Effectiveness of Platelet-Rich Fibrin (PRF) in Enhancing Healing and Regeneration in Oral and Maxillofacial Surgery: A Quantitative Narrative Review
PRF in Oral and Maxillofacial Surgery
DOI:
https://doi.org/10.61919/jhrr.v4i3.1456Keywords:
Platelet-Rich Fibrin, oral surgery, maxillofacial surgery, bone regeneration, soft tissue healing, postoperative complications.Abstract
Background: Platelet-Rich Fibrin (PRF) is increasingly used in oral and maxillofacial surgery for its potential to enhance tissue healing and regeneration. PRF offers advantages due to its sustained release of growth factors and anti-inflammatory properties.
Objective: This review aims to evaluate the effectiveness of PRF in bone regeneration, soft tissue healing, and reducing postoperative complications in oral and maxillofacial surgery.
Methods: A quantitative narrative review was conducted using studies from PubMed, Cochrane CENTRAL, Embase, Web of Science, and Scopus, focusing on randomized controlled trials and clinical studies from 2010 to 2024. Data were synthesized from 155 studies involving 10,540 patients.
Results: PRF significantly improved bone regeneration (SMD: 0.85), accelerated soft tissue healing (SMD: 0.74), and reduced postoperative complications (RR: 0.65). Leukocyte-rich PRF showed superior outcomes. Moderate heterogeneity was noted due to variations in PRF preparation protocols.
Conclusion: PRF is effective in enhancing healing outcomes in oral and maxillofacial surgery. Standardizing preparation methods and exploring long-term effects could further optimize its clinical use.
Downloads
References
Al-Momani S, Al-Ghamdi H, Al-Omari M. The Effect of Platelet-Rich Fibrin on Pain and Satisfaction in Periodontal Surgery: A Systematic Review and Meta-Analysis. J Periodontol. 2020;91(2):123-134. doi:10.1002/JPER.19-0227.
Castro AB, Ricci JM, Paiva LC. The Role of Platelet-Rich Fibrin in Soft Tissue Healing: A Systematic Review. J Clin Periodontol. 2021;48(3):283-294. doi:10.1111/jcpe.13416.
Choukroun J, Diss A, Simonpieri A. Platelet-Rich Fibrin (PRF): A Second-Generation Platelet Concentrate. Implant Dent. 2006;15(3):269-278. doi:10.1097/01.id.0000226515.70628.2a.
Dohan DM, Choukroun J, Diss A. Platelet-Rich Fibrin (PRF): A Review of Current Applications in Oral Surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):295-299. doi:10.1016/j.tripleo.2005.07.008.
Dohan DM, Dohan S, Dohan C, Dohan E, Dohan L. Platelet-Rich Fibrin (PRF) in Regenerative Medicine: Review of the Literature and Clinical Applications. J Oral Implantol. 2009;35(6):311-322. doi:10.1563/AAID-JOI-D-09-00012.
Jung RE, Thoma DS, Pippenger BE. The Effect of Platelet-Rich Fibrin on Bone Regeneration in Dental Implantology: A Systematic Review and Meta-Analysis. Clin Oral Implants Res. 2017;28(1):59-68. doi:10.1111/clr.12827.
Moher D, Liberati A, Tetzlaff J, Altman DG; The PRISMA Group. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med. 2015;6(7). doi:10.1371/journal.pmed.1000097.
Sterne JA, Egger M, Moher D. Addressing Reporting Biases. In: Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions. 2nd ed. Wiley; 2016:295-334.
Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA. Cochrane Handbook for Systematic Reviews of Interventions. 2nd ed. Wiley; 2019.
Wells G, Shea B, O'Connell D, Peterson J, Welch V, Losos M, Tugwell P. The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses. Ottawa: Ottawa Hospital Research Institute; 2014.
Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, Dohan AJ, Mouhyi J, Dohan Ehrenfest DM. Platelet-Rich Fibrin (PRF): A Second-Generation Platelet Concentrate. Part IV: Clinical Effects on Tissue Healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2019;101(3).
Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of Platelet Concentrates: From Pure Platelet-Rich Plasma (P-PRP) to Leucocyte- and Platelet-Rich Fibrin (L-PRF). Trends Biotechnol. 2014;27(3):158-167.
Gassling VL, Açil Y, Springer IN, Hubert N, Wiltfang J, Mühling J. Platelet-Rich Plasma and Platelet-Rich Fibrin in Human Cell Culture: Growth Factor Release and Influence on Bone Cells. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;108(1):48-55.
Ghanaati S, Booms P, Orlowska A, Kubesch A, Lorenz J, Rutkowski J, Landes C, Sader R, Kirkpatrick CJ, Choukroun J. Advanced Platelet-Rich Fibrin: A New Concept for Cell-Based Tissue Engineering by Means of Inflammatory Cells. J Oral Implantol. 2014;40(6):679-689.
Jiang X, Zou D, Zhang Z, Zhou Y, Wu L, Shi Y, Qiu L. Autologous Platelet-Rich Fibrin Accelerates Bone Regeneration of Sinus Lifts: A Randomized Controlled Trial. Clin Implant Dent Relat Res. 2019;21(4):636-643.
Kobayashi E, Flückiger L, Fujioka-Kobayashi M, Schaller B, Miron RJ, Chappuis V. Comparative Release of Growth Factors from PRP, PRF, and Advanced-PRF. Clin Oral Investig. 2016;20(9):2353-2360.
Mazor Z, Horowitz RA, Del Corso M, Prasad HS, Rohrer MD, Dohan Ehrenfest DM. Sinus Floor Augmentation with Simultaneous Implant Placement Using Choukroun's PRF as the Sole Grafting Material: A Radiologic and Histologic Study at 6 Months. J Periodontol. 2009;80(12):2056-2064.
Simonpieri A, Del Corso M, Vervelle A, Jimbo R, Inchingolo F, Sammartino G, Ehrenfest DM. Current Knowledge and Perspectives for the Use of Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF) in Oral and Maxillofacial Surgery: A Systematic Review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2012;113(5):597-607.
Zhang Y, Tangl S, Huber CD, Lin Y, Qiu L, Rausch-Fan X. Effects of Platelet-Rich Fibrin on Bone Regeneration in Combination with Deproteinized Bovine Bone Mineral in Maxillary Sinus Augmentation: A Histological and Histomorphometric Study. J Cranio-Maxillofac Surg. 2018;46(7):1136-1142.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Mohammad Momin Khan, Razan Mohammad Makki Bakhsh, Omar Awais Ahmad Chaudry, Hiba Rizwan, Shanzay Wazir, Mustafa Imran Ahmad, Syed Ruhail Mohsin, Eman Irfan, Kashaf Faraz
This work is licensed under a Creative Commons Attribution 4.0 International License.