Dietary Carotenoids and their Multifaceted Roles in Cancer Prevention

Main Article Content

Muhammad Aftab Shafiq
Rutaba Gul


Background: Cancer remains a significant global health challenge, with dietary and lifestyle factors playing crucial roles in its incidence and prevention. Carotenoids, naturally occurring pigments found in various fruits and vegetables, have garnered attention for their potential anti-carcinogenic properties. These compounds are known for their antioxidant and anti-inflammatory effects, which contribute to their cancer-preventing capabilities.

Objective: This review aims to systematically examine the evidence regarding the role of dietary carotenoids in cancer prevention, focusing on their mechanisms of action, associated health benefits, and the implications for dietary recommendations.

Methods: A comprehensive literature search was conducted, focusing on studies that explored the relationship between dietary intake of carotenoids and cancer risk reduction. The review included peer-reviewed articles, systematic reviews, and meta-analyses published up to April 2023. Studies were selected based on predefined inclusion and exclusion criteria, with a focus on observational and intervention studies that provided clear outcomes on cancer incidence and the effects of dietary carotenoids.

Results: The evidence suggests that carotenoids such as lycopene, beta-carotene, lutein, and zeaxanthin have significant protective effects against various types of cancer, including breast, prostate, and lung cancers. These effects are attributed to the carotenoids' ability to neutralize free radicals, reduce oxidative stress, and modulate signaling pathways related to cell proliferation and apoptosis. Increased dietary intake of carotenoid-rich foods is associated with a reduced risk of cancer, highlighting the importance of diet in cancer prevention strategies.

Conclusion: Dietary carotenoids play a crucial role in cancer prevention, offering protective effects against the development of several cancer types. The findings support the inclusion of carotenoid-rich foods in dietary recommendations as a potential strategy for reducing cancer risk. Future research should focus on understanding the optimal levels of carotenoid intake and exploring the synergistic effects of carotenoids and other bioactive compounds in cancer prevention.

Article Details

How to Cite
Shafiq, M. A., Gul, R., & Nazik, G. (2024). Dietary Carotenoids and their Multifaceted Roles in Cancer Prevention. Journal of Health and Rehabilitation Research, 4(1), 863–868.


Bray F, Laversanne M, Weiderpass E, Soerjomataram I. The ever-increasing importance of cancer as a leading cause of premature death worldwide. Cancer 2021;127.

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 2021;71.

Lewandowska AM, Rudzki M, Rudzki S, Lewandowski T, Laskowska B. Environmental risk factors for cancer - review paper. Annals of Agricultural and Environmental Medicine 2019;26.

Anand P, Kunnumakkara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, et al. Cancer is a preventable disease that requires major lifestyle changes (Pharmaceutical Research DOI: 10.1007/s11095-008-9661-9). Pharm Res 2008;25:2200.

Bail J, Meneses K, Demark-Wahnefried W. Nutritional Status and Diet in Cancer Prevention. Semin Oncol Nurs 2016;32.

Andersen ID, Espersen BT. Physical activity has a positive impact on cancer patients. Sygeplejersken / Danish Journal of Nursing 2011;111.

Klaunig JE. Oxidative Stress and Cancer. Curr Pharm Des 2019;24.

Fiedor J, Burda K. Potential role of carotenoids as antioxidants in human health and disease. Nutrients 2014;6.

Tanaka T, Shnimizu M, Moriwaki H. Cancer chemoprevention by carotenoids. Molecules 2012;17.

González-Peña MA, Ortega-Regules AE, Anaya de Parrodi C, Lozada-Ramírez JD. Chemistry, Occurrence, Properties, Applications, and Encapsulation of Carotenoids—A Review. Plants 2023;12:313.

Maoka T. Carotenoids as natural functional pigments. J Nat Med 2020;74.

Jaswir I, Noviendri D, Hasrini RF, Octavianti F. Carotenoids: Sources, medicinal properties and their application in food and nutraceutical industry. J Med Plant Res 2011;5.

Koklesova L, Liskova A, Samec M, Buhrmann C, Samuel SM, Varghese E, et al. Carotenoids in cancer apoptosis—the road from bench to bedside and back. Cancers (Basel) 2020;12.

Edge R, McGarvey DJ, Truscott TG. The carotenoids as anti-oxidants - A review. J Photochem Photobiol B 1997;41.

Krinsky NI, Johnson EJ. Carotenoid actions and their relation to health and disease. Mol Aspects Med 2005;26.

