Influence of Clinical and Demographic Variables 0n the Quality of Life in Patients with Cervical Cancer
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Abstract
Background: Cervical cancer remains a significant public health issue, particularly in low- and middle-income countries, where it disproportionately affects women's quality of life (QoL). Understanding the impact of clinical and demographic variables on the QoL of patients with cervical cancer is crucial for improving care and support strategies.
Objective: This study aims to assess how clinical and demographic factors influence the QoL of Pakistani women diagnosed with cervical cancer, comparing these findings against established benchmarks for both healthy individuals and those with malignancies.
Methods: Conducted at a leading cancer centre in Pakistan from April to September 2022, this cross-sectional study involved 186 women with histopathologically confirmed cervical cancer, identified through a population-based cancer database. QoL was evaluated using the Organization for Research and Treatment of Cancer QLQ-C30 (Version 3.0) questionnaire, encompassing functional scales, symptom scales, single-item scales, and a global health status score. Data analysis was performed using SPSS version 25, applying logistic regression to identify factors significantly associated with QoL outcomes.
Results: The median global health status score for enrolled patients was 50.0 [interquartile range (IQR) 33.3 - 66.7], significantly lower than the reference values for healthy females (58.0 [IQR 41.3 - 82.7]) and those with any malignancy (71.0 at age 55). Functional scale scores indicated compromised physical (65.7 [IQR 60.0 - 75.0]) and social (67.7 [IQR 56.0 - 100]) functioning. Symptom scale scores revealed high levels of pain (84.3 [IQR 65.7 - 84.3]) and fatigue (78.8 [IQR 55.7 - 88.7]). Regression analysis highlighted age and education level as significant predictors of physical health outcomes.
Conclusion: The study underscores the profound impact of cervical cancer on the QoL of Pakistani women, with age and education level emerging as key determinants. These findings call for tailored interventions to address the specific needs of this patient population, emphasizing the need for early detection and comprehensive support services.
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References
Batool SA, Sajjad S, Malik H. Cervical cancer in Pakistan: A review. JPMA The Journal of the Pakistan Medical Association. 2017;67(7):1074-7.
Arbyn M, Weiderpass E, Bruni L, de Sanjosé S, Saraiya M, Ferlay J, et al. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis. The Lancet Global Health. 2020;8(2):e191-e203.
Bjelic-Radisic V, Jensen PT, Vlasic KK, Waldenstrom A-C, Singer S, Chie W, et al. Quality of life characteristics inpatients with cervical cancer. European journal of cancer. 2012;48(16):3009-18.
Chagani P, Parpio Y, Gul R, Jabbar AA. Quality of life and its determinants in adult cancer patients undergoing chemotherapy treatment in Pakistan. Asia-Pacific journal of oncology nursing. 2017;4(2):140-6.
Nartey Y, Hill PC, Amo-Antwi K, Nyarko KM, Yarney J, Cox B. Cervical cancer in the Greater Accra and Ashanti regions of Ghana. Journal of global oncology. 2017;3(6):782-90.
Tesfaye E, Kumbi B, Mandefro B, Hemba Y, Prajapati KK, Singh SC, et al. Prevalence of human papillomavirus infection and associated factors among women attending cervical cancer screening in setting of Addis Ababa, Ethiopia. Scientific Reports. 2024;14(1):4053.
Marlow LA, Waller J, Wardle J. Barriers to cervical cancer screening among ethnic minority women: a qualitative study. Journal of Family Planning and Reproductive Health Care. 2015;41(4):248-54.
Gele AA, Qureshi SA, Kour P, Kumar B, Diaz E. Barriers and facilitators to cervical cancer screening among Pakistani and Somali immigrant women in Oslo: a qualitative study. International journal of women's health. 2017:487-96.
Dahiya N, Acharya AS, Bachani D, Sharma D, Gupta S, Haresh K, et al. Quality of life of patients with advanced cervical cancer before and after chemoradiotherapy. Asian Pacific Journal of Cancer Prevention. 2016;17(7):3095-9.
Xu B, Qian M, Zhu L, Lu Z. Study on the Relationship Between Uncertainty Tolerance and Positive Acceptance in Postoperative Patients With Cervical Cancer. Cureus. 2024;16(2).
Suzuki Y, Chen L, Ferris JS, Clair CMS, Hou JY, Khoury-Collado F, et al. Estrogen replacement therapy and non-hormonal medication use among patients with uterine cancer. Gynecologic Oncology. 2024;180:14-23.
Rahman Z, Singh U, Qureshi S, Srivastav K, Nishchal A. Assessment of quality of life in treated patients of cancer cervix. Journal of Mid-Life Health. 2017;8(4):183.
Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. JNCI: Journal of the National Cancer Institute. 1993;85(5):365-76.
Abrahão R, Brunson A, Ruddy KJ, Li Q, Li J, Ryder MM, et al. Late endocrine diseases in survivors of adolescent and young adult cancer in California: a population-based study. British Journal of Cancer. 2024:1-10.
Orji AF, Gimm G, Desai A, Parekh T. The Association of Cervical Cancer Screening With Disability Type Among US Women (Aged 25–64 Years). American Journal of Preventive Medicine. 2024;66(1):83-93.
Järvholm S, Kättström A, Kvarnström N, Dahm-Kähler P, Brännström M. Long-term health-related quality-of-life and psychosocial outcomes after uterus transplantation: a 5-year follow-up of donors and recipients. Human Reproduction. 2024;39(2):374-81.
Chanbour H, Bendfeldt GA, Chen JW, Gangavarapu LS, Younus I, Roth SG, et al. Comparison of Outcomes in Patients with Cervical Spine Metastasis After Different Surgical Approaches: A Single-Center Experience. World neurosurgery. 2024;181:e789-e800.
Servayge J, Olthof EP, Mom CH, van der Aa MA, Wenzel HH, van der Velden J, et al. Survival of Women with Advanced Stage Cervical Cancer: Neo-Adjuvant Chemotherapy Followed by Radiotherapy and Hyperthermia versus Chemoradiotherapy. Cancers. 2024;16(3):635.
Khalil J, Bellefqih S, Sahli N, Afif M, Elkacemi H, Elmajjaoui S, et al. Impact of cervical cancer on quality of life: beyond the short term (Results from a single institution) Quality of life in long-term cervical cancer survivors: results from a single institution. Gynecologic oncology research and practice. 2015;2:1-6.
Prasongvej P, Nanthakomon T, Jaisin K, Chanthasenanont A, Lertvutivivat S, Tanprasertkul C, et al. Quality of life in cervical cancer survivors and healthy women: Thai urban population study. Asian Pacific journal of cancer prevention: APJCP. 2017;18(2):385.
Abujaradeh H, Mazanec SR, Sereika SM, Connolly MC, Bender CM, Gordon B-B, et al. Economic Hardship and Associated Factors of Women With Early-Stage Breast Cancer Prior to Chemotherapy Initiation. Clinical breast cancer. 2024;24(1):36-44.