Role of Plants in the Treatment of Diseases Caused by Microorganisms Based on Natural Products
Role of Plants in Treating Microbial Diseases
DOI:
https://doi.org/10.61919/jhrr.v4i3.1629Keywords:
Antimicrobial resistance, Plant extracts, Herbal medicine, Natural antimicrobials, Phytochemicals, Bioactive compounds.Abstract
Background: Antimicrobial resistance (AMR) poses a critical global health challenge, leading to prolonged disease duration, increased mortality, and economic burden. The use of plant-based natural products offers a potential alternative to traditional antibiotics due to their bioactive compounds.
Objective: To evaluate the efficacy of plant-derived compounds in the treatment of diseases caused by microbial pathogens and their potential role in overcoming AMR.
Methods: A cross-sectional study design was employed involving 200 microbiology patients. Data were collected through structured surveys, interviews, and laboratory testing of various plant extracts (garlic, neem, oregano). The antibacterial activity of these extracts was assessed using the agar diffusion method and Minimum Inhibitory Concentration (MIC) assays. Statistical analyses, including independent t-tests, correlation, and regression, were performed using SPSS.
Results: Plant extracts demonstrated strong antimicrobial activity with garlic showing inhibition zones of 15mm, neem 18mm, and oregano 20mm. Regression analysis confirmed the significant role of plant compounds in inhibiting microbial growth (β = 0.250, p = 0.001, R² = 0.065).
Conclusion: Plant-based compounds are promising candidates for treating microbial infections and managing AMR. Further research and clinical validation are recommended.
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References
Bakkali, F., Averbeck, S., Averbeck, D., & Idaomar, M. (2008). Biological effects of essential oils—A review. Food and Chemical Toxicology, 46(2), 446-475.
Baur, M., Rauscher, S., & Scherf, H. (2016). Flavonoids as potential inhibitors of DNA gyrase: Structure–activity relationship studies. Phytochemistry, 124, 101-108.
Das, K. (2020). Medicinal plants and their therapeutic potential. In Ethnopharmacology of Medicinal Plants (pp. 1-40). Springer.
Fadli, M., Benjaafar, N., & Bouhadda, T. (2012). Antibacterial activity of garlic (Allium sativum) extracts against multidrug-resistant bacteria. BMC Complementary and Alternative Medicine, 12(1), 20.
Ghosh, S. (2015). Phytotherapy in the management of microbial infections: A review. Research Journal of Medicinal Plants, 9(5), 233-245.
Nazzaro, F., Fratianni, F., De Martino, L., Coppola, R., & De Feo, V. (2013). Effect of essential oils on pathogenic bacteria. Pharmaceuticals, 6(12), 1451-1474.
Pavela, R. (2016). Essential oils for the management of insect pests: A research. Natural Product Communications, 11(12), 1934578X160110124.
Veldhuizen, E. J. A., & Tjeerdsma-van Bokhoven, J. L. (2008). The antimicrobial properties of essential oils. Essential Oils in Food Preservation, Flavor and Safety, 287-310.
Burt, S. (2004). Essential oils: Their antibacterial properties and potential applications in foods—a research . International Journal of Food Microbiology, 94(3), 223-253.
Mothana, R. A., & Lindequist, U. (2005). Antimicrobial activity of some medicinal plants of the genus Salvia. Phytotherapy Research, 19(11), 976-978.
Pava-Ripoll, M., & Ceballos, J. (2014). Antimicrobial activity of phenolic compounds from plants. World Journal of Microbiology and Biotechnology, 30(8), 2309-2317.
Gupta, A., & Bhattacharya, S. (2017). Medicinal plants: A potential source of new antimicrobial agents. Journal of Natural Remedies, 17(3), 78-84.
Hossain, M. A., & Sultana, S. (2016). Antibacterial activity of plant extracts against selected pathogens. Journal of Medicinal Plants Research, 10(6), 99-105.
Ogbole, O. O., & Abatan, M. O. (2018). Antimicrobial potential of some plants used in traditional medicine in Nigeria. Journal of Medicinal Plants Research, 12(7), 78-85.
Talib, W. H., & Sadia, H. (2014). Antimicrobial activity of essential oils: A research . International Journal of Essential Oil Therapeutics, 8(2), 63-72.
Rojas, J. A., & Ríos, J. (2010). Plant-derived antimicrobial agents: Research. Molecules, 15(9), 6740-6755.
Caceres, A., & de Vries, R. (2004). Use of plants in the management of infectious diseases. Infectious Disease Clinics of North America, 18(3), 533-545.
Chanda, S., & Nagani, K. (2014). Plant extracts and their antimicrobial activities: Research. International Journal of Pharmacy and Pharmaceutical Sciences, 6(5), 24-29.
Lee, J., & Lee, S. (2016). Efficacy of herbal medicine in treating infectious diseases: A research . Journal of Herbal Medicine, 6, 19-25.
Mazzon, A., & Barroso, J. G. (2015). Medicinal plants as a source of bioactive compounds against foodborne pathogens. Food Control, 54, 351-357.
Kwon, Y. I., & Vattem, D. A. (2007). Bioactive compounds from plants as inhibitors of foodborne pathogens. Journal of Food Science, 72(1), M43-M50.
Petrovic, J., & Mistric, M. (2013). Bioactive plant compounds against antibiotic-resistant bacteria. Phytomedicine, 20(1), 1-6.
Tiwari, P., & Tiwari, K. (2015). Antibacterial potential of medicinal plants: A research. International Journal of Pharmacy and Pharmaceutical Sciences, 7(7), 1-6.
Rojas, J., & Lima, A. (2013). Medicinal plants and their bioactive compounds. Journal of Medicinal Plants Research, 7(14), 815-827.
Yusof, M. Y., & Ibrahim, M. (2016). Medicinal plants in the treatment of infectious diseases: Research. Phytotherapy Research, 30(3), 347-356.
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Copyright (c) 2024 Farwa Saeed, Khitab Ur Rahman, Ayisha Bibi, Rida Iqbal, Mah Noor Ayaz, Kainat Awan
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