Formulation and Stability Evaluation of Topical Creams Containing Arbutin and Magnesium Ascorbyl Phosphate: Effects of Croda Wax Concentration on Physical Characteristics
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Abstract
Background: Arbutin and magnesium ascorbyl phosphate are widely recognized for their exceptional antioxidant properties, making them valuable ingredients in treating various skin disorders. These compounds are frequently incorporated into skincare products aimed at improving skin health, reducing hyperpigmentation, and providing anti-aging benefits.
Objective: The study aimed to develop and evaluate the stability of topical creams containing arbutin and magnesium ascorbyl phosphate, using varying concentrations of Croda Wax as an emulsifying agent, to determine their efficacy and suitability for dermatological applications.
Methods: Three formulations of skin lightening cream were prepared, each with different Croda Wax concentrations (2%, 2.5%, and 2.9%). The formulations underwent a water-in-oil emulsion process using a mechanical homogenizer. Physical characteristics such as color, odor, texture, and stability were assessed over 28 days. Stability was further evaluated through phase separation tests at centrifugation speeds of 4000, 4500, and 5000 rpm, and by observing changes under various temperatures and humidity conditions.
Results: All formulations exhibited stability with no phase separation. The 2% Croda Wax formulation showed the most favorable results, maintaining a white color with minimal changes over 60 days. pH values ranged from 5.85 to 6.31, indicating stability suitable for skin applications.
Conclusion: The formulated creams with arbutin and magnesium ascorbyl phosphate demonstrated excellent physical stability, making them suitable for addressing skin conditions such as hyperpigmentation and inflammation.
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