Serum Ferritin Level and Total Iron Binding Capacity Relationship with Iron Deficiency Anemia During Pregnancy and Labour

Main Article Content

Majida Ali
Ishfaque Ahmed Mugheri
Noshaba Nafees Abro
Saeed Un Nisa Sangi
Afshan Tariq Bhatti
Shazia Shiakh

Abstract

Background: Iron deficiency anemia (IDA) is a prevalent condition globally, impacting maternal and fetal health outcomes significantly. The condition is especially concerning during pregnancy, given its association with complications such as preterm labor and increased maternal and neonatal morbidity and mortality rates.


Objective: The study aimed to assess the prevalence of IDA among pregnant women and its correlation with fetal-maternal complications, as well as to evaluate the effectiveness of current healthcare interventions in managing the condition.


Methods: A cross-sectional study was conducted at Shikhzayad Women Hospital, Larkana, over six months from January 1, 2022, to July 1, 2022. Fifty pregnant women with IDA at various gestational stages were selected and evaluated for serum ferritin and total iron-binding capacity (TIBC). The severity of anemia and its correlation with feto-maternal complications were analyzed using SPSS version 25.


Results: Out of the 50 women studied, 6 had mild anemia, 37 had moderate anemia, and 7 had severe anemia. Serum ferritin levels showed that 10 participants had levels between 5-10 mg/L, 20 had levels between 10-50 mg/L, 10 had levels between 50-150 mg/L, and 10 had normal levels (150-300 mg/L). Elevated TIBC levels (400-600 ug/ml) were observed in 30 women. Feto-maternal complications included emergency cesarean sections (28 cases), postpartum hemorrhage (8 cases), disseminated intravascular coagulation (6 cases), cardiac failure (4 cases), and maternal death (4 cases). Pregnancy outcomes were reported as 5 first-trimester abortions, 2 second-trimester abortions, 4 preterm deliveries, 15 cases of intrauterine growth restriction (IUGR), 9 intrauterine deaths (IUD), and 5 neonatal deaths (NND).


Conclusion: IDA remains a significant determinant of adverse maternal and neonatal outcomes. This study underscores the urgent need for enhanced preventive strategies, including iron supplementation and dietary education. Further large-scale research is required for a comprehensive understanding of IDA's impact and the development of targeted interventions.

Article Details

How to Cite
Ali, M., Mugheri, I. A., Abro, N. N., Sangi, S. U. N., Bhatti, A. T., & Shiakh, S. (2024). Serum Ferritin Level and Total Iron Binding Capacity Relationship with Iron Deficiency Anemia During Pregnancy and Labour. Journal of Health and Rehabilitation Research, 4(1), 1234–1238. https://doi.org/10.61919/jhrr.v4i1.622
Section
Articles
Author Biographies

Majida Ali, Shaikh Zayed Women Hospital CMC Larkana Pakistan.

Department of Gyn/Obs, Shaikh Zayed Women Hospital, CMC Larkana, Pakistan.

Ishfaque Ahmed Mugheri, University of Sindh Jamshoro Pakistan.

Institute of Biochemistry, University of Sindh Jamshoro, Pakistan.

Noshaba Nafees Abro, Shaikh Zayed Women Hospital CMC Larkana Pakistan.

Department of Gyn/Obs, Shaikh Zayed Women Hospital, CMC Larkana, Pakistan.

Saeed Un Nisa Sangi, Shaikh Zayed Women Hospital CMC Larkana

Department of Gyn/Obs, Shaikh Zayed Women Hospital, CMC Larkana Pakistan.

Afshan Tariq Bhatti, Shaikh Zayed Women Hospital CMC Larkana Pakistan.

Department of Gyn/Obs, Shaikh Zayed Women Hospital, CMC Larkana, Pakistan.

Shazia Shiakh, Shaikh Zayed Women Hospital CMC Larkana Pakistan.

Department of Gyn/Obs, Shaikh Zayed Women Hospital, CMC Larkana, Pakistan.

References

Chang M-L, Hu J-H, Yen C-H, Chen K-H, Kuo C-J, Lin M-S, et al. Evolution of ferritin levels in hepatitis C patients treated with antivirals. Scientific reports. 2020;10(1):19744.

