Role of Stress in Onset of Polycystic Ovarian Syndrome (PCOS)

Main Article Content

Kishwar Altaf
Kinza Mehreen
Bushra Khatoon
Mahnoor Tariq

Abstract

Background: Polycystic ovarian syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age, characterized by a variety of symptoms that impact their physical and psychological health. Recent studies have suggested a potential link between stress and the onset of PCOS, but this relationship remains underexplored.


Objective: The objective of this study was to investigate the correlation between stress and the development of PCOS in a young female population, specifically focusing on university students.


Methods: This cross-sectional study involved 105 female university students aged between 15 and 25 years from major universities in Rawalpindi and Islamabad. Participants were divided into two groups: those diagnosed with PCOS and those without. Stress levels were measured using the Perceived Stress Scale (PSS), a 10-item questionnaire scored on a 5-point Likert scale. Data were analyzed using t-test and regression analysis to explore the correlation between stress levels and the presence of PCOS.


Results: The study found that women with PCOS had significantly higher stress levels (M = 22.93, SD = 6.46) compared to those without PCOS (M = 19.56, SD = 4.45), with a t-value of 3.07 (p = .003). Regression analysis showed a positive correlation (r = .60, p < .001) between stress and PCOS. The majority of the PCOS-diagnosed group were single and within the 15-20 age range.


Conclusion: The findings indicate a significant association between high stress levels and the presence of PCOS in young women. This suggests the need for incorporating stress management strategies in the prevention and treatment of PCOS. Further research with a more diverse and larger population is recommended to generalize these findings.

Article Details

How to Cite
Altaf, K., Mehreen, K., Khatoon, B., & Tariq, M. (2023). Role of Stress in Onset of Polycystic Ovarian Syndrome (PCOS). Journal of Health and Rehabilitation Research, 3(2), 1122–1127. https://doi.org/10.61919/jhrr.v3i2.276
Section
Articles

References

Alamri AS, Alhomrani M, Alsanie WF, Almuqbil M, Alqarni KM, Alshehri SM, et al. Role of polycystic ovarian syndrome in developing psychological burden in Saudi Arabian females: A case control study. Frontiers in Public Health. 2022;10:999813.

Gnawali A, Patel V, Cuello-Ramírez A, Noor A, Rashid MY, Henin S, et al. Why are women with polycystic ovary syndrome at increased risk of depression? exploring the etiological maze. Cureus. 2021;13(2).

Kim J, Whitcomb BW, Kwan B, Zava D, Sluss PM, Dietz A, et al. Psychosocial stress and ovarian function in adolescent and young adult cancer survivors. Human Reproduction. 2021;36(2):405-14.

Dybciak P, Humeniuk E, Raczkiewicz D, Krakowiak J, Wdowiak A, Bojar I. Anxiety and depression in women with polycystic ovary syndrome. Medicina. 2022;58(7):942.

Simon V, Peigné M, Dewailly D. The Psychosocial Impact of Polycystic Ovary Syndrome. Reproductive Medicine. 2023;4(1):57-64.

Benjamin JJ, MaheshKumar K, Radha V, Rajamani K, Puttaswamy N, Koshy T, et al. Stress and polycystic ovarian syndrome-a case control study among Indian women. Clinical Epidemiology and Global Health. 2023;22:101326.

Rempert AN, Sarria I, Standeven LR, Nylander E, Segars J, Singh B. A Systematic Review of the Psychosocial Impact of Polycystic Ovarian Syndrome Before and After Treatment. Reproductive Sciences. 2023:1-26.

Khafagy G, El Sayed I, Abbas S, Soliman S. Perceived stress scale among adolescents with polycystic ovary syndrome. International journal of women's health. 2020:1253-8.

Phimphasone-Brady P, Palmer B, Vela A, Johnson RL, Harnke B, Hoffecker L, et al. Psychosocial interventions for women with polycystic ovary syndrome: a systematic review of randomized controlled trials. F&S Reviews. 2022;3(1):42-56.

Barber TM, Franks S. Obesity and polycystic ovary syndrome. Clinical endocrinology. 2021;95(4):531-41.

Louwers YV, Laven JS. Characteristics of polycystic ovary syndrome throughout life. Therapeutic Advances in Reproductive Health. 2020;14:2633494120911038.

Hajam YA, Kumar R, Thakur D, Rai S. Polycystic ovarian syndrome (PCOS): Signs, symptoms, epidemiology, environmental stress, management strategies and current therapies. Herbal Medicine Applications for Polycystic Ovarian Syndrome: CRC Press; 2023. p. 1-17.

Siddiqui S, Mateen S, Ahmad R, Moin S. A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS). Journal of Assisted Reproduction and Genetics. 2022;39(11):2439-73.

Zeber-Lubecka N, Ciebiera M, Hennig EE. Polycystic Ovary Syndrome and Oxidative Stress—From Bench to Bedside. International journal of molecular sciences. 2023;24(18):14126.

Shan H, Luo R, Guo X, Li R, Ye Z, Peng T, et al. Abnormal endometrial receptivity and oxidative stress in polycystic ovary syndrome. Frontiers in Pharmacology. 2022;13:904942.

Duică F, Dănilă CA, Boboc AE, Antoniadis P, Condrat CE, Onciul S, et al. Impact of increased oxidative stress on cardiovascular diseases in women with polycystic ovary syndrome. Frontiers in Endocrinology. 2021;12:614679.

Koike H, Harada M, Kusamoto A, Xu Z, Tanaka T, Sakaguchi N, et al. Roles of endoplasmic reticulum stress in the pathophysiology of polycystic ovary syndrome. Frontiers in endocrinology. 2023;14:1124405.

Chan SF, La Greca AM. Perceived stress scale (PSS). Encyclopedia of behavioral medicine: Springer; 2020. p. 1646-8.

Chang S, Dunaif A. Diagnosis of polycystic ovary syndrome: which criteria to use and when? Endocrinology and Metabolism Clinics. 2021;50(1):11-23.

Ribeiro Santiago PH, Nielsen T, Smithers LG, Roberts R, Jamieson L. Measuring stress in Australia: validation of the perceived stress scale (PSS-14) in a national sample. Health and Quality of Life Outcomes. 2020;18(1):1-16.

Cohen S, McKay G. Social support, stress and the buffering hypothesis: A theoretical analysis. Handbook of psychology and health, Volume IV: Routledge; 2020. p. 253-67.

Cooney LG, Dokras A. Cardiometabolic risk in polycystic ovary syndrome: current guidelines. Endocrinology and Metabolism Clinics. 2021;50(1):83-95.

Barry JA. Exploration of biological causes of psychological problems in polycystic ovary syndrome (PCOS): City University London; 2011.

Zehravi M, Maqbool M, Ara I. Depression and anxiety in women with polycystic ovarian syndrome: a literature survey. International Journal of Adolescent Medicine and Health. 2021;33(6):367-73.

Khan MJ, Ullah A, Basit S. Genetic basis of polycystic ovary syndrome (PCOS): current perspectives. The application of clinical genetics. 2019:249-60.