Oral Submucous Fibrosis: A Review on Different Treatment Modalities

Main Article Content

Safia Khatoon
Prof Zubair Ahmed Abbasi
Muhammad Ilyas
Prof Dr. Huma Shareef
Prof Dr. Muhammad Khalil Khan
Sarang Suresh


Background: Oral Submucous Fibrosis (OSMF) is a chronic, debilitating condition affecting the oral mucosa, leading to significant functional impairment. It is primarily induced by the chronic use of areca nut and its commercial products. The disease is characterized by juxta-epithelial inflammation and progressive fibrosis of the submucosal tissues, resulting in severe trismus, pain, and burning sensation in the mouth.

Objective: This review aims to systematically assess and synthesize the available literature on the various treatment modalities for OSMF, evaluate their effectiveness, and identify areas requiring further research.

Methods: A comprehensive search was conducted across multiple databases including PubMed, Scopus, Web of Science, and Google Scholar using keywords such as "Oral Submucous Fibrosis," "OSMF treatment," and "fibrosis management." Studies published in English without any restriction on publication date were included. The review process involved screening titles and abstracts, followed by a full-text review. The quality and relevance of studies were assessed, focusing on study design, sample size, methodological rigor, and impact on clinical practice. Quantitative data were extracted and synthesized where available.

Results: The search yielded a total of 150 studies, of which 45 met the inclusion criteria and were analyzed. Treatment modalities varied widely, including pharmacological interventions (corticosteroids, hyaluronidase, placental extracts), physical therapies (EZbite, acrylic splints, hyperbaric oxygen therapy), surgical techniques (fibrotomy, various flap reconstructions), and emerging therapies (stem cell treatment, omega-3 supplementation). Surgical interventions showed a success rate of 60-70% in improving mouth opening, while pharmacological treatments reported a 50-60% reduction in symptoms such as burning sensation and pain. The use of stem cells and omega-3 showed promising preliminary results but lacked extensive clinical trials.

Conclusion: The treatment of OSMF requires a multidisciplinary approach, combining pharmacological, physical, and surgical modalities. While current treatments show varying degrees of effectiveness, there is a need for more randomized controlled trials to establish the efficacy of emerging therapies. Future research should focus on developing less invasive and more targeted treatments to improve patient outcomes.

Article Details

How to Cite
Khatoon , S., Abbasi, P. Z. A., Ilyas, M., Shareef, P. D. H., Khan, P. D. M. K., & Suresh, S. (2023). Oral Submucous Fibrosis: A Review on Different Treatment Modalities. Journal of Health and Rehabilitation Research, 3(2), 1212–1217. https://doi.org/10.61919/jhrr.v3i2.361
Author Biographies

Safia Khatoon , Jinnah Sindh Medical University Karachi.

BDS, FCPS, CHPE, PhD Scholar, Associate Professor & PhD Scholar, Department of Oral & Maxillofacial Surgery, Sindh Institute of oral Health Sciences.

Prof Zubair Ahmed Abbasi, Jinnah Sindh Medical University Karachi.

BDS, MSc, FFD RCS, PhD Scholar, Professor & PhD Scholar, Principal & Head Department of Oral & Maxillofacial Surgery, Sindh Institute of oral Health Sciences.

Muhammad Ilyas, Dow University of Health Sciences Karachi.

BDS, FCPS, CHPE, Associate Professor, Department of Oral & Maxillofacial Surgery, Dr. Ishrat ul Ebad Khan Institute of Oral & Health Sciences.

Prof Dr. Huma Shareef, Jinnah Sindh Medical University Karachi.

B.Pharm (KU), Pharm. D (Condensed Program, KU), M.Phil (KU), Ph.D (KU), Post Doc London, UK, Head of the Department, Institute of Pharmaceutical Sciences.

Prof Dr. Muhammad Khalil Khan, Jinnah Sindh Medical University Karachi.

BDS, MPH, PhD, Head Department of Periodontology.

Sarang Suresh, Liaquat University of Medical & Health Sciences Jamshoro.



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