Assessment of Pharmacological Effects of Methanolic Extract of Perovskia abrotanoides as Anti-Asthmatic and Hepatoprotectant Pharmacological Effects of P. abrotanoides
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Abstract
Background: Perovskia abrotanoides, a plant native to Pakistan, has traditionally been used to treat various ailments, but its pharmacological properties remain underexplored.
Objective: To evaluate the anti-asthmatic, hepatoprotective, antibacterial, and anticancer activities of the methanolic extract of Perovskia abrotanoides.
Methods: The methanolic extract was prepared via maceration and subjected to phytochemical screening. Anti-asthmatic activity was assessed using a histamine-induced bronchospasm model in guinea pigs. Hepatoprotective effects were evaluated in rabbits with CCl₄-induced hepatic damage, measuring liver function tests and conducting histopathological analysis. Antibacterial activity was tested against multiple bacterial strains using the Microplate Alamar Blue Assay, and anticancer activity was evaluated in Hela, 3T3, and MU7 cell lines.
Results: The extract significantly increased pre-convulsive time (58 ± 2.3 seconds) in guinea pigs (P < 0.05), improved liver function markers (P < 0.01), and reduced bilirubin and ALP levels. It showed 81% inhibition against Staphylococcus aureus but no significant anticancer activity.
Conclusion: The methanolic extract of Perovskia abrotanoides demonstrated significant anti-asthmatic, hepatoprotective, and antibacterial properties, with potential for therapeutic use in respiratory and liver conditions.
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