Unveiling Synergistic Bonds: Exploring Spectroscopic Interactions between Tween 20 and Bromocresol Green for Enhanced Applications
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Abstract
Background: Surfactants and dyes interact in ways that can significantly alter the optical properties of solutions, a phenomenon with broad implications across various scientific fields, including healthcare. Understanding these interactions, especially in aqueous environments, is crucial for developing advanced diagnostic tools and enhancing drug delivery systems.
Objective: This study aimed to investigate the interactions between the non-ionic surfactant Tween 20 and the dye Bromocresol Green (BCG) in aqueous solutions. By elucidating these interactions, the research sought to explore the potential for improving the accuracy and efficiency of spectroscopic assays used in medical diagnostics and therapeutic applications.
Methods: Aqueous solutions of BCG were prepared in varying concentrations of Tween 20 surfactant. Spectroscopic analyses were conducted at two wavelengths, 510 nm and 520 nm, to observe the effects of surfactant concentration on dye absorbance. The critical micelle concentration (CMC) was determined by analyzing changes in absorbance and reciprocal absorbance (1/A) patterns. Beer’s Law was applied to calculate the molar absorption coefficients, providing a quantitative measure of the interaction strength between the dye and surfactant molecules.
Results: The study found that the absorbance of BCG increased linearly with the concentration of Tween 20 up to the CMC, after which the increase continued at a different rate. At 510 nm, absorbance values ranged from 0.277 to 1.627 au as Tween 20 concentration increased from 0.005 mM to 0.017 mM, with molar absorption coefficients (ε) escalating from 0.483 to 2.839 (10^3 cm^2 mmol^-1). Similar trends were observed at 520 nm, underscoring the impact of micelle formation on dye-surfactant interactions.
Conclusion: The interaction between Tween 20 and BCG significantly affects the absorbance properties of BCG in aqueous solutions, with marked changes observed upon reaching the CMC. These findings highlight the potential of surfactant-dye interactions to enhance the performance of spectroscopic assays in healthcare settings, offering pathways to more sensitive diagnostic techniques and efficient drug delivery systems.
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References
Ghosh S, Ray A, Pramanik N. Self-assembly of surfactants: An overview on general aspects of amphiphiles. Biophysical Chemistry. 2020;265:106429.
Pandey K, Hanif M, Ameer N, Mahmood K, Abid U, Rana HL, et al. Comparison of Hydrophilic and Lipophilic Surfactants for the Improvement of Solubility of BCS Class II Drug by First Generation Solid Dispersion Method. Latin American Journal of Pharmacy. 2022;41:3.
Gurung J, Anjudikkal J, Pulikkal AK. Amphiphilic drug–additive systems in aqueous and organic solvent–water mixed media: A comprehensive account on physicochemical properties. Journal of Molecular Liquids. 2020;318:114221.
Kitanosono T, Kobayashi S. Synthetic organic “aquachemistry” that relies on neither cosolvents nor surfactants. ACS Central Science. 2021;7(5):739-47.
Abid U, Pervaiz F, Shoukat H, Rehman S, Abid S. Fabrication and characterization of novel semi-IPN hydrogels based on xanthan gum and polyvinyl pyrrolidone-co-poly (2-acrylamido-2-methyl propane sulfonic acid) for the controlled delivery of venlafaxine. Polymer-Plastics Technology and Materials. 2022;61(6):577-92.
Abid HMU, Hanif M, Mahmood K, Aziz M, Abbas G, Latif H. Wound-Healing and Antibacterial Activity of the Quercetin–4-Formyl Phenyl Boronic Acid Complex against Bacterial Pathogens of Diabetic Foot Ulcer. ACS Omega. 2022;7(28):24415-22.
Aleem A, Khan M, Abid U, Ishfaq MF, Rouf A, Jamshaid T. Microbial analysis of selected brands of whitening creams. Saudi J Med Pharm Sci. 2020;6:178-82.
Rizwan M, Abid HMU, Akhlaq M, Manzoor A, Ansari M, Rajpoot SR, et al. COMPARATIVE EFFICACY OF ALOE VERA (ALOBARBADENSIS) AND TURMERIC (CURCUMA LONGA) ON BURN WOUND HEALING IN RABBIT MODEL. Journal of Population Therapeutics and Clinical Pharmacology. 2024;31(2):526-34.