Chen Y, Wan J, Xia H, Li Y, Xu Y, Lin H, et al. Total iron binding capacity (TIBC) is a potential biomarker of left ventricular remodelling for patients with iron deficiency anaemia. BMC cardiovascular disorders. 2020;20:1-9.

DePalma RG, Hayes VW, O'Leary TJ. Optimal serum ferritin level range: Iron status measure and inflammatory biomarker. Metallomics. 2021;13(6):mfab030.

Faruqi A, Mukkamalla SKR. Iron binding capacity. 2020.

Freeman HJ. Iron deficiency anemia in celiac disease. World Journal of Gastroenterology: WJG. 2015;21(31):9233.

Galetti V, Stoffel NU, Sieber C, Zeder C, Moretti D, Zimmermann MB. Threshold ferritin and hepcidin concentrations indicating early iron deficiency in young women based on upregulation of iron absorption. EClinicalMedicine. 2021;39.

Grant ES, Clucas DB, McColl G, Hall LT, Simpson DA. Re-examining ferritin-bound iron: current and developing clinical tools. Clinical Chemistry and Laboratory Medicine (CCLM). 2021;59(3):459-71.

Hasan HR, Kadhum ZIA, Ghadhban JM. Biochemical Markers of Iron Status Among Iraqi Patients at Different Severity Levels of Celiac Disease. Iraqi Journal of Science. 2024.

Ikeda-Taniguchi M, Takahashi K, Shishido K, Honda H. Total iron binding capacity is a predictor for muscle loss in maintenance hemodialysis patients. Clinical and Experimental Nephrology. 2022;26(6):583-92.

Jimenez K, Kulnigg-Dabsch S, Gasche C. Management of iron deficiency anemia. Gastroenterology & hepatology. 2015;11(4):241.

Kishore G, Ejaz M, Kumar J, Lal A, Tahir H, Anjum Z, et al. Association between Helicobacter pylori infection and serum iron profile. Cureus. 2021;13(9).

Lu M, Liu Y, Shao M, Tesfaye GC, Yang S. Associations of iron intake, serum iron and serum ferritin with bone mineral density in women: the National Health and Nutrition Examination Survey, 2005–2010. Calcified Tissue International. 2020;106:232-8.

Means RT. Iron deficiency and iron deficiency anemia: implications and impact in pregnancy, fetal development, and early childhood parameters. Nutrients. 2020;12(2):447.

Miller JL. Iron deficiency anemia: a common and curable disease. Cold Spring Harbor perspectives in medicine. 2013;3(7):a011866.

Organization WH. WHO guideline on use of ferritin concentrations to assess iron status in populations: World Health Organization; 2020.

Pavord S, Myers B, Robinson S, Allard S, Strong J, Oppenheimer C, et al. UK guidelines on the management of iron deficiency in pregnancy. British journal of haematology. 2012;156(5):588-600.

Rahat A, Kamani L. Frequency of iron deficiency anemia (IDA) among patients with Helicobacter pylori infection. Pakistan Journal of Medical Sciences. 2021;37(3):776.

Ribot-Hernández I, Martín-González C, Vera-Delgado V, González-Navarrete L, de Armas-González JF, Viña-Rodríguez J, et al. Prognostic value of serum iron, ferritin, and transferrin in chronic alcoholic liver disease. Biological trace element research. 2020;195:427-35.

Sab PC, Kaur G, Kaur P, Tahlan A, Bedi RK, Mittal K, et al. Assessment of serum iron stores in regular plateletpheresis donors. Transfusion and Apheresis Science. 2022;61(1):103291.

Sifakis S, Pharmakides G. Anemia in pregnancy. Annals of the New York Academy of Sciences. 2000;900(1):125-36.

Tandon R, Jain A, Malhotra P. Management of iron deficiency anemia in pregnancy in India. Indian Journal of Hematology and Blood Transfusion. 2018;34:204-15.

Wang Y, Yang Z, Wu J, Xie D, Yang T, Li H, et al. Associations of serum iron and ferritin with hyperuricemia and serum uric acid. Clinical Rheumatology. 2020;39:3777-85.

Most read articles by the same author(s)

Similar Articles

You may also start an advanced similarity search for this article.