Frequency of Fall Risk in Patients with Diabetic Peripheral Neuropathy and its Impact on Quality of Life
Main Article Content
Abstract
Background: Diabetic Peripheral Neuropathy (DPN) is a common complication of diabetes mellitus, leading to a significant risk of falls and adversely affecting the quality of life (QOL). Understanding the frequency of fall risk and its impact on QOL among patients with DPN is essential for developing targeted interventions.
Objective: The study aimed to determine the frequency of fall risk in patients with diabetic peripheral neuropathy and assess its impact on their quality of life.
Methods: A descriptive cross-sectional study was conducted over six months at AIMS Diabetic Centre, Hayatabad Peshawar. A total of 246 patients with DPN, aged 40 years and above, were enrolled using a non-probability convenience sampling technique. Fall risk was evaluated using the Functional Reach Test (FRT), and quality of life was assessed through the Short Form-36 (SF-36) questionnaire. Data were analyzed using SPSS version 25, focusing on descriptive and inferential statistics.
Results: Among the participants, 69.5% (n=171) were identified at risk of falling. The FRT scores indicated that 13.0% (n=32) had a high fall risk, 45.93% (n=113) had a moderate fall risk, and 10.52% (n=26) had a low fall risk. Quality of life assessments revealed impairments across all domains of the SF-36, with significant variations observed between genders and DPN severity. The mean SF-36 score for physical functioning was notably lower among patients with a high fall risk.
Conclusion: The study underscores a significant association between DPN and an increased risk of falls, with a consequential negative impact on the quality of life. These findings highlight the need for integrated care strategies focusing on fall prevention and quality of life improvement for patients with diabetic peripheral neuropathy.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
Riandini T, Wee HL, Khoo EYH, Tai BC, Wang W, Koh GCH, et al. Functional status mediates the association between peripheral neuropathy and health-related quality of life in individuals with diabetes. Acta Diabetol. 2018 Feb;55(2):155–64.
Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL, et al. Diabetic neuropathy. Nat Rev Dis Prim. 2019 Dec;5(1).
Cho N, Shaw J, Karuranga S, … YH-D research and, 2018 undefined. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Elsevier. [cited 2022 Sep 19].
Witzel II, Jelinek HF, Khalaf K, Lee S, Khandoker AH, Alsafar H. Identifying common genetic risk factors of diabetic neuropathies. Front Endocrinol (Lausanne). 2015;6(MAY):1–18.
Woalder. HHS Public Access. Physiol Behav. 2017;176(1):139–48.
Vinik AI, Strotmeyer ES, Nakave AA, Patel CV. Diabetic Neuropathy in Older Adults. Clin Geriatr Med. 2008;24:407–35.
Orlando G, Balducci S, Bazzucchi I, Pugliese G, Sacchetti M. The impact of type 1 diabetes and diabetic polyneuropathy on muscle strength and fatigability. Acta Diabetol. 2017 Jun;54(6):543–50.
Kluding PM, Bareiss SK, Mueller MJ. Physical Training and Activity in People With Diabetic Peripheral Neuropathy: Paradigm Shift. Physical Stress Theory (PST) as a Framework to Support a Paradigm Shift. 2020;1–15.
J.L. E, A.M. V, H.T. C, E.L. F. Diabetic neuropathy: Mechanisms to management. Pharmacol Ther. 2008;120(1):1–34.
Yin L, Zhang D, Ren Q, Su X, Sun Z. Prevalence and risk factors of diabetic retinopathy in diabetic patients. Medicine (Baltimore). 2020;99(9):e19236.
V.K PD, Kulsum SU. The Effect of Impaired Balance and Fall Risk on Quality of Life in Patients With Diabetic Peripheral Neuropathy. Int J Physiother Res. 2019;7(5):3239–46.
Nomura T, Ishiguro T, Ohira M, Ikeda Y. Diabetic polyneuropathy is a risk factor for decline of lower extremity strength in patients with type 2 diabetes. J Diabetes Investig. 2018;9(1):186–92.
Booya F, Bandarian F, Larijani B, Pajouhi M, Nooraei M, Lotfi J. Potential risk factors for diabetic neuropathy: A case control study. BMC Neurol. 2005;5:1–5.
