In-Hospital Mortality in Diffuse Axonal Injury: Identifying Key Risk Factors for Improved Outcomes Mortality Predictors in Diffuse Axonal Injury

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Published: Sep 28, 2024
DOI: https://doi.org/10.61919/jhrr.v4i3.1613
Keywords:
Diffuse axonal injury, traumatic brain injury, in-hospital mortality, clinical predictors, neurological symptoms, seizure management, Glasgow Coma Scale, computed tomography.

Main Article Content

Pirah Jalil Korai
Consultant Neurosurgeon, Chandka Medical College Hospital Larkana, Pakistan
Muhammad Salah Jamal
Senior Registrar, Shaheed Mohtarma Benazir Bhutto Medical College Karachi, Pakistan
Sajid Hussain
Consultant Orthopaedic Surgeon, Chandka Medical College Hospital Larkana, Pakistan
Muhammad Ali Jamali
Assistant Professor, People's University of Medical and Health Sciences, Pakistan
Shuja Shaukat
Registrar, Neurosurgery Department, Civil Hospital Karachi, Pakistan
Shakeela Kalhoro
Lecturer, SMBBMU Larkana, Pakistan
Veengas Baloch
Chandka Medical College Hospital Larkana, Pakistan

Abstract

Background: Diffuse axonal injury (DAI) is a severe subtype of traumatic brain injury associated with high morbidity and mortality. Identifying key clinical predictors is crucial to improve outcomes in resource-limited settings.
Objective: This study aimed to evaluate in-hospital mortality and identify key clinical predictors of mortality in patients with DAI.
Methods: A prospective observational cohort study was conducted from April 2023 to March 2024 at the Neurosurgical Ward, Jinnah Postgraduate Medical Center, Karachi. A total of 102 patients aged 18-70 years with Glasgow Coma Scale (GCS) scores <8 and confirmed DAI via computed tomography (CT) within 12 hours of admission were included. Data on demographics, clinical symptoms, and outcomes were analyzed using chi-square tests, logistic regression, and Kaplan-Meier survival analysis in SPSS version 25.
Results: The in-hospital mortality rate was 9.8% (10 patients). Seizures (OR = 9.52, p<0.001), papilledema (OR = 4.30, p=0.010), and meningismus (OR = 3.10, p=0.026) were significant predictors of mortality.
Conclusion: Seizures, papilledema, and meningismus were identified as strong predictors of mortality in DAI. Early intervention targeting these symptoms is essential to improve survival.

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How to Cite
Pirah Jalil Korai, Muhammad Salah Jamal, Sajid Hussain, Muhammad Ali Jamali, Shuja Shaukat, Shakeela Kalhoro, & Veengas Baloch. (2024). In-Hospital Mortality in Diffuse Axonal Injury: Identifying Key Risk Factors for Improved Outcomes: Mortality Predictors in Diffuse Axonal Injury. Journal of Health and Rehabilitation Research, 4(3). https://doi.org/10.61919/jhrr.v4i3.1613
Issue
Vol. 4 No. 3 (2024): Volume 4, Issue 3 - July to September 2024
Section
Articles
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This work is licensed under a Creative Commons Attribution 4.0 International License.

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