Relation of Iron Deficiency Anemia in Pre-Menopause Women with Calcium and Vitamin D Levels at Teaching Hospital
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Abstract
Background: Iron deficiency anemia (IDA) is a common condition influenced by various factors, such as age, symptom duration, and other biochemical markers. Premenopausal women often experience premenstrual syndrome (PMS), which is frequently associated with reduced blood levels of calcium and vitamin D. Given the worldwide public health concern of osteoporosis, understanding lifetime preventive measures is crucial.
Methods: This study aimed to explore the relationship between IDA and various clinical characteristics in 161 participants. We evaluated parameters including age, symptom duration, and levels of calcium and vitamin D to identify potential associations with IDA. Data for the 161 patients were collected using a predesigned proforma, as approved by the ethics committee. The Chi-square test was employed to determine statistical significance, with a P-value threshold set at 0.05.
Results: The average age of participants was 38.6 years, with the majority (58.4%) reporting symptoms for an average duration of 58.4 months. Among them, 54% had confirmed cases of IDA. However, there was no significant age-related correlation with IDA. Notably, a strong correlation was observed between IDA and low vitamin D levels, which were present in 79.8% of the patients. Conversely, no significant relationship was found between calcium levels and IDA.
Conclusion: Current research underscores the complex interplay between IDA and various clinical factors. Low vitamin D levels appear to be strongly linked with IDA, whereas age and symptom duration are not reliable indicators of the condition. This emphasizes the importance of considering multiple factors in the diagnosis and treatment of IDA, particularly focusing on the potential role of vitamin D in its pathogenesis. Further prospective studies are needed to confirm and expand upon these findings, potentially leading to improved treatment and diagnostic strategies for patients with IDA.
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References
Pasricha S-R, Tye-Din J, Muckenthaler MU, Swinkels DW. Iron deficiency. The Lancet. 2021;397(10270):233-48.
Shihab AS, Hamdi MA, Jumaa AM, Marbut MM, Jwad SK. Dyslipidemia and other parameters in women with pregnancy induced hypertension. J Popul Ther Clin Pharmacol. 2022;29(1):e116-e21.
Ahuja M. Age of menopause and determinants of menopause age: A PAN India survey by IMS. Journal of mid-life health. 2016;7(3):126.
Salman Jasim H, Khalid Shafeeq N, Abass EAA. Vitamin D Level and its Relation with the Newly Diagnosed Diabetic Neuropathy in Women with Hypothyroidism. Arch Razi Inst. 2022;77(3):1139-45.
Al-Rawaf SA, Mousa ET, Kamal Abdulhussein F. Correlation between Serum Vitamin D and Calcium Levels in Missed Miscarriage. Arch Razi Inst. 2022;77(4):1349-53.
Kungurtseva A. Relationship between vitamin D level and postoperative complications in the practice of a plastic surgeon. Journal of Complementary Medicine Research. 2021;11(5):159-.
Keikha F, Ansari H, Khosravi M, Seraji M. The effect of educational intervention on health literacy and nutritional performance of female high school students in Zahedan. Journal of Health Literacy. 2021;6(1):41-50.
Hassani MK. Role of Vitamin D as Protective Agent against Induced Liver Damage in Male Rats. Arch Razi Inst. 2021;76(6):1815-22.
Arliny Y, Yunus F, Burhan E, Andarini S, Jusman SWA, Yunir E, et al. Diagnostic Predictors of Active Tuberculosis Infection in Diabetic Patients with Latent Tuberculosis: A Review on Cathelicidin and 1, 25‑dihydroxyvitamin D. infection (LTBI). 2021;1:2.
Samadbeik M, Saremian M, Sohrabizadeh M, Birjandi M, Garavand S. Evaluation of E-health literacy in Paramedicine and Health Nutrition students of Lorestan University of Medical Sciences. Journal of Health Literacy. 2020;5(1):12-22.
Çolak Y, Afzal S, Nordestgaard BG. 25-Hydroxyvitamin D and Risk of Osteoporotic Fractures: Mendelian Randomization Analysis in 2 Large Population-Based Cohorts. Clin Chem. 2020;66(5):676-85.
Singh M, Rajoura OP, Honnakamble RA. Anemia-related knowledge, attitude, and practices in adolescent schoolgirls of Delhi: A cross-sectional study. Int J Health Allied Sci. 2019;8(2):144-8.
Shaheena A, Manjrekar P, D'souza V, Kamath P, Rukmini M, Chandran V, et al. Does serum Vitamin D status influence high-sensitivity c-reactive protein and gensini score in established coronary artery disease individuals. Journal of Natural Science, Biology and Medicine. 2019;10(2):197-201.
Ahankari AS, Myles PR, Fogarty AW, Dixit J, Tata LJ. Prevalence of iron-deficiency anaemia and risk factors in 1010 adolescent girls from rural Maharashtra, India: a cross-sectional survey. Public Health. 2017;142:159-66.
Mengistu G, Azage M, Gutema H. Iron deficiency anemia among in-school adolescent girls in rural area of Bahir Dar City Administration, North West Ethiopia. Anemia. 2019;2019.
Kumar A. Association of Vitamin D with vascular inflammation. Journal of Natural Science, Biology and Medicine. 2019;10(2):103-.
Zareef TA, Jackson RT, Alkahtani AA. Vitamin D Intake among Premenopausal Women Living in Jeddah: Food Sources and Relationship to Demographic Factors and Bone Health. J Nutr Metab. 2018;2018:8570986.
Akbari M, Moosazadeh M, Tabrizi R, Khatibi SR, Khodadost M, Heydari ST, et al. Estimation of iron deficiency anemia in Iranian children and adolescents: a systematic review and meta-analysis. Hematology. 2017;22(4):231-9.
Tezera R, Sahile Z, Yilma D, Misganaw E, Mulu E. Prevalence of anemia among school-age children in Ethiopia: a systematic review and meta-analysis. Systematic reviews. 2018;7:1-7.
Paavonen J, Brunham RC. Bacterial Vaginosis and Desquamative Inflammatory Vaginitis. N Engl J Med. 2018;379(23):2246-54.
Mishra V, Verneker R, Gandhi K, Choudhary S, Lamba S. Iron deficiency anemia with menorrhagia: Ferric carboxymaltose a safer alternative to blood transfusion. Journal of mid-life health. 2018;9(2):92.
Kharroubi A, Saba E, Smoom R, Bader K, Darwish H. Serum 25-hydroxyvitamin D and bone turnover markers in Palestinian postmenopausal osteoporosis and normal women. Arch Osteoporos. 2017;12(1):13.
Gao C, Qiao J, Li SS, Yu WJ, He JW, Fu WZ, et al. The levels of bone turnover markers 25(OH)D and PTH and their relationship with bone mineral density in postmenopausal women in a suburban district in China. Osteoporos Int. 2017;28(1):211-8.