Hepatoprotective Role of Aqueous Extract of Kasni Seeds in Alloxan-Induced Diabetic Mice
Hepatoprotective Effects of Kasni Seeds
DOI:
https://doi.org/10.61919/jhrr.v4i3.1173Keywords:
Kasni Seeds, Diabetic Mice, Aqueous Extract, Alloxan-Induced DiabetesAbstract
Background: Diabetes mellitus (DM) is a prevalent metabolic disorder characterized by chronic hyperglycemia, leading to various systemic complications, including liver damage. Traditional antidiabetic drugs are often associated with adverse effects, prompting interest in safer, natural alternatives like Kasni (Cichorium intybus) seeds, known for their hepatoprotective properties.
Objective: This study aimed to evaluate the hepatoprotective effects of Kasni seed aqueous extract in alloxan-induced diabetic mice.
Methods: Thirty-two male albino mice were divided into three groups: control, metformin-treated, and Kasni-treated. Diabetes was induced using alloxan monohydrate (150 mg/kg). The Kasni-treated group received 400 mg/kg of Kasni extract orally for 28 days. Blood glucose levels were monitored, and liver tissues were analyzed histologically to assess hepatocyte arrangement, central vein morphology, sinusoidal inflammation, and fatty globule presence.
Results: The Kasni-treated group showed a significant reduction in blood glucose levels (140.2 ± 8.7 mg/dL) compared to the metformin group (180.4 ± 10.5 mg/dL) (p < 0.05). Histological analysis revealed restored hepatocyte arrangement, reduced fatty globules, and normalized central vein morphology in the Kasni-treated group.
Conclusion: Kasni seed aqueous extract exhibits significant hepatoprotective effects in alloxan-induced diabetic mice, suggesting its potential as a natural therapeutic agent for managing liver complications in diabetes.
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References
Padhi S, Nayak AK, Behera A. Type II Diabetes Mellitus: A Review on Recent Drug-Based Therapeutics. Biomed Pharmacother. 2020;131:110708.
Eizirik DL, Pasquali L, Cnop M. Pancreatic β-Cells in Type 1 and Type 2 Diabetes Mellitus: Different Pathways to Failure. Nat Rev Endocrinol. 2020;16(7):349-62.
Shim K, Begum R, Yang C, Wang H. Complement Activation in Obesity, Insulin Resistance, and Type 2 Diabetes Mellitus. World J Diabetes. 2020;11(1):1-12.
Girach A, Manner D, Porta M. Diabetic Microvascular Complications: Can Patients at Risk Be Identified? A Review. Int J Clin Pract. 2006;60(11):1471-83.
Roep BO, Thomaidou S, van Tienhoven R, Zaldumbide A. Type 1 Diabetes Mellitus as a Disease of the β-Cell (Do Not Blame the Immune System?). Nat Rev Endocrinol. 2021;17(3):150-61.
Berbudi A, Rahmadika N, Tjahjadi AI, Ruslami R. Type 2 Diabetes and Its Impact on the Immune System. Curr Diabetes Rev. 2019;16(5):442-9.
Zimmet P, Alberti KGMM, Shaw J. L20 Diabetes Epidemic. Nature. 2001;414(December):782-7.
García-Ocaña P, Cobos-Palacios L, Caballero-Martínez LF. Microvascular Complications of Diabetes. Med. 2020;13(16):900-10.
Lebovitz HE. Thiazolidinediones: The Forgotten Diabetes Medications. Curr Diab Rep. 2019;19(12):151-9.
Tran N, Pham B, Le L. Bioactive Compounds in Anti-Diabetic Plants: From Herbal Medicine to Modern Drug Discovery. Biology (Basel). 2020;9(9):1-31.
Matos LC, Machado JP, Monteiro FJ, Greten HJ. Understanding Traditional Chinese Medicine Therapeutics: An Overview of the Basics and Clinical Applications. Healthc. 2021;9(3):233-42.
Babu M, Ashok K, Jula V, Mullai NK. A Review on Traditional Medicinal Plants With Anti-Diabetic Properties. Linguist Cult Rev. 2021;5(S1):1244-51.
Banday MZ, Sameer AS, Nissar S. Pathophysiology of Diabetes: An Overview. Avicenna J Med. 2020;10(4):174-88.
Matar K, Bakri O, Jazr IA, Shami S, Al-Sheikhali M, Al-Rosros H, et al. Impact of Liver Cirrhosis on the Occurrence of Diabetes Mellitus and Glucose Intolerance Among Liver Cirrhosis Patients in European Gaza Hospital: A Retroactive Study. J Gastroenterol Dig Syst. 2023;7(1):19-35.
Evelson P, Susemih I, Villarreal C, Llesuy S, Peredo H, Lemberg A, et al. Hepatic Morphological Changes and Oxidative Stress in Chronic Streptozotocin-Diabetic Rats. Oxid Med Cell Longev. 2005;4(2):147-56.
Portincasa P, Grattagliano I, Palmieri VO, Palasciano G. Nonalcoholic Steatohepatitis: Recent Advances From Experimental Models to Clinical Management. Clin Biochem. 2005;38(3):203-17.
Kume E, Fujimura H, Matsuki N, Ito M, Aruga C, Toriumi W, et al. Hepatic Changes in the Acute Phase of Streptozotocin (SZ)-Induced Diabetes in Mice. Exp Toxicol Pathol. 2004;55(6):467-80.
Dubey S, Yadav C, Bajpeyee A, Singh MP. Effect of Pleurotus Fossulatus Aqueous Extract on Biochemical Properties of Liver and Kidney in Streptozotocin-Induced Diabetic Rat. Diabetes Metab Syndr Obes. 2020;13:3035-46.
Sadeghi H, Jahanbazi F, Omidifar N, Alipoor B, Kokhdan EP, et al. Metformin Attenuates Oxidative Stress and Liver Damage After Bile Duct Ligation in Rats. Res Pharm Sci. 2019;14(2):122-9.
Amirkhani R, Farzaei MH, Ghanbari E, Khazaei M, Aneva I. Cichorium Intybus Improves Hepatic Complications Induced by Oxymetholone: An Animal Study. J Med Plants By-Products. 2022;11(1):111-8.
Butt K, Yunas S, Sheikh RM. Hepatoprotective Effect of Cichorium Intybus on Paracetamol-Induced Liver Damage in Albino Rats. Afr J Biochem Res. 2012;3(2):60-3.
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Copyright (c) 2024 Muhammad Hamza, Hassan Ali Mujhtaba, Amna Aslam, Zarish Suhail, Khalid Mehmood, Ahsan Salamat

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