Widomska J, Welc R, Gruszecki WI. The effect of carotenoids on the concentration of singlet oxygen in lipid membranes. Biochim Biophys Acta Biomembr 2019;1861.

Saini RK, Keum YS, Daglia M, Rengasamy KR. Dietary carotenoids in cancer chemoprevention and chemotherapy: A review of emerging evidence. Pharmacol Res 2020;157.

Britton G, Liaaen-Jensen S, Pfander H. Carotenoids: handbook. Birkhäuser; 2012.

Liaaen-Jensen S, Britton G, Pfander H. Carotenoids, handbook 2004.

Miller DD, Li T, Liu RH. Antioxidants and Phytochemicals. Reference Module in Biomedical Sciences, 2014.

Krubasik P, Sandmann G. A carotenogenic gene cluster from Brevibacterium linens with novel lycopene cyclase genes involved in the synthesis of aromatic carotenoids. Molecular and General Genetics 2000;263.

Caseiro M, Ascenso A, Costa A, Creagh-Flynn J, Johnson M, Simões S. Lycopene in human health. LWT 2020;127.

Maiani G, Castón MJP, Catasta G, Toti E, Cambrodón IG, Bysted A, et al. Carotenoids: Actual knowledge on food sources, intakes, stability and bioavailability and their protective role in humans. Mol Nutr Food Res 2009;53.

Aghel N, Ramezani Z, Amirfakhrian S. Isolation and quantification of lycopene from: Tomato cultivated in Dezfoul, Iran. Jundishapur J Nat Pharm Prod 2011;6.

Alda LM, Gogoa I, Bordean D, Gergen I, Alda S, Moldovan C, et al. Lycopene content of tomatoes and tomato products. Journal of Agroalimentary Process and Technologies 2009;15.

Clinton SK. Lycopene: Chemistry, biology, and implications for human health and disease. Nutr Rev 1998;56.

Hart DJ, Scott KJ. Development and evaluation of an HPLC method for the analysis of carotenoids in foods, and the measurement of the carotenoid content of vegetables and fruits commonly consumed in the UK. Food Chem 1995;54.

Story EN, Kopec RE, Schwartz SJ, Keith Harris G. An update on the health effects of tomato lycopene. Annu Rev Food Sci Technol 2010;1.

Moran NE, Erdman JW, Clinton SK. Complex interactions between dietary and genetic factors impact lycopene metabolism and distribution. Arch Biochem Biophys 2013;539.

Parada J, Aguilera JM. Food microstructure affects the bioavailability of several nutrients. J Food Sci 2007;72.

Xianquan S, Shi J, Kakuda Y, Yueming J. Stability of lycopene during food processing and storage. J Med Food 2005;8.

Arballo J, Amengual J, Erdman JW. Lycopene: A critical review of digestion, absorption, metabolism, and excretion. Antioxidants 2021;10.

Brown MJ, Ferruzzi MG, Nguyen ML, Cooper DA, Eldridge AL, Schwartz SJ, et al. Carotenoid bioavailability is higher from salads ingested with full-fat than with fat-reduced salad dressings as measured with electrochemical detection. American Journal of Clinical Nutrition 2004;80.

Rao AV, Agarwal S. Role of Antioxidant Lycopene in Cancer and Heart Disease. J Am Coll Nutr 2000;19.

Di Mascio P, Kaiser S, Sies H. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 1989;274.

Mortensen A, Skibsted LH. Relative stability of carotenoid radical cations and homologue tocopheroxyl radicals. A real time kinetic study of antioxidant hierarchy. FEBS Lett 1997;417.

Takeshima M, Ono M, Higuchi T, Chen C, Hara T, Nakano S. Anti-proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines. Cancer Sci 2014;105.

Sesso HD, Buring JE, Zhang SM, Norkus EP, Gaziano JM. Dietary and plasma lycopene and the risk of breast cancer. Cancer Epidemiology Biomarkers and Prevention 2005;14.

Ilic D, Forbes KM, Hassed C. Lycopene for the prevention of prostate cancer. Cochrane Database of Systematic Reviews 2011;2011.

Zu K, Mucci L, Rosner BA, Clinton SK, Loda M, Stampfer MJ, et al. Dietary lycopene, angiogenesis, and prostate cancer: A prospective study in the prostate-specific antigen era. J Natl Cancer Inst 2014;106.

Zhao Z, Chen J, Ci FF, Pang H, Cheng N, Xing A. α-Carotene: a valuable carotenoid in biological and medical research. J Sci Food Agric 2022.

