Exploring the Anti-Carcinogenic Effect of Choline in Limiting the Progression of Breast Cancer in Females Anti-Carcinogenic Effect of Choline in Breast Cancer

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Published: Sep 29, 2024
DOI: https://doi.org/10.61919/jhrr.v4i3.1609
Keywords:
Breast Cancer, Choline, Phosphatidyl-choline, Choline Metabolism, One-Carbon Metabolism, Dietary Intake, Cancer Progression

Main Article Content

Warda Mehmood
Department of Nutritional Sciences, Government College University Faisalabad, 38000, Punjab, Pakistan
Musfirah Shahid
Department of Nutritional Sciences, Government College University Faisalabad, 38000, Punjab, Pakistan
Menahill Rashid
Department of Nutritional Sciences, Government College University Faisalabad, 38000, Punjab, Pakistan
Fizza Tariq
Department of Nutritional Sciences, Government College University Faisalabad, 38000, Punjab, Pakistan
Maham Iftikhar Chaudary
National Institute of Food Science and Technology (NIFSAT), University of Agriculture Faisalabad, 38000, Punjab, Pakistan.
Muhammad Hamza
Department of Nutritional Sciences, Government College University Faisalabad, 38000, Punjab, Pakistan

Abstract

Background: Breast cancer is one of the most common cancers among females worldwide, influenced by genetic, environmental, and dietary factors. Choline, an essential nutrient, plays a crucial role in cell membrane integrity and DNA methylation, which are significant for maintaining genomic stability.
Objective: This review aims to explore the anti-carcinogenic effects of choline in limiting the progression of breast cancer.
Methods: A narrative review was conducted using electronic databases, including PubMed, Google Scholar, and ScienceDirect, to identify relevant studies. Data were extracted from observational studies, clinical trials, and meta-analyses that focused on choline intake and breast cancer risk. Studies were appraised using established quality assessment tools.
Results: Evidence suggests that adequate choline intake is linked to reduced breast cancer risk through its role in DNA methylation and gene regulation. However, findings are inconsistent due to genetic variations and methodological differences.
Conclusion: While choline shows potential as a protective nutrient, further research is needed to clarify its role in breast cancer prevention, considering genetic and dietary variations

Article Details

How to Cite
Warda Mehmood, Musfirah Shahid, Menahill Rashid, Fizza Tariq, Maham Iftikhar Chaudary, & Muhammad Hamza. (2024). Exploring the Anti-Carcinogenic Effect of Choline in Limiting the Progression of Breast Cancer in Females: Anti-Carcinogenic Effect of Choline in Breast Cancer. Journal of Health and Rehabilitation Research, 4(3). https://doi.org/10.61919/jhrr.v4i3.1609
Issue
Vol. 4 No. 3 (2024): Volume 4, Issue 3 - July to September 2024
Section
Articles
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This work is licensed under a Creative Commons Attribution 4.0 International License.

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