Comparison of Duration of Action in Spinal Anesthesia of 0.5% Bupivacaine and 0.5% Bupivacaine with Dexmedetomidine
Spinal Anesthesia: Bupivacaine vs. Bupivacaine with Dexmedetomidine
DOI:
https://doi.org/10.61919/jhrr.v4i3.1459Keywords:
Spinal anesthesia, bupivacaine, dexmedetomidine, sensory block, motor block, analgesia duration, adjuncts in anesthesia, anesthesia efficacy.Abstract
Background: Spinal anesthesia is a common technique for surgeries below the navel, utilizing bupivacaine, a local anesthetic. Adding adjuncts like dexmedetomidine may enhance the efficacy and duration of the block.
Objective: To compare the duration of action of 0.5% bupivacaine versus 0.5% bupivacaine with dexmedetomidine in spinal anesthesia.
Methods: This quasi-experimental trial included 60 patients aged 20-60 years, ASA grade 1 or 2, undergoing general, plastic, orthopedic, or urological surgery at CMH Karachi. Patients were non-randomly assigned to Group B (0.5% bupivacaine, n=30) or Group BD (0.5% bupivacaine plus 5 mcg dexmedetomidine, n=30). Onset and duration of sensory and motor blocks, duration of analgesia, and adverse effects were recorded. Data were analyzed using SPSS version 25, with a p-value ≤ 0.05 considered significant.
Results: Group BD showed faster onset of sensory block (7.08 ± 0.54 mins vs. 13.48 ± 0.73 mins, p < 0.001) and motor block (10.32 ± 0.91 mins vs. 17.55 ± 0.69 mins, p < 0.001). Duration of motor block was longer in Group BD (284.06 ± 5.64 mins vs. 133.93 ± 5.72 mins, p < 0.001), as was duration of analgesia (218.07 ± 4.86 mins vs. 125.36 ± 5.42 mins, p < 0.001).
Conclusion: The addition of dexmedetomidine to 0.5% bupivacaine significantly enhances the onset and duration of spinal anesthesia with a comparable safety profile.
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Copyright (c) 2024 Muhammad Afnan Riaz, Saad Bin Qamar, Aisha Siddiqi, Sarmad Sardar, Waqas Tariq, Syed Qasim Ali Shah, Muhammad Farrukh Habib
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