Jian L, Du CJ, Lee AH, Binns CW. Do dietary lycopene and other carotenoids protect against prostate cancer? Int J Cancer 2005;113.

Abar L, Vieira AR, Aune D, Stevens C, Vingeliene S, Navarro Rosenblatt DA, et al. Blood concentrations of carotenoids and retinol and lung cancer risk: an update of the WCRF–AICR systematic review of published prospective studies. Cancer Med 2016;5.

Peng C, Zeleznik OA, Shutta KH, Rosner BA, Kraft P, Clish CB, et al. A Metabolomics Analysis of Circulating Carotenoids and Breast Cancer Risk. Cancer Epidemiology Biomarkers and Prevention 2022;31.

Rodriguez-Amaya DB. Structures and analysis of carotenoid molecules. Subcell Biochem 2016;79.

Wyss A, Wirtz GM, Woggon WD, Brugger R, Wyss M, Friedlein A, et al. Expression pattern and localization of β,β-carotene 15,15′-dioxygenase in different tissues. Biochemical Journal 2001;354.

Rodriguez-Amaya DB. Structures and analysis of carotenoid molecules. Subcell Biochem 2016;79.

Peng C, Gao C, Lu D, Rosner BA, Zeleznik O, Hankinson SE, et al. Circulating carotenoids and breast cancer among high-risk individuals. American Journal of Clinical Nutrition 2021;113.

Chen QH, Wu BK, Pan D, Sang LX, Chang B. Beta-carotene and its protective effect on gastric cancer. World J Clin Cases 2021;9.

Larsson SC, Bergkvist L, Näslund I, Rutegård J, Wolk A. Vitamin A, retinol, and carotenoids and the risk of gastric cancer: A prospective cohort study. American Journal of Clinical Nutrition 2007;85.

Kim Y, Seo JH, Kim H. β-Carotene and lutein inhibit hydrogen peroxide-induced activation of NF-κB and IL-8 expression in gastric epithelial AGS cells. J Nutr Sci Vitaminol (Tokyo) 2011;57.

Mayne ST, Cartmel B, Baum M, Shor-Posner G, Fallon BG, Briskin K, et al. Randomized trial of supplemental β-carotene to prevent second head and neck cancer. Cancer Res 2001;61:1457–63.

Brewczyński A, Jabłońska B, Kentnowski M, Mrowiec S, Składowski K, Rutkowski T. The association between carotenoids and head and neck cancer risk. Nutrients 2022;14.

Chen J, Jiang W, Shao L, Zhong D, Wu Y, Cai J. Association between intake of antioxidants and pancreatic cancer risk: a meta-analysis. Int J Food Sci Nutr 2016;67.

Kotake-Nara E, Nagao A. Absorption and metabolism of xanthophylls. Mar Drugs 2011;9.

Aziz E, Batool R, Akhtar W, Rehman S, Shahzad T, Malik A, et al. Xanthophyll: Health benefits and therapeutic insights. Life Sci 2020;240.

Pereira AG, Otero P, Echave J, Carreira-Casais A, Chamorro F, Collazo N, et al. Xanthophylls from the Sea: Algae as Source of Bioactive Carotenoids. Mar Drugs 2021;19.

Terasaki M. Potential ability of xanthophylls to prevent obesity-associated cancer. World J Pharmacol 2014;3.

Khan NA, Walk AM, Edwards CG, Jones AR, Cannavale CN, Thompson S V., et al. Macular xanthophylls are related to intellectual ability among adults with overweight and obesity. Nutrients 2018;10.

Bouyahya A, El Omari N, Hakkur M, El Hachlafi N, Charfi S, Balahbib A, et al. Sources, health benefits, and biological properties of zeaxanthin. Trends Food Sci Technol 2021;118.

Ojulari OV, Gi Lee S, Nam JO. Therapeutic effect of seaweed derived xanthophyl carotenoid on obesity management; overview of the last decade. Int J Mol Sci 2020;21.

Calvo MM. Lutein: A valuable ingredient of fruit and vegetables. Crit Rev Food Sci Nutr 2005;45.

Johnson EJ. A Biological Role of Lutein. Food Reviews International 2004;20.

Patel K, Patel DK. Biological Importance, Pharmacological Activities, and Nutraceutical Potential of Capsanthin: A Review of Capsicum Plant Capsaicinoids. Curr Drug Res Rev 2023;16.