From Obesity to Diabetes: Uncovering Molecular Connections Sketching Proteomics, A Narrative Review

Main Article Content

Mairaj Noor
Zikhatu Amina Alleza
Muhammad Bilal Gohar
Tayyaba Irshad
Israr Aziz


Background: Recent research has illuminated the pivotal role of low-grade inflammation in metabolic diseases such as obesity and diabetes, with gut microbiota dysbiosis playing a key role. Metaproteomics offers a novel lens to explore these interactions by profiling protein compositions in microbial communities, revealing insights into the metabolic disruptions that accompany these conditions.

Objective: This study aims to compile and analyze existing metaproteomic research related to obesity and both types of diabetes, identifying specific metaproteomic alterations that correlate with these metabolic diseases.

Methods: Adhering to PRISMA guidelines, a rigorous selection process was employed to gather relevant studies on the metaproteomics of obesity and diabetes. This involved analyzing microbial and human protein alterations, focusing on patterns consistently observed in these diseases.

Results: Analysis identified unique metaproteomic signatures associated with obesity and diabetes, highlighting both microbial and human proteins. Specifically, alterations in proteins involved in carbohydrate metabolism and inflammation were recurrent. Despite the identification of up- or down-regulated proteins across studies, the limited breadth of comprehensive metaproteomic data restricts definitive conclusions.

Conclusion: Metaproteomics has shed light on the intricate metabolic disturbances in obesity and diabetes. However, the discipline remains nascent, necessitating further development of specialized databases and standardized methodologies to deepen our understanding and treatment of these complex diseases.

Article Details

How to Cite
Noor, M., Alleza, Z. A., Gohar, M. B., Irshad, T., & Aziz , I. (2024). From Obesity to Diabetes: Uncovering Molecular Connections Sketching Proteomics, A Narrative Review. Journal of Health and Rehabilitation Research, 4(2), 9–15.
Author Biographies

Mairaj Noor, Arid Agriculture University Rawalpindi Pakistan.

B.Sc. (Hons.) Human Nutrition and Dietetics, M.Sc. (Hons.) Human Nutrition and Dietetics, Department of Human Nutrition And Dietetics Arid Agriculture University Rawalpindi Pakistan.

Zikhatu Amina Alleza, Arid Agriculture University Rawalpindi Pakistan.

B.Sc. (Hons.) Human Nutrition and Dietetics, M.Sc. (Hons.) Human Nutrition and Dietetics, Department of Human Nutrition And Dietetics Arid Agriculture University Rawalpindi Pakistan.

Muhammad Bilal Gohar, Riphah International University Lahore Pakistan.

MS MLS, Department of Medical laboratory Technology Riphah International University Lahore Pakistan.

Tayyaba Irshad, COMSATS University Islamabad Pakistan.

BS MS Biosciences, Department of Biosciences COMSATS University Islamabad Pakistan.

Israr Aziz , Jeju National University South Korea.

BS MS Microbiology and Immunology PhD*, Department of Advanced Convergence Technology and Science Jeju National University South Korea.


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