Lipid Profile in Stroke Patients Presenting in Emergency Department: Lipid Profile in Stroke Patients

Syeda Nida Batool; Aqsa Abdul Qader; Khurram Mehmood; Syeda Fatimah Zareen; Hamd Ullah Khan; Hammad Shafique

doi:10.61919/jhrr.v4i3.1624

Authors

Syeda Nida Batool Postgraduate Trainee Emergency Medicine, Department of Emergency Medicine, Combined Military Hospital (CMH), Rawalpindi, Pakistan
Aqsa Abdul Qader House Officer, Department of Emergency Medicine, Combined Military Hospital (CMH), Rawalpindi, Pakistan
Khurram Mehmood House Officer, Department of Emergency Medicine, Pakistan Emirates Military Hospital, Rawalpindi, Pakistan
Syeda Fatimah Zareen Assistant Professor Internal Medicine and Head of the Department, Department of Emergency Medicine, Combined Military Hospital (CMH), Rawalpindi, Pakistan
Hamd Ullah Khan Training Medical Officer, Department of Medicine, Capital Hospital, Islamabad, Pakistan
Hammad Shafique Medical Officer, Medical ICU, Safari Hospital, Rawalpindi, Pakistan

DOI:

https://doi.org/10.61919/jhrr.v4i3.1624

Keywords:

Dyslipidemia, Stroke, Ischemic Stroke, Hemorrhagic Stroke, Lipid Profile, Emergency Department, Stroke Prevention, Cardiovascular Risk Factors.

Abstract

Background: Dyslipidemia is a significant modifiable risk factor associated with stroke, contributing to increased morbidity and mortality worldwide. The high prevalence of lipid abnormalities in stroke patients highlights the need for targeted preventive strategies.
Objective: To investigate the prevalence of dyslipidemia and its association with different stroke types among patients presenting in the emergency department.
Methods: A prospective cross-sectional study was conducted on 440 acute stroke patients at the Emergency Department of CMH Rawalpindi from January 2022 to December 2023. Stroke was confirmed using CT imaging, and lipid profiles were assessed through serum analysis. Participants were categorized into ischemic and hemorrhagic stroke groups. Data were analyzed using SPSS version 25, with p < 0.05 considered statistically significant.
Results: Of 440 patients (mean age: 50.83 ± 11.97 years), 314 (71.4%) were male and 126 (28.6%) females. Ischemic stroke was found in 347 (78.9%), and hemorrhagic stroke in 93 (21.1%) patients. Hypertriglyceridemia was more prevalent in ischemic stroke (66.3%) than in hemorrhagic stroke (46.2%) (p < 0.001). Hypertension was significantly higher in hemorrhagic stroke (86%) compared to ischemic stroke (43.2%) (p < 0.001).
Conclusion: Dyslipidemia is highly prevalent among stroke patients, with distinct patterns in ischemic and hemorrhagic stroke, needing early lipid management for stroke prevention.

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References

Jacob MA, Ekker MS, Allach Y, Cai M, Aarnio K, Arauz A, et al. Global Differences in Risk Factors, Etiology, and Outcome of Ischemic Stroke in Young Adults—A Worldwide Meta-Analysis: The GOAL Initiative. Neurology. 2022;98(6).

Guzik A, Bushnell C. Stroke Epidemiology and Risk Factor Management. Continuum: Lifelong Learning in Neurology. 2017;23(1):15-39.

Buck BH, Akhtar N, Alrohimi A, Khan K, Shuaib A. Stroke Mimics: Incidence, Aetiology, Clinical Features and Treatment. Ann Med. 2021;53(1):420-36.

Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS. Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis. Stroke. 2021;52(3):931-6.

Esposito E, Shekhtman G, Chen P. Prevalence of Spatial Neglect Post-Stroke: A Systematic Review. Ann Phys Rehabil Med. 2021;64(5):101459.

Rahayu UB, Wibowo S, Setyopranoto I, Romli MH. Effectiveness of Physiotherapy Interventions in Brain Plasticity, Balance and Functional Ability in Stroke Survivors: A Randomized Controlled Trial. NeuroRehabilitation. 2020;47(4):463-70.

Turana Y, Tengkawan J, Chia YC, Nathaniel M, Wang JG, Sukonthasarn A, et al. Hypertension and Stroke in Asia: A Comprehensive Review from HOPE Asia. J Clin Hypertens. 2021;23(3):513-21.

Diener HC, Hankey GJ. Primary and Secondary Prevention of Ischemic Stroke and Cerebral Hemorrhage: JACC Focus Seminar. J Am Coll Cardiol. 2020;75(15):1804-18.

Arvanitis M, Lowenstein CJ. Dyslipidemia. Ann Intern Med. 2023;176(6):81-96.

Khan RS, Nawaz M, Khan S, Raza HA, Nazir T, Anwar MS, et al. Prevalence of Dyslipidemia in Ischemic Stroke Patients: A Single-Center Prospective Study from Pakistan. Cureus. 2022;14(6).

Mahmood A, Sharif MA, Khan MN, Ali UZ. Comparison of Serum Lipid Profile in Ischaemic and Haemorrhagic Stroke. J Coll Physicians Surg Pak. 2010;20(5):317-20.

Aradine E, Hou Y, Cronin CA, Chaturvedi S. Current Status of Dyslipidemia Treatment for Stroke Prevention. Curr Neurol Neurosci Rep. 2020;20(8):31.

Gajurel BP, Gurung A, Ojha R, Rajbhandari R, Karn R. Dyslipidemia and Obesity in Ischemic Stroke. Cureus. 2023;15(9).

Khan RS, Nawaz M, Khan S, Raza HA, Nazir T, Anwar MS, et al. Prevalence of Dyslipidemia in Ischemic Stroke Patients: A Single-Center Prospective Study from Pakistan. Cureus. 2022;14(6).

Nussbaumerová B. Hypertension and Dyslipidemia Treatment in Stroke. Vnitr Lek. 2022;68(3):172-7.

Buonacera A, Stancanelli B, Malatino L. Stroke and Hypertension: An Appraisal from Pathophysiology to Clinical Practice. Curr Vasc Pharmacol. 2019;17(1):72-84.

Maida CD, Daidone M, Pacinella G, Norrito RL, Pinto A, Tuttolomondo A. Diabetes and Ischemic Stroke: An Old and New Relationship—An Overview of the Close Interaction between These Diseases. Int J Mol Sci. 2022;23(4):2011.

Baral S, Pokhrel A, Kshetri BKS, Regmi P, Gyawali P. Dyslipidemia among Patients with Ischemic Stroke in the Department of Medicine of a Tertiary Care Centre: A Descriptive Cross-Sectional Study. J Nepal Med Assoc. 2022;60(250):511-6.

Khadka T, Giri GK, Sherpa P, Ghimire U, Parajuli S, Pudasaini A, et al. Dyslipidemia among Patients with Ischemic Stroke Admitted to the Department of Medicine of a Tertiary Care Centre. J Nepal Med Assoc. 2023;61(265):718-22.

Lipid Profile in Stroke Patients Presenting in Emergency Department