Marburg Virus Disease Outbreaks – A Systematic Review

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Published: Dec 31, 2023
DOI: https://doi.org/10.61919/jhrr.v3i2.541
Keywords:
Marburg Virus Disease, Epidemiology, Outbreaks, Public Health, Case Fatality Rate, Seroprevalence, Systematic Review, Viral Haemorrhagic Fever, Global Health, Infection Control

Main Article Content

Yasir Akbar Jamali
University of Sindh Jamshoro Pakistan.
Imran Ali Jamali
Peoples University of Medical and Health Sciences For Women (PUMHSW) Nawabshah Pakistan
Ali Bux Khuhro
Shah Abdul Latif University Khairpur Pakistan.
Jeetender
Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro Pakistan.
Jawad Ahmad Khan
Shah Abdul Latif University Khairpur Pakistan
Bhanwrio Menghwar
Suleman Roshan Medical College Tando Jam Pakistan.

Abstract

Background: Marburg virus disease (MARV) is a highly virulent disease that presents a significant threat to public health. First identified in 1967, MARV has since manifested sporadically across various regions, with varying consequences. This systematic review aims to collate and analyze epidemiological data to understand the impact of MARV globally.


Objective: The primary objective of this study was to synthesize data from past outbreaks to evaluate the epidemiological characteristics of MARV, understand its transmission dynamics, and assess the effectiveness of response strategies.


Methods: We conducted a systematic search across several academic databases including MEDLINE, Google Scholar, and Web of Science, up until August 2023. Studies were included if they reported the total number of cases and fatalities during MARV outbreaks. The meta-analysis focused on case fatality rates (CFRs) and seroprevalence measurements. Data from health ministries, the World Health Organization, and the Centers for Disease Control and Prevention were used to verify the findings.


Results: The review identified 16 studies for inclusion. The reported case fatality rates varied significantly across different outbreaks, with Angola (2006) reporting the highest number of cases (252) and deaths (227). The recent outbreak in Ghana (2023) indicated an uptick in both case numbers (40) and CFR (87.3%). The containment of an outbreak in Equatorial Guinea by June 2023 highlights the effectiveness of international cooperation and robust health systems.


Conclusion: The study concludes that the Marburg virus remains a critical concern for global health, particularly in regions with previous outbreaks. The data underscore the necessity for improved public health preparedness and response strategies in high-risk areas to mitigate future outbreaks.

Article Details

How to Cite
Jamali, Y. A., Jamali, I. A., Khuhro, A. B., Jeetender, Khan, J. A., & Menghwar, B. (2023). Marburg Virus Disease Outbreaks – A Systematic Review. Journal of Health and Rehabilitation Research, 3(2), 1305–1310. https://doi.org/10.61919/jhrr.v3i2.541
Issue
Vol. 3 No. 2 (2023): Volume 3, Issue 2 - July to December 2023
Section
Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Author Biographies

Yasir Akbar Jamali, University of Sindh Jamshoro Pakistan.

Department of Physiology.

Imran Ali Jamali, Peoples University of Medical and Health Sciences For Women (PUMHSW) Nawabshah Pakistan

Department of Community Medicine.

Ali Bux Khuhro, Shah Abdul Latif University Khairpur Pakistan.

Institute of Microbiology.

Jeetender, Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro Pakistan.

Institute of Physiotherapy and Rehabilitation Science.

Jawad Ahmad Khan, Shah Abdul Latif University Khairpur Pakistan

Department of Pharmacy

Bhanwrio Menghwar, Suleman Roshan Medical College Tando Jam Pakistan.

Department of Physiology.

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