Tesfaye S, Chaturvedi N, Eaton SEM, Ward JD, Manes C, Ionescu-Tirgoviste C, et al. Vascular Risk Factors and Diabetic Neuropathy. N Engl J Med. 2005 Jan 27;352(4):341–50.
Venkataraman K, Tai BC, Khoo EYH, Tavintharan S, Chandran K, Hwang SW, et al. Short-term strength and balance training does not improve quality of life but improves functional status in individuals with diabetic peripheral neuropathy: a randomised controlled trial. Diabetologia. 2019 Dec;62(12):2200–10.
Zhang P, Lu J, Jing Y, Tang S, Zhu D, Bi Y. Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis. Ann Med. 2017;49(2):106–16.
Iqbal Z, Azmi S, Yadav R, Ferdousi M, Kumar M, Cuthbertson DJ, et al. Diabetic Peripheral Neuropathy: Epidemiology, Diagnosis, and Pharmacotherapy. Clin Ther. 2018 Jun;40(6):828–49.
Umanath K, Lewis JB. Update on Diabetic Nephropathy: Core Curriculum 2018. Am J Kidney Dis. 2018 Jun;71(6):884–95.
Penlioglou T, Papanas N. New Diagnostic Tools for Diabetic Polyneuropathy. J Gen Emerg Med. 2018;3(2):3–4.
Singh K. Effect of Proprioceptive Neuromuscular Facilitation (PNF) in Improving Sensorimotor Function in Patients with Diabetic Neuropathy Affecting Lower Limbs. Int J Physiother. 2016;3(3):332–6.
Nomura T, Kawae T, Kataoka H, Ikeda Y. Assessment of lower extremity muscle mass, muscle strength, and exercise therapy in elderly patients with diabetes mellitus. Environ Health Prev Med. 2018;23(1):1–7.
El-wishy A, Elsayed E. Effect of Proprioceptive Training Program on Balance in Patients with Diabetic Neuropathy: A controlled randomized study. 2012;17(2):1–8.
Yaribeygi H, Butler AE, Sahebkar A. Aerobic exercise can modulate the underlying mechanisms involved in the development of diabetic complications. J Cell Physiol. 2019;234(8):12508–15.
Billinger SA, Sisante JFV, Alqahtani AS, Pasnoor M, Kluding PM. Aerobic exercise improves measures of vascular health in diabetic peripheral neuropathy. Int J Neurosci. 2017;127(1):80–5.
Waje A, Kale J. To Study “Effectiveness of Balance Training Exercise and Pnf Exercise Versus Only Balance Training Exercise in Patients With Diabetic Peripheral Neuropathy”. Indian J Appl Res. 2020;(2):1–3.
Kluding PM, Pasnoor M, Singh R, Jernigan S, Farmer K, Rucker J, et al. The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy. J Diabetes Complications. 2012 Sep;26(5):424–9.
Ahmad I, of MH-J of the IA, 2018 undefined. Effect of progressive balance training on berg balance scale in diabetic peripheral neuropathy patients. search.ebscohost.com [Internet]. [cited 2020 Dec 15];
Riandini T, Khoo EYH, Tai BC, Tavintharan S, Phua MSLA, Chandran K, et al. Fall Risk and Balance Confidence in Patients With Diabetic Peripheral Neuropathy: An Observational Study. Front Endocrinol (Lausanne). 2020;11(October):1–5.
Short Form 36 - an overview | ScienceDirect Topics [Internet]. [cited 2020 Jan 27].
Parasoglou P, Rao S, Slade JM. Declining Skeletal Muscle Function in Diabetic Peripheral Neuropathy. Clin Ther. 2017;39(6):1085–103.
Tofthagen C, Overcash J, Kip K. Falls in persons with chemotherapy-induced peripheral neuropathy. Support Care Cancer. 2012 Mar;20(3):583–9.
Mi M, Mon T, Mnsc W, Fukai K, Htwe |, Nyunt Mnsc H, et al. Prevalence of peripheral neuropathy and its impact on activities of daily living in people with type 2 diabetes mellitus. Wiley Online Libr. 2019 Dec;21(4):445–53.
Cederlund RI, Thomsen N, Thrainsdottir S, Eriksson KF, Sundkvist G, Dahlin LB. Hand disorders, hand function, and activities of daily living in elderly men with type 2 diabetes. J Diabetes Complications. 2009;23(1):32–9.