Frequency and Distribution of Complications in Cholesteatoma Patients: A Tertiary Care Hospital Study

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Noshad Ali
Saqib Aziz
Hurtamina Khan
Unsa Iqbal
Sameer Qureshi
Ramsha Shahab


Background: Cholesteatoma, a benign epithelial lesion, progresses with time, necessitating surgical intervention. The most common surgical treatments are canal wall up (CWU) and canal wall down (CWD). CWU, though preserving ear canal anatomy, has a higher risk of recurrence, prompting a need to evaluate the frequency and nature of complications arising from cholesteatoma to improve treatment outcomes.

Objective: This study aims to identify the frequency and types of complications in patients diagnosed with cholesteatoma at a tertiary care hospital.

Methods: Conducted as a cross-sectional analysis at the Department of ENT, Jinnah Postgraduate Medical Centre, Karachi, from August 10, 2019, to February 9, 2020, this study included 210 diagnosed patients. Through otoscopy, audiologic evaluations, and microscope examinations for selected cases, patients with signs of persistent disease underwent mastoid exploration. Surgical interventions were tailored based on disease extent and type. Statistical analysis employed descriptive statistics, stratification, and Chi-square tests for significance (P-value ≤0.05).

Results: Of the participants, 57.6% were male, and 42.4% were female, with an average age of 31.30±8.75 years and a mean disease duration of 8.73±3.63 months. Extracranial complications were identified in 29% of patients, with 12.4% experiencing ossicular damage. Intracranial complications were found in 18.1% of patients, with meningitis constituting 8.6% of these cases. A total of 5.7% presented with multiple complications. No significant associations were found between the complications and variables such as gender, age, BMI, and disease duration.

Conclusion: Extracranial complications, notably ossicular damage, were most common, followed by intracranial complications and multiple complications, underlining the necessity for early diagnosis and targeted treatment strategies.

Article Details

How to Cite
Ali, N., Aziz , S., Khan, H., Iqbal, U., Qureshi, S., & Shahab, R. (2024). Frequency and Distribution of Complications in Cholesteatoma Patients: A Tertiary Care Hospital Study. Journal of Health and Rehabilitation Research, 4(1), 1248–1255.
Author Biographies

Noshad Ali, Jinnah Postgraduate Medical Centre Karachi

Postgraduate Trainee, Department of ENT, Jinnah Postgraduate Medical Centre Karachi

Saqib Aziz , Shaukat Khanum Hospital Lahore.

Fellow Head and Neck Surgical Oncology, Shaukat Khanum Hospital, Lahore.

Hurtamina Khan, Jinnah Postgraduate Medical Centre Karachi

Assistant Professor, Department of ENT, Jinnah Postgraduate Medical Centre Karachi

Unsa Iqbal, Jinnah Medical and Dental College (Sohail Trust Hospital)

Registrar, Department of ENT, Jinnah Medical and Dental College (Sohail Trust Hospital)

Sameer Qureshi, Naimat Begum Hamdard University Hospital Karachi

Professor, ENT Department, Naimat Begum Hamdard University Hospital Karachi

Ramsha Shahab, Inspire Pakistan Institute Karachi

Medical Officer, Inspire Pakistan Institute Karachi


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