Prevalence of Hepatitis C in Liver Cirrhosis Patients HCV Prevalence in Cirrhosis Patients

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Published: Sep 18, 2024
DOI: https://doi.org/10.61919/jhrr.v4i3.1403
Keywords:
Cirrhosis Liver Hepatitis C ALT AST PCR Elisa Viral load

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Muhammad Kashif
Department of Allied Health Sciences, Fatima Memorial Hospital College of Medicine & Dentistry, Lahore, Pakistan
Fatima Zaman
Blood Transfusion Officer, Children Hospital & ICH, Faisalabad, Pakistan
Muhammad Hassan Uzman Uzman
Deputy Medical Superintendent (DMS-OPD), Children Hospital & ICH, Faisalabad, Pakistan
Tehreem Shabbir
Department of Medical Laboratory Technology, Riphah International University, Lahore, Pakistan
Nadeem Ul Hassan Khan
Department of Forensic Medicine, University of Health Sciences, Lahore, Pakistan
Sania Atta
Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan
Saleha Shiraz
Department of Allied Health Sciences, Fatima Memorial Hospital College of Medicine & Dentistry, Lahore, Pakistan
Muhammad Ali Zahid
Senior Lecturer, Department of Allied Health Sciences, Fatima Memorial Hospital College of Medicine & Dentistry, Lahore, Pakistan
Atif Munir
Department of Allied Health Sciences, Fatima Memorial Hospital College of Medicine & Dentistry, Lahore, Pakistan

Abstract

Background: Hepatitis C Virus (HCV) is a major cause of chronic liver disease, including liver cirrhosis, globally. Identifying the prevalence of HCV among cirrhotic patients can improve clinical outcomes and guide management strategies.
Objective: To determine the prevalence of HCV in patients with liver cirrhosis and assess the association between liver enzyme levels (ALT and AST) and HCV infection.
Methods: This retrospective observational study was conducted at Fatima Memorial Hospital, Lahore, from June 2023 to December 2023. Fifty liver cirrhosis patients with abnormal liver function tests were included. HCV infection was evaluated using ELISA for antibodies and PCR for RNA detection. Data analysis was performed using IBM SPSS version 25.0, with a p-value of <0.05 considered significant.
Results: Among 50 cirrhotic patients, 60% tested positive for HCV antibodies via ELISA, and 46% were confirmed positive by PCR. Mean ALT levels were significantly higher in ELISA-positive (867 U/L) and PCR-positive (1096.43 U/L) patients compared to ELISA-negative (42 U/L) and PCR-negative (59.96 U/L) patients (p < 0.001).
Conclusion: A significant prevalence of HCV was observed among liver cirrhosis patients, with elevated ALT and AST levels indicating liver damage associated with HCV infection.

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How to Cite
Kashif, M., Fatima Zaman, Uzman, M. H. U., Tehreem Shabbir, Nadeem Ul Hassan Khan, Sania Atta, Shiraz, S., Muhammad Ali Zahid, & Atif Munir. (2024). Prevalence of Hepatitis C in Liver Cirrhosis Patients: HCV Prevalence in Cirrhosis Patients. Journal of Health and Rehabilitation Research, 4(3), 1–4. https://doi.org/10.61919/jhrr.v4i3.1403
Issue
Vol. 4 No. 3 (2024): Volume 4, Issue 3 - July to September 2024
Section
Articles
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This work is licensed under a Creative Commons Attribution 4.0 International License.

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