Effect of Antiviral Drug on Viral Load Patients Infected with Hepatitis C Virus Genotype 3

Main Article Content

Waheed Ali
Om Parkash
Shamim Bhatti
Faiqa Waheed


Background: Hepatitis C Virus (HCV) genotype 3 is recognized for its rapid progression towards liver fibrosis, cirrhosis, and increased risk of hepatocellular carcinoma, particularly in regions with high prevalence rates like Pakistan. Despite advances in treatment, understanding the efficacy and outcomes of direct-acting antiviral (DAA) therapy in this specific genotype remains crucial for optimizing clinical management and public health strategies.

Objective: This study aims to evaluate the efficacy and safety of daclatasvir and sofosbuvir combination therapy in patients with HCV genotype 3 infection, focusing on sustained virologic response (SVR), viral load reduction, and treatment-related adverse events.

Methods: A single-group, pretest-posttest design was utilized, involving 130 participants diagnosed with HCV genotype 3. Patients received a 12-week regimen of daclatasvir (60mg daily) and sofosbuvir (400mg daily). The study conducted thorough pre-treatment and post-treatment assessments, including ELISA for HCV antibodies, PCR for viral load determination, and genotyping. Statistical analyses were performed using SPSS version 25, with significance set at p<0.05.

Results: Of the 130 participants, 93% achieved SVR at 12 weeks post-treatment. The pre-treatment viral load ranged from 78,200 to 120,900,000 IU/mL, significantly decreasing post-treatment across the cohort. Genotype analysis confirmed HCV genotype 3 in 85.71% of cases. Treatment was well-tolerated, with no serious adverse events reported.

Conclusion: The combination therapy of daclatasvir and sofosbuvir was highly effective and safe in treating patients with HCV genotype 3 infection, demonstrating a high rate of SVR and a significant reduction in viral load without severe adverse events. These findings support the use of this regimen as a viable treatment option for this challenging HCV genotype.

Article Details

How to Cite
Ali, W., Parkash, O., Bhatti, S., & Waheed, F. (2024). Effect of Antiviral Drug on Viral Load Patients Infected with Hepatitis C Virus Genotype 3. Journal of Health and Rehabilitation Research, 4(1), 1542–1546. https://doi.org/10.61919/jhrr.v4i1.635
Author Biographies

Waheed Ali, Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences (PAQSJ) Gambat Pakistan

Department of Microbiology Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences (PAQSJ) Gambat Pakistan

Om Parkash, Chandka Medical College (CMC) Larkana Pakistan

HOD Department of Pathology, Chandka Medical College (CMC) Larkana Pakistan

Shamim Bhatti, Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences (PAQSJ) Gambat Pakistan

Department of Pathology Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences (PAQSJ) Gambat Pakistan

Faiqa Waheed, JIMS Jacobabad Hospital Pakistan  

Department of Microbiology JIMS Jacobabad Hospital Pakistan


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