Clinical Profile and Risk Factors of Cerebral Venous Sinus Thrombosis

Main Article Content

Huma Khan
Khalid Sher
Khawaja Moiz Ullah Ghouri

Abstract

Background: Cerebral venous sinus thrombosis (CVST) is a rare but serious neurovascular disorder that can lead to life-threatening complications such as hemorrhage and cerebral edema. This condition presents with a wide array of symptoms due to the formation of blood clots in the cerebral venous sinuses, impairing the drainage of deoxygenated blood and cerebrospinal fluid from the brain.


Objective: The aim of this study was to elucidate the clinical profile and risk factors associated with CVST, enhancing the understanding of its epidemiology and facilitating better diagnostic and therapeutic strategies.


Methods: This prospective cross-sectional study was conducted at the Department of Neurology, Jinnah Postgraduate Medical Centre, Karachi, Pakistan. A total of 135 participants diagnosed with CVST were enrolled through non-probability consecutive sampling. Participants underwent comprehensive physical and neurological examinations using a structured Clinical Patient Assessment Form. Diagnostic imaging included MRI, MRV, CT, and CT venography, although the principal diagnostic tools were CT and MRV. Data collection focused on demographics, clinical manifestations, and risk factors, with all information analyzed using SPSS version 25.


Results: The study population predominantly consisted of females (74.8%) with the age group of 31-40 years being the most common (31.1%). Headache was the most frequently reported symptom (90.4%), followed by hemiparesis (53.3%) and seizures (40%). Significant risk factors included postpartum status (50.4%), iron deficiency anemia (25.9%), and genetic prothrombotic conditions (9.6%). Imaging studies revealed that the transverse sinus was the most affected site (74.1%).


Conclusion: CVST exhibits a diverse range of clinical presentations and is associated with multiple demographic and physiological risk factors. Early diagnosis and management are crucial to prevent severe outcomes. This study highlights the importance of considering a detailed clinical and risk factor profile in patients presenting with neurological symptoms to aid in timely and accurate diagnosis of CVST.

Article Details

How to Cite
Khan, H., Sher, K., & Ghouri, K. M. U. (2024). Clinical Profile and Risk Factors of Cerebral Venous Sinus Thrombosis. Journal of Health and Rehabilitation Research, 4(2), 548–552. https://doi.org/10.61919/jhrr.v4i2.865
Section
Articles
Author Biographies

Huma Khan, Jinnah Postgraduate Medical Center (JPMC) Karachi Pakistan.

Jinnah Postgraduate Medical Center (JPMC), Karachi, Pakistan.

Khalid Sher, Jinnah Postgraduate Medical Center (JPMC) Karachi Pakistan.

Jinnah Postgraduate Medical Center (JPMC), Karachi, Pakistan.

Khawaja Moiz Ullah Ghouri, University of Karachi Pakistan.

Department of Statistics, University of Karachi, Pakistan.

References

Bai C, Wang Z, Stone C, Zhou D, Ding J, Ding Y, et al. Pathogenesis and Management in Cerebrovenous Outflow Disorders. Aging Dis. 2021;12(1):203.

Ferro JM, Canhão P, Stam J, Bousser MG, Barinagarrementeria F. Prognosis of Cerebral Vein and Dural Sinus Thrombosis: Results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke. 2004;35(3):664-70.

Bousser MG, Ferro JM. Cerebral Venous Thrombosis: An Update. Lancet Neurol. 2007;6(2):162-70.

Saadatnia M, Fatehi F, Basiri K, Mousavi SA, Mehr GK. Cerebral Venous Sinus Thrombosis Risk Factors. Int J Stroke. 2009;4(2):111-23.

Ferro JM, Canhão P. Cerebral Venous Sinus Thrombosis: Update on Diagnosis and Management. Curr Cardiol Rep. 2014;16:1-0.

Allroggen H, Abbott RJ. Cerebral Venous Sinus Thrombosis. Postgrad Med J. 2000;76(891):12-5.

Filippidis A, Kapsalaki E, Patramani G, Fountas KN. Cerebral Venous Sinus Thrombosis: Review of the Demographics, Pathophysiology, Current Diagnosis, and Treatment. Neurosurg Focus. 2009;27(5):E3.

Fischer C, Goldstein J, Edlow J. Cerebral Venous Sinus Thrombosis in the Emergency Department: Retrospective Analysis of 17 Cases and Review of the Literature. J Emerg Med. 2010;38(2):140-7.

Bousser MG, Crassard I. Cerebral Venous Thrombosis, Pregnancy and Oral Contraceptives. Thromb Res. 2012;130:S19–22.

Coutinho JM. Cerebral Venous Thrombosis. J Thromb Haemost. 2015;13:S238-44.

Lauw MN, Barco S, Coutinho JM, Middeldorp S. Cerebral Venous Thrombosis and Thrombophilia: A Systematic Review and Meta-Analysis. Semin Thromb Hemost. 2013;39:913-27.

Tanislav C, Siekmann R, Sieweke N, Allendörfer J, Pabst W, Kaps M, et al. Cerebral Vein Thrombosis: Clinical Manifestation and Diagnosis. BMC Neurol. 2011;11:1-5.

Mehvari Habibabadi J, Saadatnia M, Tabrizi N. Seizure in Cerebral Venous and Sinus Thrombosis. Epilepsia Open. 2018;3(3):316-22.

Hemasian H, Hakamifard A. Thrombophilic Evaluation in Cases of Cerebral Venous Sinus Thrombosis. Oman Med J. 2018;33(6):537.

Issar P, Chinna S, Issar SK. Evaluation of Cerebral Venous Thrombosis by CT, MRI and MR Venography. J Assoc Physicians India. 2017;65(11):16-21.

Khealani BA, Wasay M, Saadah M, Sultana E, Mustafa S, Khan FS, et al. Cerebral Venous Thrombosis: A Descriptive Multicenter Study of Patients in Pakistan and Middle East. Stroke. 2008;39(10):2707-11.

Lal D, Gujjar AR, Ramachandiran N, Obaidi A, Kumar S, El-Tigani M, et al. Spectrum of Cerebral Venous Thrombosis in Oman. Sultan Qaboos Univ Med J. 2018;18(3):e329-37.

Ibrahim EA, Mohamed RE, Ahmed KA, Haroun MS, Abdalla YA, Omer ME, et al. Clinical Profile and Risk Factors of Cerebral Venous Sinus Thrombosis (CVST) in Sudan: A Multicenter Cross-Sectional Study. Ann Med Surg. 2022;84:104891.

Narayan D, Kaul S, Ravishankar K, Suryaprabha T, Bandaru VS, Mridula KR, et al. Risk factors, clinical profile, and long-term outcome of 428 patients of cerebral sinus venous thrombosis: Insights from Nizam′ s Institute Venous Stroke Registry, Hyderabad (India). Neurol India. 2012;60(2):154-9.

Gurram S, Thambi M, Naik A, Gorthi SP. Critical Prognostic Factors in Cerebral Venous Sinus Thrombosis: An Observational Study. Annals of Indian Academy of Neurology. 2024 Jan 1;27(1):67-71.