Exploring the Role of Gut Microbiota in the Success of Physical Rehabilitation: A Longitudinal Observational Study
DOI:
https://doi.org/10.61919/jhrr.v3i1.26Keywords:
Gut microbiota, Physical Rehabilitation, Alpha Diversity, Functional Independence Measure, Western Ontario And Mcmaster Universities Arthritis IndexAbstract
BACKGROUND: The gut microbiota plays a pivotal role in human health and may potentially influence the outcomes in various medical interventions. However, its role in physical rehabilitation has been relatively unexplored.
OBJECTIVE: This study aimed to investigate the potential association between gut microbiota diversity and the success of physical rehabilitation.
METHODS: A longitudinal observational study was conducted with 150 adults undergoing physical rehabilitation. Changes in gut microbiota and rehabilitation outcomes were monitored over a 24-week period. Gut microbiota diversity was measured using alpha diversity, while rehabilitation outcomes were assessed using the Functional Independence Measure (FIM) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC).
RESULTS: The study revealed a significant increase in gut microbiota alpha diversity from a mean of 25.3 (SD=4.6) at baseline to 30.8 (SD=5.8) at 24 weeks (p<0.05). Concurrently, there was a significant improvement in the FIM scores from 85.7 (SD=12.5) to 99.6 (SD=15.1) and a decrease in WOMAC scores from 32.5 (SD=8.2) to 18.4 (SD=6.6) at 24 weeks (both p<0.01). Greater increases in gut microbiota diversity were associated with larger improvements in FIM scores (Spearman’s rho=0.56) and larger reductions in WOMAC scores (Spearman’s rho=-0.52).
CONCLUSION: The findings suggest a potential influence of gut microbiota diversity on the success of physical rehabilitation. Future research should explore the mechanisms behind these associations and the potential of microbiota-targeted interventions to enhance rehabilitation outcomes.
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Copyright (c) 2023 Dr Sana Suhail, Dr Ammara Basit, Dr Jawad Ul Hassan
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