Exploring the Neurogenetic Landscape of Autism Spectrum Disorder: The Role of Brain-Derived Neurotrophic Factor (BDNF) Gene in the Complex Web of Neurodevelopment

Main Article Content

Pirya Nangdev
Sameena Gul Memon
Shamshad Bano
Kahaf Naz

Abstract

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder with varied manifestations including altered metabolic profiles. Recent research highlights the potential role of Brain-Derived Neurotrophic Factor (BDNF), a hormone derived from adipose tissue, in the pathology of ASD. BDNF levels are reportedly correlated with the severity of autism symptoms, suggesting a link between metabolic dysfunction and the disorder.


Objective: This study aims to deepen the understanding of BDNF levels in individuals with ASD and to explore the implications for diagnosis, treatment, and management of the disorder. It seeks to elucidate the relationship between low BDNF levels and increased autism severity, and to identify potential therapeutic interventions targeting BDNF dysregulation.


Methods: EDTA blood samples (5ml each) from 140 participants (108 with ASD and 32 healthy controls) were collected across various hospitals in Karachi. Plasma serum levels of BDNF were analyzed following a six-month follow-up. A comprehensive statistical analysis was performed, focusing on the relationship between BDNF levels and autism severity, and evaluating diagnostic and therapeutic implications of BDNF dysregulation.


Results: Analysis revealed that lower BDNF serum levels were consistently associated with higher autism severity. Specifically, 60-70% of participants with ASD scored below 8 on the Mini-Mental State Examination (MMSE), indicating significant cognitive impairment. The statistical significance of these findings was confirmed with p-values <0.05.


Conclusion: The study confirms that low BDNF levels are significantly associated with greater severity of autism symptoms, underscoring the importance of metabolic factors in the pathogenesis of ASD. BDNF stands out as a potential biomarker for early ASD diagnosis and personalized treatment strategies. Future Prospects: Future research should aim to delineate the mechanistic relationship between BDNF dysregulation and ASD pathology. Longitudinal studies are needed to assess the long-term effects of BDNF modulation on ASD outcomes and to validate its effectiveness as both a diagnostic and prognostic marker.

Article Details

How to Cite
Nangdev, P., Memon, S. G., Bano, S., & Naz, K. (2024). Exploring the Neurogenetic Landscape of Autism Spectrum Disorder: The Role of Brain-Derived Neurotrophic Factor (BDNF) Gene in the Complex Web of Neurodevelopment. Journal of Health and Rehabilitation Research, 4(2), 233–238. https://doi.org/10.61919/jhrr.v4i2.792
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Articles
Author Biographies

Pirya Nangdev, Bilawal Medical College Liaquat University of Medical and Health Sciences LUMHS Jamshoro Sindh-Pakistan.

Lecturer, M.Phil (Anatomy), MBBS, Department of Anatomy, Bilawal Medical College Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro Sindh-Pakistan.

Sameena Gul Memon, Bilawal Medical College Liaquat University of Medical and Health Sciences LUMHS Jamshoro SindhLecturer, M.Phil (Anatomy), MBBS, Department of Anatomy, Bilawal Medical College Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro Sindh-Pakistan.

Associate Professor, MBBS, M.Phil Anatomy, Department of Anatomy, Bilawal Medical College Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro Sindh-Pakistan.

Shamshad Bano, Bilawal Medical College Liaquat University of Medical and Health Sciences LUMHS Jamshoro SindhAssociate Professor, MBBS, M.Phil Anatomy, Department of Anatomy, Bilawal Medical College Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro Sindh-Pakistan.

MBBS M.Phil Anatomy, Department of Anatomy, Bilawal Medical College Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro Sindh-Pakistan.

Kahaf Naz, Bilawal Medical College Liaquat University of Medical and Health Sciences LUMHS Jamshoro SindhMBBS M.Phil Anatomy, Department of Anatomy, Bilawal Medical College Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro Sindh-Pakistan.

MBBS, Department of Anatomy, Bilawal Medical College Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro Sindh-Pakistan.

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