Abid HMU, Azeem M, Qaiser M, Faqeer MT, Abid S, Shakil M, et al. NAVIGATING THE VASCULAR FRONTIER: EXPLORING QUERCETIN-BASED DRUG DELIVERY STRATEGIES IN CARDIOVASCULAR THERAPY. Journal of Population Therapeutics and Clinical Pharmacology. 2024;31(1):1702-19.
Abid S, Abid HMU, Saleem M, Khurshid U, Afzal F, Usman M, et al. " Revolutionizing Sericulture: Unleashing the Potential of Ascorbic Acid for Optimal Silkworm Well-being and Maximized Silk Production.
Bhadani A, Kafle A, Ogura T, Akamatsu M, Sakai K, Sakai H, et al. Current perspective of sustainable surfactants based on renewable building blocks. Current Opinion in Colloid & Interface Science. 2020;45:124-35.
Azeem M, Hanif M, Mahmood K, Ameer N, Ramzan N, Abid U, et al. Enhanced antibacterial and antioxidant properties of chitosan-quercetin complex containing polycaprolactone microspheres for the treatment of gastroenteritis: An in-vitro and in-vivo analysis. Materials Today Communications. 2022;31:103780.
Usman Abid HM, Hanif M, Mahmood K, Abid S, Khan M, Khurshid U, et al. Exploring the Potent Combination of Quercetin–Boronic Acid, Epalrestat, and Urea Containing Nanoethosomal Keratolytic Gel for the Treatment of Diabetic Neuropathic Pain: In Vitro and In Vivo Studies. Molecular Pharmaceutics. 2023.
Ahmad M, Khan M, Asif R, Sial N, Abid U, Shamim T, et al. Expression Characteristics and Significant Diagnostic and Prognostic Values of ANLN in Human Cancers. International Journal of General Medicine. 2022:1957-72.
Hanif M, Ameer N, Mahmood MK, Shehzad A, Azeem M, Rana HL, et al. Improved anti-inflammatory effect of curcumin by designing self-emulsifying drug delivery system. Drug Development and Industrial Pharmacy. 2021;47(9):1432-8.
Mayerhöfer TG, Pahlow S, Popp J. The Bouguer‐Beer‐Lambert law: Shining light on the obscure. ChemPhysChem. 2020;21(18):2029-46.
Yang Y-Y, Niu C-G, Huang D-W, Guo H, Feng H-P, Li L, et al. Appropriate oxygen vacancies and Mo-N bond synergistically modulate charge transfer dynamics of MoO3− x/S-CN for superior photocatalytic disinfection: Unveiling synergistic effects and disinfection mechanism. Journal of Hazardous Materials. 2023;445:130481.
Xiong S, Zeng H, Deng Y, Tang R, Wang J, Li L, et al. Unveiling the synergistic effect of internal Fe single atoms and introduced Fe3C in Enteromorpha derived biochar with enhanced peroxymonosulfate activation property towards nitenpyram removal. Biochar. 2023;5(1):19.
Ngo QP, Nguyen TT, Le QTT, Lee JH, Kim NH. Unveiling the Synergistic Effect of Atomic Iridium Modulated Zirconium‐Doped Pure Phase Cobalt Phosphide for Robust Anion‐Exchange Membrane Water Electrolyzer. Advanced Energy Materials. 2023;13(44):2301841.
Sun T, Chen J, Lao X, Zhang X, Fu A, Wang W, et al. Unveiling the Synergistic Effects of Monodisperse Sea Urchin-like PdPb Alloy Nanodendrites as Stable Electrocatalysts for Ethylene Glycol and Glycerol Oxidation Reactions. Inorganic Chemistry. 2022;61(26):10220-7.
Lv X, Jiang M, Chen J, Yan D, Jia H. Unveiling the lead resistance mechanism and interface regulation strategy of Ru-based catalyst during chlorinated VOCs oxidation. Applied Catalysis B: Environmental. 2022;315:121592.