ischemic Stroke. Stroke. 2009;40(9):3051-9.

Chen LF, Cheng YC, Hsu LC. Bacterial Pneumonia Following Acute Ischemic Stroke. J Chin Med Assoc. 2013;76(1):78-82.

Campos F, Sobrino T, Vieites-Prado A, Pérez-Mato M, Rodríguez-Yáñez M, Blanco M, et al. Hyperthermia in Human Ischemic and Hemorrhagic Stroke: Similar Outcome, Different Mechanisms. PLoS One. 2013;8(11).

Bernd K, Rainer K. Temperature Management in Stroke: An Unsolved, but Important Topic. Cerebrovasc Dis. 2011;31(5):532-43.

Tahir RA, Pabaney AH. Therapeutic Hypothermia and Ischemic Stroke: A Literature Review. Surg Neurol Int. 2016;7:20.

Kim JY, Yenari MA. Hypothermia for Treatment of Stroke. Brain Circ. 2015;1(2):14-25.

Mrozek S, Vardon F, Geeraerts T. Brain Temperature: Physiology and Pathophysiology After Brain Injury. Anesthesiol Res Pract. 2012;2012:989487.